Genetic load is the difference between the fitness of an average genotype in a population and the fitness of some reference genotype, which may be either...

w_{\max }}} Genetic load may increase when deleterious mutations, migration, inbreeding, or outcrossing lower mean fitness. Genetic load may also increase...

pulmonary arteries Genetic load, of a population Late-onset Alzheimer's disease (acronym: LOAD), a chronic neurodegenerative disease Parasite load, of an organism...

deleterious then the human species could not survive such a mutation load (genetic load). This led to predictions in the late 1940s by one of the founders...

technique to improve the fitness of captive bred animals. In plants, genetic load can be assessed through a test analogous to an inbreeding depression...

mutations remain in the population longer. H. J. Muller dubbed this "genetic load". Muller, motivated by his concern about the effects of radiation on...

that are closely related genetically. By analogy, the term is used in human reproduction, but more commonly refers to the genetic disorders and other consequences...

These types of malformations are caused by inbreeding depression or genetic load. Island populations often also have small populations due to geographic...

results in an eventual accumulation of mutations known as genetic load. In theory, the genetic load carried by asexual populations eventually becomes so great...

dynamics in a bacterial population reflect tension between adaptation and genetic load". Proceedings of the National Academy of Sciences of the United States...

automatically be expressed, exposing them to natural selection. Thus, the genetic load of deleterious genes is purged relatively quickly. Some hymenopterans...

Jon; Toni, Ivan; Zilles, Karl; Falkai, Peter; Schneider, Frank (2004). "Genetic Load on Amygdala Hypofunction During Sadness in Nonaffected Brothers of Schizophrenia...

A population bottleneck or genetic bottleneck is a sharp reduction in the size of a population due to environmental events such as famines, earthquakes...

the next generation because the offspring are exact genetic clones of their parents. The genetic load of organisms and their populations will increase due...

en. Kuang, W.; Hu, J.; et al. (December 2020). "Genetic diversity, inbreeding level, and genetic load in endangered snub-nosed monkeys (Rhinopithecus)"...

late-acting deleterious mutations was correspondingly small. Therefore, a genetic load of late-acting deleterious mutations could be substantial at mutation–selection...

of understanding whether low neutral genetic diversity is correlated with high genetic drift and high mutation load. In a review of current research, Teixeira...

Genetic rescue is seen as a mitigation strategy designed to restore genetic diversity and reduce extinction risks in small, isolated and frequently inbred...

proteins that according to Kimura would indicate an impossibly high genetic load if the changes were caused by natural selection. The paper was initially...

inbreeding load. This means that, after purging, further inbreeding is expected to be less harmful. The efficiency of purging is reduced by genetic drift and...

to the completely homozygous condition can lead to exposure of their genetic load resulting in an elevated rate of congenital malformations and embryonic...

good fitness indicators, this means that sexual selection increases the genetic load of the offspring of unattractive individuals. Without sexual selection...

PMCID: PMC7857301 Smeds L, Ellegren H. From high masked to high realized genetic load in inbred Scandinavian wolves. Mol Ecol. 2023 Apr;32(7):1567-1580. doi:...

genetics Genetic diversity Founder effect Population bottleneck Genetic drift Inbreeding depression Natural selection Fitness Genetic load The term frequency...

as a courtesy associate professor. Sanford has argued for genetic load in his book Genetic Entropy & the Mystery of the Genome (2005, 2008). In it, he...

population genetic load, which over time will result in extinction. A Vortex: The A vortex is a result of an increase in the impact of genetic drift on...

(September 12, 2007). "Successful Biological Invasion despite a Severe Genetic Load". PLOS ONE. 2 (9): e868. Bibcode:2007PLoSO...2..868Z. doi:10.1371/journal...

computer simulation to understand mutation accumulation dynamics and genetic load. In Shi et al. (Eds.), ICCS 2007, Part II, LNCS 4488 (pp.386-392), Springer-Verlag...

suggests, then it would exceed Haldane's limit. Error catastrophe Genetic drift Genetic load Muller's ratchet Sanford J, Brewer W, Smith F, Baumgardner J (September...

individual cannot appreciably contribute to the next generation because its genetic load is too high. The reduction is smaller for large s because deleterious...