Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. It was discovered by Professors Tun-Hou Lee and Myron...

involves the high-affinity attachment of the CD4 binding domains of gp120 to CD4. Once gp120 is bound with the CD4 protein, the envelope complex undergoes a...

through its viral envelope protein known as gp120. The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor...

homotrimer, and is cleaved into gp120 and gp41 by the host cell protease, furin. To form an active fusion protein, SU gp120 and TM gp41 polypeptides remain...

can bind, through the gp120 and gp41 proteins on its surface. HIV also requires a second co-receptor along with the CD4-gp120 complex to enter the target...

Auffray C (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–128. doi:10.1007/BF00211424. PMID 1869305...

of the escape pathways can be utilized to design immunogens. The region gp120 of HIV-1 Env which contacts CD4, its primary receptor, is functionally conserved...

on the surface of the virion and consists of a trimer of Gp120-Gp41 hetero-dimers. The Gp120 envelope protein is a chemokine mimic. Though it lacks the...

envelope glycoprotein (Env) of HIV, a trimer formed by heterodimers of gp120 and gp41. Env is responsible for binding to its primary host receptor, CD4...

gp120 to the CD4 receptor A conformational change in gp120, which both increases its affinity for a co-receptor and exposes gp41 The binding of gp120...

et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507...

other viruses. Furthermore, the functionally important epitopes of the gp120 protein are masked by glycosylation, trimerisation and receptor-induced...

et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507...

CCR5 antagonist, a CD4 T lymphocyte (CD4) post-attachment inhibitor, and a gp120 attachment inhibitor. There are also two drugs, ritonavir (RTV) and cobicistat...

molecule, which induces a change in the conformation of gp120. This change in conformation allows the gp120 complex to interact with the chemokine co-receptor...

much attention as a potential target for HIV vaccines. Gp41 is coded with gp120 as one gp160 by the env gene of HIV. Gp160 is then extensively glycosylated...

gp120 libraries led to one that strongly bound both an original antibody and the mature bNAb that evolved from it. Giving patients a modified gp120 that...

limited range of human leucocytes. This is because its surface protein, gp120, specifically interacts with the CD4 molecule—a chemokine receptor—which...

clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor...

the primate lentiviruses).[which?] Structural proteins listed by size: Gp120 surface envelope protein SU, encoded by the viral gene env. 120000 Da (daltons)...

replication throughout the body. HIV can enter the macrophage through binding of gp120 to CD4 and second membrane receptor, CCR5 (a chemokine receptor). Both circulating...

cells. While natural anti-gp120 antibodies exhibit a response towards uninfected CD4-expressing cells that have a soluble gp120 bound to the CD4 on the...

Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929...

Gerard C (June 1998). "Structural interactions between chemokine receptors, gp120 Env and CD4". Seminars in Immunology. 10 (3): 249–57. doi:10.1006/smim.1998...

Human Immunodeficiency Virus(HIV) (most commonly on the envelope protein gp120) that elicits antibodies with neutralizing activity. V3 loop Human Immunodeficiency...

Immunodeficiency Virus Type 1 Attachment to HeLa CD4 Cells Is CD4 Independent and gp120 Dependent and Requires Cell Surface Heparans". Journal of Virology. 72 (5):...

an HLA-B serotype IgG1-b12, an antibody against the HIV surface protein gp120 found in some long-term nonprogressors 12B (disambiguation) This disambiguation...

: 318–25  These are protein complexes formed by two proteins, gp41 and gp120, both expressed from the env gene, collectively forming a spike protein...

Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929...

studies have shown that cryptic epitopes can be revealed or exposed when HIV gp120 binds to CD4. Regenmortel, Marc (2008). "Antigenicity and Immunogenicity...