Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have...

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which...

Galectin-9 was first isolated from mouse embryonic kidney in 1997 as a 36 kDa beta-galactoside lectin protein. Human galectin-9 is encoded by the LGALS9...

Belapectin (also known as GR-MD-02) is a galectin-3 inhibitor developed by Galectin Therapeutics that is in clinical trials for the treatment of non-alcoholic...

Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. LGALS1 contains four exons. The galectin-1 protein is 135 amino acids in length and...

July 1, 2013. In 2021, Carson joined Galectin Therapeutics to assist with development of the company's galectin-3 inhibitor, belapectin, as a treatment...

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene. The galectins are a family of beta-galactoside-binding proteins...

fibrosis, cancer and inflammation. The company was founded in 2011 by leading galectin scientists and biotech executives from Sweden, United Kingdom, and Denmark...

Carpi, Federico; Mechanick, Jeffrey I.; Bartolazzi, Armando (2010). "Galectin-3 detection on large-needle aspiration biopsy improves preoperative selection...

involved in response to lysosomal damage, often directed by galectins such as galectin-3 and galectin-8. One of the mechanisms of programmed cell death (PCD)...

Selvigaltin (GB1211) is the first small-molecule, orally delivered galectin-3 inhibitor to be discovered. It is developed by Galecto Biotech, which is...

evidence for inhibiting Galectin-3 as a therapeutic target to reduce MDSCs. In a Phase 1b clinical trial of GR-MD-02 developed by Galectin Therapeutics, investigators...

of P. pulmonarius may slow the proliferation of cancer cells with high galectin-3 levels, while at the same time downregulate tumour cell adherence – which...

MH, Kimura T, et al. (October 2016). "TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis"...

lysophagy that removes damaged lysosomes. At this stage another galectin, galectin-3, interacts with TRIM16 to guide selective autophagy of damaged lysosomes...

chemically induced colitis and augments inflammatory responses through galectin-3". The Journal of Infectious Diseases. 197 (7): 972–980. doi:10.1086/528990...

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating...

Galectin-4 is a protein that in humans is encoded by the LGALS4 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating...

(3): 753–78, vii. doi:10.1016/j.ecl.2007.04.004. PMID 17673127. Papotti M, Rodriguez J, De Pompa R, Bartolazzi A, Rosai J (April 2005). "Galectin-3 and...

biomarkers such as BNP, NT-proBNP, highly sensitive troponin, GDF-15, and galectin-3. One study indicated that discrimination is independent of age, body mass...

6 (3): 237–266. doi:10.1517/13543784.6.3.237. PMID 15989626. Gordon-Alonso M, Bruger AM, van der Bruggen P (August 2018). "Extracellular galectins as...

ARSB leads to increase in free galectin-3, which attaches more strongly to less sulfated chondroitin 4-sulfate. Galectin-3 then acts on transcription factors...

Galectin-8 is a protein of the galectin family that in humans is encoded by the LGALS8 gene. This gene encodes a member of the galectin family. Galectins...

reducing β-catenin nuclear accumulation is via the inhibition of galectin-3. The galectin-3 inhibitor GR-MD-02 is currently undergoing clinical trials in...

TB006 is a humanized monoclonal antibody targeting galectin-3, which is suspected to be a factor in the formation of amyloid plaques. Cummings, Jeffrey...

water-soluble synovial fluid protein. In synovial fluid it interacts with Galectin-3 that improves its lubricating property. Lubricin's unglycosylated regions...

Chemically Induced Colitis and Augments Inflammatory Responses through Galectin-3". The Journal of Infectious Diseases. 197 (7): 972–980. doi:10.1086/528990...

Grabski S, Wang JL, Patterson RJ (September 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic...

malignant follicular thyroid nodules. In conjunction with cyclin A and galectin-3, HK3 could be used as diagnostic biomarker to screen for malignancy in...

functional roles of galectins in cellular response to membrane damage are rapidly expanding and Deretic's group has recently shown that Galectin-3 recruits ESCRTs...