Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have...
25 KB (2,839 words) - 08:50, 18 May 2024
Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which...
34 KB (3,864 words) - 01:49, 22 June 2024
Galectin-9 was first isolated from mouse embryonic kidney in 1997 as a 36 kDa beta-galactoside lectin protein. Human galectin-9 is encoded by the LGALS9...
18 KB (2,173 words) - 06:45, 14 August 2024
Belapectin (also known as GR-MD-02) is a galectin-3 inhibitor developed by Galectin Therapeutics that is in clinical trials for the treatment of non-alcoholic...
4 KB (164 words) - 16:26, 17 February 2024
Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. LGALS1 contains four exons. The galectin-1 protein is 135 amino acids in length and...
8 KB (922 words) - 18:36, 20 November 2023
July 1, 2013. In 2021, Carson joined Galectin Therapeutics to assist with development of the company's galectin-3 inhibitor, belapectin, as a treatment...
151 KB (14,464 words) - 21:18, 18 August 2024
Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene. The galectins are a family of beta-galactoside-binding proteins...
9 KB (1,111 words) - 20:42, 13 October 2022
fibrosis, cancer and inflammation. The company was founded in 2011 by leading galectin scientists and biotech executives from Sweden, United Kingdom, and Denmark...
2 KB (294 words) - 19:18, 4 December 2023
Carpi, Federico; Mechanick, Jeffrey I.; Bartolazzi, Armando (2010). "Galectin-3 detection on large-needle aspiration biopsy improves preoperative selection...
12 KB (753 words) - 21:29, 5 July 2024
involved in response to lysosomal damage, often directed by galectins such as galectin-3 and galectin-8. One of the mechanisms of programmed cell death (PCD)...
77 KB (9,110 words) - 16:54, 19 July 2024
Selvigaltin (GB1211) is the first small-molecule, orally delivered galectin-3 inhibitor to be discovered. It is developed by Galecto Biotech, which is...
5 KB (264 words) - 08:29, 23 January 2024
evidence for inhibiting Galectin-3 as a therapeutic target to reduce MDSCs. In a Phase 1b clinical trial of GR-MD-02 developed by Galectin Therapeutics, investigators...
22 KB (2,634 words) - 05:02, 29 April 2024
of P. pulmonarius may slow the proliferation of cancer cells with high galectin-3 levels, while at the same time downregulate tumour cell adherence – which...
14 KB (1,535 words) - 14:47, 10 January 2024
MH, Kimura T, et al. (October 2016). "TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis"...
65 KB (7,147 words) - 05:41, 24 June 2024
lysophagy that removes damaged lysosomes. At this stage another galectin, galectin-3, interacts with TRIM16 to guide selective autophagy of damaged lysosomes...
119 KB (12,654 words) - 00:05, 31 July 2024
chemically induced colitis and augments inflammatory responses through galectin-3". The Journal of Infectious Diseases. 197 (7): 972–980. doi:10.1086/528990...
89 KB (9,969 words) - 15:13, 14 June 2024
Galectin-7 is a protein that in humans is encoded by the LGALS7 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating...
5 KB (699 words) - 05:53, 3 January 2024
Galectin-4 is a protein that in humans is encoded by the LGALS4 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating...
12 KB (1,609 words) - 14:15, 29 September 2022
(3): 753–78, vii. doi:10.1016/j.ecl.2007.04.004. PMID 17673127. Papotti M, Rodriguez J, De Pompa R, Bartolazzi A, Rosai J (April 2005). "Galectin-3 and...
35 KB (3,945 words) - 16:22, 29 December 2023
biomarkers such as BNP, NT-proBNP, highly sensitive troponin, GDF-15, and galectin-3. One study indicated that discrimination is independent of age, body mass...
10 KB (1,155 words) - 01:28, 24 August 2023
6 (3): 237–266. doi:10.1517/13543784.6.3.237. PMID 15989626. Gordon-Alonso M, Bruger AM, van der Bruggen P (August 2018). "Extracellular galectins as...
63 KB (7,473 words) - 02:17, 23 July 2024
ARSB leads to increase in free galectin-3, which attaches more strongly to less sulfated chondroitin 4-sulfate. Galectin-3 then acts on transcription factors...
20 KB (1,828 words) - 18:29, 9 June 2024
Galectin-8 is a protein of the galectin family that in humans is encoded by the LGALS8 gene. This gene encodes a member of the galectin family. Galectins...
10 KB (1,213 words) - 02:35, 16 July 2024
Catenin beta-1 (category Genes on human chromosome 3)
reducing β-catenin nuclear accumulation is via the inhibition of galectin-3. The galectin-3 inhibitor GR-MD-02 is currently undergoing clinical trials in...
107 KB (12,362 words) - 22:48, 10 July 2024
TB006 is a humanized monoclonal antibody targeting galectin-3, which is suspected to be a factor in the formation of amyloid plaques. Cummings, Jeffrey...
1 KB (142 words) - 23:44, 17 July 2024
water-soluble synovial fluid protein. In synovial fluid it interacts with Galectin-3 that improves its lubricating property. Lubricin's unglycosylated regions...
32 KB (3,667 words) - 17:44, 10 April 2024
Chemically Induced Colitis and Augments Inflammatory Responses through Galectin-3". The Journal of Infectious Diseases. 197 (7): 972–980. doi:10.1086/528990...
18 KB (1,690 words) - 01:04, 9 January 2024
Grabski S, Wang JL, Patterson RJ (September 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic...
9 KB (1,120 words) - 02:34, 16 July 2024
malignant follicular thyroid nodules. In conjunction with cyclin A and galectin-3, HK3 could be used as diagnostic biomarker to screen for malignancy in...
15 KB (1,868 words) - 15:32, 1 April 2024
functional roles of galectins in cellular response to membrane damage are rapidly expanding and Deretic's group has recently shown that Galectin-3 recruits ESCRTs...
37 KB (3,926 words) - 00:47, 12 June 2024