that in humans is encoded by the CYP1A1 gene. The protein is a member of the cytochrome P450 superfamily of enzymes. CYP1A1 is involved in phase I xenobiotic...

its rapid metabolic degradation by CYP1A1. In the first analyses of the metabolism of FICZ, human recombinant CYP1A1 enzyme and S9 fractions prepared from...

Experiments with strains of mice engineered to remove (knockout) CYP1A1 and CYP1B1 reveal that CYP1A1 primarily acts to protect mammals from low doses of BaP,...

relates to the activity of cytochrome P450 subclass 1A1 (CYP1A1). Seemingly, the high activity of CYP1A1 in the intestinal mucosa prevents major amounts of...

suggests that methysticin and the related compound dihydromethysticin have CYP1A1 inducing effects which may be responsible for their toxicity. Additionally...

which are formed mainly by a number of cytochrome P450 liver enzymes (CYP1A1, 1A2, 2C8, 2C9). One of them is a dicarboxylic acid, the other two are hydroxylated...

CYP3A4 and, to a lesser degree, by CYP1A2 and the extrahepatic isoform CYP1A1 "Verapamil: Drug information. Lexicomp". UpToDate. Archived from the original...

oxidation was also demonstrated with human cytochrome P450 (CYP) enzymes, with CYP1A1 being the major enzyme involved in the oxidation of Sudan I in human tissues...

(0–20%) with negligible contributions from the less abundant enzymes CYP3A5, CYP1A1, and CYP3A4. 4-hydroxyclonidine, the main metabolite of clonidine, is also...

the induction of cytochrome P450, family 1, subfamily A, polypeptide 1 (Cyp1a1) resultant from TCDD exposure, which was determined to be directly related...

transcription of genes including CYP1A1, resulting in increased CYP1A1 protein production. This process is similar to induction of CYP1A1 by certain polychlorinated...

CYP1A1 and CYP1A2, CYP1B1 was not identified and sequenced until 1994. Nucleic and amino acid analysis showed approximately 40% identity with CYP1A1....

correlated with elevated levels of expression of selected cytochrome P450s (CYP1A1/1A2, 2B1/2B2, 2E1) in PC12 cells exposed to monocrotophos (10−5 M). NIOSH...

variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, among others. The 308 G/A single nucleotide polymorphism variation...

species that may independently damage DNA. Enzymes in the cytochrome family (CYP1A1, CYP1A2, CYP1B1) metabolize PAHs to diol epoxides. PAH exposure can increase...

Schunck WH, Roots I (2001). "Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect...

Estrogens are metabolized via hydroxylation by cytochrome P450 enzymes such as CYP1A1 and CYP3A4 and via conjugation by estrogen sulfotransferases (sulfation)...

Enzyme Inhibitors Inducers CYP1A1 Certain foods (e.g., cumin, turmeric) Certain herbs/herbal teas (e.g., peppermint, German chamomile, dandelion, Kava)...

a compound used as the substrate in the measurement of cytochrome P450 (CYP1A1) induction using the ethoxyresorufin-O-deethylase (EROD) assay system in...

frequency of CYP alleles involved in clozapine metabolism such as UGT1A and CYP1A1/1A2. This found faster average clozapine metabolism in people of sub-Saharan...

primarily metabolized by the liver enzyme CYP1A2 and to a lesser extent by CYP1A1, CYP2C19, and CYP1B1. For both research and clinical purposes, melatonin...

products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. Similar to delta-9-THC, a majority of CBD is...

stimulation of NF-κB. In the intestine, TLR2 regulates the expression of CYP1A1, which is a key enzyme in detoxication of carcinogenic polycyclic aromatic...

"Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol". Toxicol Lett. 208 (1): 51–61. doi:10.1016/j.toxlet...

CYP3A4 and, to a lesser degree, by CYP1A2 and the extrahepatic isoform CYP1A1 "Cyclobenzaprine". DrugBank. Archived from the original on 27 October 2018...

Pharmacokinetic data Bioavailability 94% Protein binding 95% Metabolism CYP1A1, CYP3A4, CYP2C8, CYP2J2 Metabolites N-desmethylriociguat (active), glucuronide...

Ciolino, H. P.; Yeh, G. C. (1999). "The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor". British...

omega oxidation reaction. The human cytochrome P450 (CYP) epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize...

Coenraads PJ, Dong L, Zhao LJ, Ma SW, et al. (April 2008). "Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with...

Saint-John's wort, a common herbal remedy induces CYP3A4, but also inhibits CYP1A1, CYP1B1. Tobacco smoking induces CYP1A2 (example CYP1A2 substrates are clozapine...