genes for endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3) are located on chromosomes 6, 1, and 20, respectively. Endothelin functions...
17 KB (1,655 words) - 20:05, 8 December 2023
Endothelin 2 (ET-2) is a protein encoded by the EDN2 gene in humans. It was first discovered in 1988 by Yanagisawa and team and belongs to a family of...
20 KB (2,419 words) - 08:00, 21 August 2023
is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin. Preproendothelin is precursor of the peptide...
3 KB (341 words) - 16:16, 30 May 2024
Aprocitentan (category Endothelin receptor antagonists)
taken by mouth. Aprocitentan is a dual endothelin-1 antagonist that targets both endothelin A and endothelin B receptors. Aprocitentan was approved for...
10 KB (631 words) - 19:16, 6 August 2024
Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G protein-coupled receptor...
15 KB (1,733 words) - 19:12, 27 March 2024
Endothelin-3 is a protein that in humans is encoded by the EDN3 gene. The protein encoded by this gene is a member of the endothelin family. Endothelins...
8 KB (1,004 words) - 23:15, 15 December 2023
There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation...
6 KB (630 words) - 00:27, 9 March 2024
Duplication of endothelin 3 Is Closely Correlated with the Hyperpigmentation of the Internal Organs (Fibromelanosis) in Silky Chickens". Genetics. 190 (2): 627–638...
6 KB (595 words) - 23:23, 24 June 2024
Macitentan (category Endothelin receptor antagonists)
Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist developed by Actelion and approved for the treatment of pulmonary arterial...
11 KB (1,012 words) - 03:53, 6 August 2024
Biomarkers of diabetes (section Endothelin-1(ET-1))
therapeutic targets for patients with prediabetes or Type 2 diabetes mellitus. Oxytocin (OXT) Omentin Endothelin-1 Nesfatin-1 Irisin Betatrophin Hepatocyte growth...
19 KB (2,713 words) - 19:08, 3 April 2024
Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown to interact with HDAC7A...
10 KB (1,181 words) - 05:28, 23 December 2023
Bosentan (category Endothelin receptor antagonists)
Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery...
13 KB (1,113 words) - 16:17, 2 May 2024
Ambrisentan (category Endothelin receptor antagonists)
the treatment of pulmonary hypertension. It is an endothelin receptor antagonist. The peptide endothelin constricts muscles in blood vessels, increasing...
10 KB (663 words) - 05:22, 1 July 2024
Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides. GRCh38:...
8 KB (1,025 words) - 23:51, 3 January 2024
alpha 2 DES: Desmin protein DIS3L2: DIS3 mitotic control homolog-like 2 ECEL1: Endothelin converting enzyme like 1 EPC2: Enhancer of polycomb homolog 2 EPB41L5:...
40 KB (2,534 words) - 05:56, 28 July 2024
hormones; angiotensin II, endothelin-1 and the catecholamines (e.g. noradrenaline).[citation needed] Angiotensin-II and endothelin-1 are hormones that bind...
15 KB (1,696 words) - 06:09, 15 July 2024
decrease collagen degradation and increase extracellular matrix production. Endothelin signalling is implicated in the pathophysiology of fibrosis. Vitamin D...
38 KB (3,291 words) - 01:18, 9 May 2024
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline)...
33 KB (3,380 words) - 19:17, 10 July 2024
Sovateltide (category Endothelin receptor agonists)
the brand name Tyvalzi) is a synthetic analog of endothelin-1 that works as a selective endothelin-B receptor agonist. In May 2023, it was approved in...
6 KB (299 words) - 12:54, 29 May 2024
Pulmonary hypertension (section Endothelin)
activity) decreases. Endothelin-1 is a peptide (comprising 21 amino acids) that is produced in endothelial cells. It acts on the endothelin receptors ETA and...
89 KB (8,903 words) - 13:59, 29 July 2024
Urocortin Antagonists: Astressin-B See here instead. Agonists: Endothelin 1 Endothelin 2 Endothelin 3 IRL-1620 Sarafotoxin Antagonists: A-192621 Ambrisentan...
14 KB (825 words) - 20:42, 9 February 2024
BQ-788 is a selective ETB antagonist. Endothelin Okada, M; Nishikibe, M (Winter 2002). "BQ-788, a selective endothelin ET(B) receptor antagonist". Cardiovascular...
2 KB (44 words) - 05:47, 29 November 2023
inhibitor) Azabon Apricoxib (COX-2 inhibitor) Celecoxib (COX-2 inhibitor) Parecoxib (COX-2 inhibitor) Bosentan (endothelin receptor antagonist) Dofetilide...
4 KB (260 words) - 08:48, 25 November 2023
Sitaxentan (category Endothelin receptor antagonists)
of endothelin (ET) on the endothelin-A (ETA) receptor selectively (by a factor of 6000 compared with the ETB). It is a sulfonamide class endothelin receptor...
8 KB (711 words) - 22:23, 21 March 2024
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. It consists...
25 KB (2,231 words) - 23:55, 13 July 2024
Alpha-2 blockers (or α2 blockers) are a subset of the alpha blocker class of drugs and are antagonists to the α2 adrenergic receptor. They are mainly...
3 KB (315 words) - 21:37, 9 March 2024
vasoconstriction, including the release of vasoconstrictor substances such as endothelin and angiotensin II, both of which play crucial roles in the modulation...
19 KB (1,648 words) - 12:50, 25 June 2024
the treatment of primary immunoglobulin A nephropathy. Sparsentan is an endothelin and angiotensin II receptor antagonist. It is taken by mouth. It was approved...
7 KB (339 words) - 20:40, 1 July 2024
Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11) is...
24 KB (2,715 words) - 22:33, 27 March 2024
The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It...
36 KB (3,880 words) - 22:38, 17 June 2024