CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a...
3 KB (386 words) - 14:20, 24 January 2024
absorption. Zonisamide is metabolized mostly by the CYP3A4 isoenzyme, but also CYP3A7 and CYP3A5, to 2-(sulphamoylacetyl)-phenol via reductive cleavage of the...
24 KB (2,038 words) - 06:46, 24 May 2024
dehydroepiandrosterone sulfate (DHEA-S).[citation needed] DHEA-S is hydroxylated by high CYP3A7 expression and activity into 16α-hydroxy-DHEA-S (16α-OH-DHEA-S) in the fetal...
22 KB (2,085 words) - 12:46, 21 October 2024
cholestasis. Fetuses do not express CYP3A4 in their liver tissue, but rather CYP3A7 (EC 1.14.14.1), which acts on a similar range of substrates. CYP3A4 increases...
80 KB (7,794 words) - 00:31, 3 December 2024
effective metabolites by various CYP450 enzymes including CYP3A4, CYP3A5, CYP3A7, and CYP2C9. The majority of alprazolam metabolism is mediated by hydroxylation...
25 KB (2,877 words) - 22:38, 8 December 2023
other lipids. The CYP3A cluster consists of four genes: CYP3A4, CYP3A5, CYP3A7, and CYP3A43. The region also contains four pseudogenes: CYP3A51P, CYP3A52P...
9 KB (1,005 words) - 05:00, 15 December 2023
migrates as a 52.0-kD protein. The human CYP3A subfamily, CYP3A4, CYP3A5, CYP3A7 and CYP3A43, is one of the most versatile of the biotransformation systems...
32 KB (1,959 words) - 05:16, 2 May 2024
including isoenzymes CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7. It increases metabolism of many drugs and as a consequence, can make them...
47 KB (4,718 words) - 05:12, 30 October 2024
HGNC:20243 Q8TAV3 3889 CYP3A4 HGNC:2637 P08684 3890 CYP3A5 HGNC:2638 P20815 3891 CYP3A7 HGNC:2640 P24462 3892 CYP3A43 HGNC:17450 Q9HB55 3893 CYP4A11 HGNC:2642 Q02928...
277 KB (17 words) - 18:34, 6 October 2024
testosterone) metabolism 1 subfamily, 4 genes, 4 pseudogenes CYP3A4, CYP3A5, CYP3A7, CYP3A43 CYP3A51P, CYP3A52P, CYP3A54P, CYP3A137P CYP4 arachidonic acid or...
42 KB (4,497 words) - 18:55, 1 October 2024
cytochrome P450 enzymes CYP3A4 and CYP3A5. It may also be metabolized by CYP3A7 in fetal liver and the placenta. Unlike progesterone, hydroxyprogesterone...
121 KB (12,026 words) - 08:48, 2 November 2024