Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway...

IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining...

as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC50 curve...

inversely related to its half maximal effective concentration (EC50) value. The EC50 can be measured for a given agonist by determining the concentration...

potential channels TRPA1 (EC50 = 700 nM), TRPV1 (EC50 = 1,300 nM), TRPV2 (EC50 = 1,720 nM), TRPV3 (EC50 = 1,000 nM), and TRPV4 (EC50 = 5,100 nM) (efficacy...

EK45 Westover March 9, 2000 Socorro LINEAR  · 4.0 km MPC · JPL 17237 2000 EC50 — March 7, 2000 Višnjan Observatory K. Korlević  · 2.9 km MPC · JPL 17238...

on binding affinity. Potency of drug is the measure of its effectiveness, EC50 is the drug concentration of a drug that produces an efficacy of 50% and...

as a strong non-competitive selective NMDA receptor antagonist, with an EC50 of 20 μM; which might promote sedation in addition with the strong antihistaminergic...

estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting...

toxicology, there are some other safety factors including LD50, LC50 and EC50. Threshold dose is a dose of drug barely adequate to produce a biological...

compared to D9-THC (1.6x). 9R-HHC has an EC50 of 3.4nM ± 1.5nM at CB1 and 6.2nM ± 2.1nM at CB2 while 9S-HHC has an EC50 of 57nM ± 19nM at CB1 and 55nM ± 10nM...

among individual plants and populations. Notes: In brackets is the IC50/EC50 value depending on whether it is an inhibitory or inductive action being...

= 208 nM) in vitro, whereas it was inactive for serotonin (EC50 > 10,000 nM) and the EC50 for norepinephrine was not assessed but the drug induced 96%...

much lower potency in stimulating the 5-HT2A receptor β-arrestin pathway (EC50 = 3,485 ± 234 nM; Emax = 108 ± 16%). In contrast to the 5-HT2A receptor,...

the CB1 receptors with an EC50 of 44.4nM for 9R-HHCP and 134nM for 9S-HHCP. Compared to Hexahydrocannabinol (HHC) with an EC50 of 101nM for 9R-HHC and 1...

Protective index Median toxic dose (TD50) Lowest published lethal dose (LDLo) EC50 (half maximal effective concentration) IC50 (half maximal inhibitory concentration)...

activity of solriamfetol at human, mouse, and rat TAAR1 receptors. hTAAR1 EC50 values (10–16 μM) were within the clinically observed therapeutic solriamfetol...

releasing agent >10,000 (EC50) NETTooltip Norepinephrine transporter 13,000 NRATooltip Norepinephrine releasing agent >10,000 (EC50) σ1 >10,000 σ2 >10,000...

inserting a letter after the digit and before the space: EC1–EC4 (but not EC50), SW1, W1, WC1, WC2 and parts of E1 (E1W), N1 (N1C and N1P), NW1 (NW1W) and...

inhibition at CB1 it displays a similar efficacy to that of Δ9-THC (EC50 = 11 nM vs. EC50 = 5.2 nM, respectively), but a lower maximum response (Emax = 28%...

(Ki = 0.9 nM; EC50 = 13.0 nM; IATooltip intrinsic activity = 89%) and κ-opioid receptor (Ki = 2.6 nM; EC50 = 17 nM; IA = 67%). The EC50 values of 0.5–5...

interactions with the other serotonin receptors. Whereas vortioxetine has IC50 or EC50 values of 5.4 nM for the SERT and 12 nM for the 5-HT3 receptor, its values...

act as a partial agonist of the κ-opioid receptor at high concentrations (EC50 = 7.2 μM). Antagonism of the α2-adrenergic receptors, which function largely...

eliciting 50% of its maximal effect (half maximal effective concentration = EC50) at the human 5-HT2A receptor in vitro are in the 0.118–0.983 μmol/L range...

HCN1Tooltip Hyperpolarization-activated cyclic nucleotide-gated channel 1 8–16 EC50 Inhibitor Mouse TRPV1 1-100 Ki Agonist Rat The smaller the value, the stronger...

4 μM). In contrast, both CBP and nCBP are functional agonists on 5HT1a (EC50= 5.3 and 3.2 μM). [...] CPB and nCBP are potent antagonists of 5HT2a, 5HT2b...

estrogen receptors with Ki values of 1.1 μM and 0.5 μM, respectively, and EC50 values of >1 μM and 200 nM, respectively. Though it was found to be a partial...

dopamine with EC50 values of 50.4 ± 5.4 nM and 131 ± 11 nM, respectively. It has negligible efficacy as a releaser of serotonin, with an EC50 value of only...

a quick description of the binding of a substance, in the same way that EC50 and IC50 describe the biological activities of substances. Experimentally...

is a non-selective opioid receptor ligand, so this is not MOR-specific.) EC50 is for hMOR1 GTPyS binding. Cmax and AUC levels are for 20 mg CR oxycodone...