Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. The...
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The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants...
13 KB (1,234 words) - 02:29, 15 August 2024
Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A...
54 KB (6,141 words) - 03:36, 18 August 2024
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective...
19 KB (1,978 words) - 11:32, 1 May 2024
Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. It...
17 KB (1,672 words) - 02:28, 15 August 2024
Orexin-A, also known as hypocretin-1, is a naturally occurring neuropeptide and orexin isoform. The orexinergic nucleus in the lateral hypothalamus is...
5 KB (653 words) - 05:33, 8 December 2023
Neuropeptide FF receptor 1 (NPFFR1, FF1R) Neuropeptide FF receptor 2 (NPFFR2, FF2R) Orexin receptor InterPro: IPR000204 Hypocretin (orexin) receptor 1 (HCRTR1...
25 KB (2,172 words) - 01:01, 29 November 2023
Narcolepsy (redirect from Type 1 narcolepsy)
disorder in humans by either modifying the Hypocretin/Orexin receptors or by eliminating this peptide. An orexin deficit caused by the degeneration of hypothalamic...
71 KB (8,196 words) - 12:40, 14 July 2024
Cataplexy (section Hypocretin)
destruction of hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of...
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Lateral hypothalamus (redirect from Orexin system)
"Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors". Biochemical...
27 KB (3,032 words) - 13:35, 14 November 2023
"Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors". Biochemical...
67 KB (7,709 words) - 06:15, 27 May 2024
Lambe EK, Liu RJ, Aghajanian GK (November 2007). "Schizophrenia, hypocretin (orexin), and the thalamocortical activating system". Schizophrenia Bulletin...
87 KB (9,542 words) - 16:05, 16 August 2024
Suvorexant (category Orexin antagonists)
antagonist of the orexin (hypocretin) receptors OX1 and OX2. These receptors are the biological targets of the endogenous wakefulness-promoting orexin neuropeptides...
94 KB (8,956 words) - 03:07, 14 August 2024
CVN45502 (category Orexin antagonists)
CVN45502 is a selective hypocretin (orexin) receptor 1 antagonist. It significantly reduces food intake and body weight in a mouse model of obesity. Although...
4 KB (178 words) - 18:38, 14 February 2024
Daridorexant (category Orexin antagonists)
The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Daridorexant...
48 KB (4,078 words) - 11:27, 24 July 2024
Lemborexant (category Orexin antagonists)
The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Lemborexant has...
21 KB (1,687 words) - 04:21, 27 January 2024
"Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors". Biochemical...
47 KB (4,229 words) - 19:27, 10 August 2024
Tebideutorexant (category Orexin antagonists)
PMC 8055642. PMID 33889031. Jacobson LH, Hoyer D, de Lecea L (May 2022). "Hypocretins (orexins): The ultimate translational neuropeptides". J Intern Med. 291 (5):...
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Pediatric narcolepsy (section Type 1 narcolepsy)
tuberomammillary nucleus contain orexin receptors, are projected to by orexin cells and are known to be involved in wakefulness. The orexin cells in the lateral hypothalamus...
29 KB (2,856 words) - 20:29, 3 April 2024
sensed by glucose-inhibited neurons in the lateral hypothalamus. These orexin-expressing neurons appear to be hyperpolarised (inhibited) by a glucose-activated...
17 KB (1,778 words) - 16:33, 21 March 2024
Danavorexton (category Orexin receptor agonists)
investigational sleep drugs § Orexin receptor agonists Jacobson LH, Hoyer D, de Lecea L (January 2022). "Hypocretins (orexins): The ultimate translational...
5 KB (301 words) - 11:39, 13 January 2024
Seltorexant (category Orexin antagonists)
§ Orexin receptor antagonists List of investigational sleep drugs § Orexin receptor antagonists Sun Y, Tisdale RK, Kilduff TS (2021). "Hypocretin/Orexin...
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Amphetamine (redirect from 1-Phenyl-2-Aminopropane)
lack of hypocretin (orexin) of likely an autoimmune origin. In these cases, once the disease is established, the majority of the 70,000 hypocretin-producing...
273 KB (26,879 words) - 20:36, 4 August 2024
lack of hypocretin (orexin) of likely an autoimmune origin. In these cases, once the disease is established, the majority of the 70,000 hypocretin-producing...
49 KB (6,133 words) - 17:01, 26 July 2024
Firazorexton (category Orexin receptor agonists)
Nonproprietary Name; development code TAK-994) is an experimental orexin 2 (OX2) receptor agonist first described in a 2019 patent filed by Takeda Pharmaceutical...
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the hypocretin (orexin) receptor 2 cause canine narcolepsy, and that human narcolepsy was caused by an immune mediated destruction of the hypocretin (orexin)...
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of hypocretin-1 to activate the ERK signaling was observed when CB1 and HcrtR1 were co-expressed ... In this study, a higher potency of hypocretin-1 to...
21 KB (2,477 words) - 09:59, 9 February 2024
ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice Decline of CSF orexin (hypocretin) levels in Prader-Willi...
6 KB (558 words) - 00:45, 7 January 2024
"Distribution of orexin/hypocretin in the rat median eminence and pituitary". Brain Research. Molecular Brain Research. 76 (1): 1–6. doi:10.1016/s0169-328x(99)00317-4...
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Neurotransmitter (redirect from Receptors, neurotransmitter)
PMC 3367503. PMID 21729715. Orexin receptor antagonists a new class of sleeping pill, National Sleep Foundation. "Acetylcholine Receptors". Ebi.ac.uk. Retrieved...
94 KB (8,341 words) - 08:44, 9 August 2024