Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer. It...
50 KB (4,674 words) - 20:52, 20 August 2024
hepatic impairment is unknown. Two 2020 meta-analyses reported that enzalutamide and apalutamide seemed to be more effective than darolutamide in improving...
42 KB (4,162 words) - 00:12, 15 September 2024
metastatic castration-resistant prostate cancer (mCRPC), which the NSAA enzalutamide and the androgen synthesis inhibitor abiraterone acetate are used to...
36 KB (3,026 words) - 22:35, 16 August 2024
medications in clinical practice. Compared to the second-generation NSAAs, enzalutamide and apalutamide, bicalutamide has inferior potency and efficacy but similar...
85 KB (8,727 words) - 01:24, 2 September 2024
N-Desmethylenzalutamide (redirect from N-desmethyl-enzalutamide)
similar activity to that of enzalutamide and, with enzalutamide therapy, circulates at similar concentrations to those of enzalutamide at steady state. N-Desmethylenzalutamide...
4 KB (232 words) - 04:23, 10 July 2024
structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide, all of which are NSAAs similarly. RU-58841 can be synthesized either...
6 KB (533 words) - 18:51, 25 October 2023
2024, the European Commission approved talazoparib in combination with enzalutamide for the treatment of metastatic castration-resistant prostate cancer...
16 KB (1,230 words) - 04:49, 15 September 2024
distribution compared to the structurally related nonsteroidal antiandrogen enzalutamide. The drug was developed by Jiangsu Hengrui Medicine. Other structural...
4 KB (181 words) - 20:06, 30 November 2023
visual disturbances, and alcohol intolerance with nilutamide. Unlike enzalutamide, bicalutamide is not associated with seizures or related central side...
217 KB (21,643 words) - 16:21, 15 September 2024
current antiandrogens that are used in the treatment of prostate cancer. Enzalutamide and related second-generation NSAAs like RD-162 and apalutamide were...
5 KB (400 words) - 10:45, 3 November 2023
prostate cancer. Structurally distinct from enzalutamide, apalutamide, and other NSAAs. Relative to enzalutamide and apalutamide, shows greater efficacy as...
17 KB (1,576 words) - 15:57, 24 February 2024
diarylthiohydantoin derivative. It is closely related to enzalutamide and apalutamide. Both RD-162 and enzalutamide show 5- to 8-fold higher affinity for the AR than...
5 KB (323 words) - 17:31, 1 September 2022
androgen blockade (also known as complete or maximal androgen blockade). Enzalutamide, apalutamide, and abiraterone acetate are specifically approved for use...
159 KB (15,079 words) - 15:42, 24 September 2024
Hung. Medivation, in collaboration with Astellas, was in development of enzalutamide for multiple stages of prostate cancer and for breast cancer. On August...
11 KB (964 words) - 03:02, 1 August 2024
antagonist of the AR reportedly comparable to the potent antagonist enzalutamide. However, the initial 5α-reduced metabolite of D4A, 3-keto-5α-abiraterone...
49 KB (4,213 words) - 01:54, 2 September 2024
Nicardipine Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol)...
37 KB (3,825 words) - 04:22, 8 September 2024
affinity and more potent inhibition of the AR relative to the other NSAAs enzalutamide and apalutamide, although they also possess much shorter and comparatively...
6 KB (385 words) - 22:13, 3 February 2024
disinhibition of the HPG axis): Antiandrogens (e.g., flutamide, bicalutamide, enzalutamide) Antiestrogens/SERMsTooltip Selective estrogen receptor modulators (e...
11 KB (1,114 words) - 12:56, 5 August 2024
disinhibition of the HPG axis): Antiandrogens (e.g., flutamide, bicalutamide, enzalutamide) Antiestrogens/SERMsTooltip Selective estrogen receptor modulators (e...
49 KB (5,382 words) - 04:44, 2 September 2024
Theravance. Xospata (gilteritinib) – AXL receptor tyrosine kinase Xtandi (enzalutamide) – Prostate cancer – marketed with Pfizer. The US Food and Drug Administration...
27 KB (2,460 words) - 00:25, 13 September 2024
Bicalutamide Flutamide Nilutamide Second-generation Apalutamide Darolutamide Enzalutamide Proxalutamide Others/non-generational Cimetidine Topilutamide Note that...
5 KB (254 words) - 18:23, 18 September 2023
Nicardipine Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol)...
51 KB (5,567 words) - 00:03, 9 September 2024
Pembrolizumab is an alternative, including quality-assured biosimilars Enzalutamide is an alternative Alternatives are 4th level ATC chemical subgroup (L02BG...
67 KB (4,835 words) - 05:59, 17 August 2024
Spironolactone Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil)...
29 KB (3,167 words) - 17:10, 11 September 2024
Spironolactone Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil)...
35 KB (3,490 words) - 02:12, 11 September 2024
Spironolactone Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil)...
9 KB (376 words) - 17:45, 11 November 2023
antiandrogens are cyproterone acetate, flutamide, nilutamide, bicalutamide, and enzalutamide which are all administered in oral pill form. New antiandrogens that...
18 KB (2,100 words) - 08:59, 23 July 2024
disinhibition of the HPG axis): Antiandrogens (e.g., flutamide, bicalutamide, enzalutamide) Antiestrogens/SERMsTooltip Selective estrogen receptor modulators (e...
34 KB (3,448 words) - 00:43, 12 August 2024
Nicardipine Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol)...
54 KB (5,403 words) - 00:00, 16 September 2024
more efficacious as an antiandrogen than other AR antagonists such as enzalutamide and spironolactone in scalp dermal papilla cells and sebocytes in vitro...
19 KB (1,617 words) - 15:13, 27 June 2024