Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death...

Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells....

Granzyme A (GzmA, EC 3.4.21.78, CTLA3, HuTPS, T-cell associated protease 1, cytotoxic T lymphocyte serine protease, TSP-1, T-cell derived serine proteinase)...

Granzyme K (GrK) is a protein that is encoded by the GZMK gene on chromosome 5 in humans. Granzymes are a family of serine proteases which have various...

(IP-10, lymphotactin), trigger cytolysis of target cells (perforins, granzymes...), and interact with other cells, such as epithelial cells, monocytes...

(subscription required) Jonsson AH, Zhang F, Dunlap G, et al. (June 2022). "Granzyme K+ CD8 T cells form a core population in inflamed human tissue". Science...

passive diffusion of a family of pro-apoptotic proteases, known as the granzymes, into the target cell. The lytic membrane-inserting part of perforin is...

American television production company Gamma-ray burst, an astronomical event Granzyme B (GrB), serine protease most commonly found in the granules of NK cells...

increases cytotoxic activity by increasing the expression of perforin, granzyme B, Fas ligand, and TNF. In T cells, the activation of the JNK pathway by...

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer...

collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M. GRCh38: Ensembl...

protease Granzyme B, cytotoxic T-cells and NK cells are able to induce apoptosis in target cell. SCs produce PI-9 that irreversibly bonds Granzyme B and...

Necroptosis can be triggered by activated T cells – which secrete toxic granzymes and perforin – or indirectly as a result of reduced blood flow or the...

Granzyme H is a protein that in humans is encoded by the GZMH gene. GRCh38: Ensembl release 89: ENSG00000100450 – Ensembl, May 2017 GRCm38: Ensembl release...

the cytotoxic granule protease granzyme B. In doing so, Serpin B9 may protect against inadvertent release of granzyme B and premature or unwanted activation...

influence of blood pressure. Other reports have suggested the serine protease granzyme B may contribute to aortic aneurysm rupture through the cleavage of decorin...

associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis...

cell will immediately come to "inject" lymphotoxins, such as perforin or granzyme, that will kill the infected T helper cell. However, if T helper cells...

granules that contains proteins involved in cell lysis such as perforin and granzyme B. Flow cytometry is also commonly used. Bone marrow involvement in this...

macrophages, or neutrophils are the primary cells recruited, release of granzymes and other killing factors if NK cells or neutrophils are recruited, and...

"Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction"...

latter's Fc regions interact with their Fc receptors, releasing perforin and granzyme B to kill the tumor cell. Examples include rituximab, ofatumumab, elotuzumab...

their cytoplasm contain proteins such as perforin and proteases known as granzymes. Upon release in close proximity to a cell slated for killing, perforin...

Glycolic acid Glycolipid Glycoprotein Gonadotropin-releasing hormone (GnRH) Granzyme Green fluorescent protein Growth factor Growth hormone Growth hormone-releasing...

cell death through release of a number of molecules, including perforin, granzyme B, and granulysin. Other agents, including tumor necrosis factor alpha...

granules. Cytotoxic T cells and NK cells release molecules like perforin and granzymes by a process of directed exocytosis to kill infected target cells. Basophil...

through its association with a protein complex that forms apoptosome, or by granzyme B, or via the death receptor pathways. Autoproteolysis takes place in some...

Thrombospondin 1, a protein that in humans in encoded by the THBS1 gene Granzyme A, an enzyme class This disambiguation page lists articles associated with...

angiogenesis, blood coagulation, abolishing detachment activity by GrB (Granzyme B), and tumour metastasis. HS has also been shown to serve as cellular...

flow into the infected cell, and causing it to burst or lyse. CTL release granzyme, a serine protease encapsulated in a granule that enters cells via pores...