Conformational proofreading or conformational selection is a general mechanism of molecular recognition systems, suggested by Yonatan Savir and Tsvi Tlusty...

which does not require expenditure of free energy is that of conformational proofreading. The incorrect product may also be formed but hydrolyzed at a...

Savir Y, Tlusty T (May 2007). Scalas E (ed.). "Conformational proofreading: the impact of conformational changes on the specificity of molecular recognition"...

OCLC 887605755. Savir Y, Tlusty T (May 2007). "Conformational proofreading: the impact of conformational changes on the specificity of molecular recognition"...

models for how RecA finds complementary DNA. In one model, termed conformational proofreading, the DNA duplex is stretched, which enhances sequence complementarity...

the presence of competition and noise via the conformational proofreading mechanism. These conformational changes also bring catalytic residues in the...

the appropriate tRNA, the ribosome utilizes large conformational changes (conformational proofreading). The small ribosomal subunit, typically bound to...

ability to discriminate between several competing targets via the conformational proofreading mechanism. Dynamic molecular recognition is also being studied...

duplex, which enhances homology recognition (a mechanism termed conformational proofreading). Upon finding such a sequence, the single-stranded nucleoprotein...

the appropriate tRNA, the ribosome utilizes large conformational changes (conformational proofreading). Now the P site contains the beginning of the peptide...

The most accepted view is that the TCR engages in kinetic proofreading. The kinetic proofreading model proposes that a signal is not directly produced upon...

and the enzyme complex undergoes conformational changes of subdomains and amino acid residues. These conformational changes allow the rate of repair synthesis...

proteins, like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and bacterial translocation) and termination: Rifamycin...

incorporated nucleotides in a 3' to 5' direction in a process known as proofreading. A fifth domain contains another exonuclease active site that removes...

Andersen, GR (May 2003). "Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase". Nature Structural...

with MHC-I. This process is known as peptide proofreading or editing. Peptides selected through proofreading improve MHC-I stability; tapasin also contributes...

allows the incorrect base pair to be excised (this activity is known as proofreading). Following base excision, the polymerase can re-insert the correct base...

Traditional view including strand-exchange followed by branch-migration (proofreading). The mechanism occurs in the framework of a synaptic complex (1) including...

original DNA strand as well as a newly synthesized strand. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication...

across its N3-C6 axis. The C-C bond gives it more rotational freedom and conformational flexibility. In addition, pseudouridine has an extra hydrogen bond donor...

sequence of bases in the template strand. Many DNA polymerases have a proofreading activity. Here, the polymerase recognizes the occasional mistakes in...

functions. To ensure that the genome successfully passes the information on, proofreading mechanisms such as exonucleases and mismatch repair systems are incorporated...

being sealed by DNA ligase) and provides a signal that directs mismatch proofreading systems to the appropriate strand. This implies that these nicks must...

elongation factors such as TFIIS. This pausing is also sometimes used for proofreading; here the polymerase backs up, erases some of the RNA it has already...

genetic plasticity, but SARS-CoV-2's viral evolution is slowed by the RNA proofreading capability of its replication machinery. For comparison, the viral mutation...

Correct NTP binding causes the RdRp to undergo a conformational change. Active site closure – the conformational change, initiated by the correct NTP binding...

the correction of mismatched base pairs that have been missed by the proofreading element (Klenow fragment) of the DNA polymerase complex. The post-replicative...

worked on error correction in transcription and translation (kinetic proofreading), and associative memory models (Hopfield net) Arthur L. Horwich — chaperonins...

fidelity to the replication process. The exoribonuclease provides a proofreading function to the complex which the RNA-dependent RNA polymerase lacks...

Whitford PC (October 2016). "How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome". Nature Communications. 7: 13314. Bibcode:2016NatCo...