• Thumbnail for HLA-DR
    HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human...
    31 KB (2,293 words) - 12:25, 28 December 2023
  • Thumbnail for Human leukocyte antigen
    The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation...
    51 KB (5,942 words) - 15:58, 25 September 2024
  • Thumbnail for HLA-DRB1
    encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at...
    6 KB (677 words) - 21:44, 22 October 2024
  • Thumbnail for HLA-DR1
    HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians. The serology for the...
    20 KB (1,596 words) - 01:46, 28 November 2023
  • Thumbnail for MHC class II
    MHC class II (redirect from Hla-d antigens)
    gene complex (HLA). HLAs corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR. Mutations in the HLA gene complex can...
    16 KB (2,022 words) - 10:24, 1 August 2024
  • Thumbnail for HLA-DR4
    HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles...
    26 KB (2,119 words) - 03:34, 29 November 2023
  • Thumbnail for HLA-DRA
    HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit...
    9 KB (1,145 words) - 03:20, 25 December 2023
  • Thumbnail for HLA-DQ
    The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different isoforms of DQ can bind to and...
    36 KB (2,596 words) - 22:31, 6 November 2024
  • (see protein boxes on right for links). Less is known about HLA-DP relative to HLA-DQ and HLA-DR but the sequencing of DP types and determination of more...
    10 KB (905 words) - 09:55, 10 April 2023
  • Thumbnail for HLA-DR3
    HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western...
    9 KB (697 words) - 02:42, 27 January 2024
  • Thumbnail for Rheumatoid arthritis
    and outcome for rheumatoid arthritis (RA) may associate with particular HLA-DR alleles, but these alleles vary among ethnic groups and geographic areas...
    149 KB (16,151 words) - 17:55, 8 November 2024
  • Thumbnail for Sjögren syndrome
    syndrome. Studies on the polymorphisms of human leukocyte antigen (HLA)-DR and HLA-DQ gene regions in Sjögren's patients show differential susceptibility...
    87 KB (9,205 words) - 08:53, 10 November 2024
  • Thumbnail for Chromosome 6
    HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3) HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 forms HLA-DR,...
    35 KB (2,420 words) - 20:57, 24 August 2024
  • Thumbnail for HLA-DR15
    HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central...
    16 KB (1,100 words) - 13:55, 26 March 2024
  • Thumbnail for CD74
    HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is...
    19 KB (2,221 words) - 07:18, 15 October 2024
  • Thumbnail for HLA-DR2
    HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This...
    4 KB (333 words) - 09:16, 3 April 2024
  • Thumbnail for HLA-DQ8
    HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined...
    67 KB (5,460 words) - 15:43, 3 July 2024
  • Thumbnail for HLA-DQ1
    HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was...
    19 KB (1,482 words) - 03:28, 19 October 2022
  • Thumbnail for HLA-A
    HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is a major histocompatibility...
    27 KB (3,411 words) - 01:57, 10 March 2024
  • Thumbnail for HLA-DQ2
    HLA-DQ2 (DQ2) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains...
    33 KB (3,380 words) - 17:14, 6 July 2024
  • Thumbnail for HLA-DRB3
    HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. The protein encoded by this gene...
    9 KB (1,108 words) - 23:50, 12 August 2023
  • Thumbnail for HLA-DRB4
    histocompatibility complex, class II, DR beta 4, also known as HLA-DRB4, is a human gene. The protein encoded by this gene belongs to the HLA class II beta chain paralogues...
    8 KB (1,020 words) - 02:54, 25 December 2023
  • Thumbnail for Major histocompatibility complex
    most studied HLA genes are the nine classical MHC genes: HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, and HLA-DRB1. In humans...
    58 KB (6,785 words) - 20:25, 21 September 2024
  • Goldmann S (2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based on over 13,000 German blood donors". Hum Immunol. 64 (1):...
    13 KB (1,237 words) - 01:13, 1 June 2024
  • Thumbnail for Type 1 diabetes
    from the human leukocyte antigen (HLA) region on chromosome 6p21. The HLA class II genes, particularly HLA-DR and HLA-DQ, are the strongest genetic determinants...
    108 KB (12,613 words) - 02:16, 10 November 2024
  • Thumbnail for Hashimoto's thyroiditis
    Peters H, Schmieg D, Mayr WR, Usadel KH, Schleusener H (January 1992). "HLA-DR/DQ gene variation in nongoitrous autoimmune thyroiditis at the serological...
    72 KB (7,888 words) - 02:12, 28 August 2024
  • non-self epitope on one of their various HLA protein forms (HLA-A, HLA-B, HLA-C, HLA-DM, HLA-DO, HLA-DP, HLA-DQ, or HLA-DR) can bind to a T-cell receptor and...
    56 KB (5,871 words) - 00:47, 10 November 2024
  • Thumbnail for HLA-DM
    complex (MHC) class II membrane-bound proteins. HLA-DM is encoded by the genes HLA-DMA and HLA-DMB. HLA-DM is a molecular chaperone that works in lysosomes...
    19 KB (2,371 words) - 10:20, 27 October 2024
  • Thumbnail for Graft-versus-host disease
    leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors"...
    39 KB (4,442 words) - 15:41, 17 October 2024
  • cell that an antigen is inside the cell. MHC Class II molecules—HLA-DR, and HLA-DQ and HLA-DP—are only present on antigen presenting cells and are responsible...
    16 KB (1,897 words) - 12:38, 16 September 2023