Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the...
12 KB (1,350 words) - 18:12, 22 April 2024
Cereblon E3 ligase modulators, also known as immunomodulatory imide drugs (IMiDs), are a class of immunomodulatory drugs (drugs that adjust immune responses)...
49 KB (5,487 words) - 11:41, 24 January 2024
Lenalidomide (category Cereblon E3 ligase modulators)
belongs to a class of drugs known as immunomodulatory imide drugs (IMiDs) or Cereblon E3 ligase modulators, which includes thalidomide and its analogs. In lymphocytes...
29 KB (2,483 words) - 05:43, 9 August 2024
Thalidomide (category Cereblon E3 ligase modulators)
in both their anti-cancer and teratogenic effects is now known to be as cereblon E3 ligase modulators. Thalidomide also binds to and acts as an antagonist...
77 KB (7,479 words) - 18:04, 16 August 2024
Mezigdomide (category Cereblon E3 ligase modulators)
Mezigdomide is a cereblon E3 ligase modulator developed by Bristol Myers Squibb to treat multiple myeloma. Richardson, Paul G.; Trudel, Suzanne; Quach...
7 KB (406 words) - 00:39, 18 December 2023
Pomalidomide (category Cereblon E3 ligase modulators)
and anti-myeloma activities. Like thalidomide, pomalidomide works as a cereblon E3 ligase modulator. Pomalidomide can cause harm to unborn babies when...
18 KB (1,273 words) - 10:05, 17 June 2024
Room (Press release). 2022-01-13. Retrieved 2023-05-23. "SP-3164, a Novel Cereblon-Binding Protein Degrader, Shows Activity in Preclinical Lymphoma Models"...
15 KB (1,369 words) - 20:29, 22 July 2024
Iberdomide (category Cereblon E3 ligase modulators)
Iberdomide is an experimental thalidomide analog that works as an cereblon E3 ligase modulator; it has a higher binding affinity than lenalidomide or pomalidomide...
11 KB (746 words) - 15:52, 3 June 2024
AP, Coleman K, Crews CM (June 2015). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–63. doi:10...
15 KB (1,560 words) - 07:10, 2 August 2024
2010-03-21. As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide "Thalidomide: The Fifty Year Fight...
40 KB (4,033 words) - 02:17, 4 August 2024
Avadomide (category Cereblon E3 ligase modulators)
Avadomide is an experimental cereblon E3 ligase modulator, or thalidomide analog studied to see if it is effective against cancer. Nishi, Hidemi; Gotoh...
7 KB (428 words) - 04:34, 31 January 2024
alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) CRBN: Cereblon protein DCLK3: Doublecortin like kinase 3 DLEC1: encoding protein Deleted...
34 KB (1,982 words) - 21:02, 24 August 2024
pathogenesis of certain viruses including HIV. A component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide...
36 KB (4,418 words) - 03:28, 3 December 2023
CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide. Human CUL4B is 913...
23 KB (2,948 words) - 23:56, 9 September 2023
CTBP1, HDAC1, HDAC7A, Histone deacetylase 5, IKZF2, IKZF3, IKZF4, SIN3A, Cereblon SIN3B. GATA2 GRCh38: Ensembl release 89: ENSG00000185811 – Ensembl, May...
22 KB (2,410 words) - 07:37, 25 July 2024