transcriptional activator is a protein that in humans is encoded by the IFI16 gene. This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible...

leucine-rich repeat-containing receptors), AIM2 (absent in melanoma 2), IFI16 (IFN-inducible protein 16), and pyrin. Through their caspase activation...

Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC (January 2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected...

Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, et al. (January 2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected...

gamma-interferon-inducible protein 16 (IFI16), which produces an innate immune response against the virus by activating caspase 1 in IFI16 inflammasomes and inducing...

competition for dsDNA binding. A novel transcript isoform of human IFI16-designated IFI16-β has been also shown to inhibit the AIM2 inflammasome assembly...

and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses...

NOD-like Leucine Rich Repeats (NLRs), AIM2-Like Receptors (ALRs), Pyrin and IFI16. These proteins allow caspase-1 activation by forming a multiprotein activating...

Xin; Doitsh, Gilad; Krogan, Nevan J.; Greene, Warner C. (2014-01-24). "IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T-cells Abortively Infected...

stranded DNA. Two ALRs with pyrin domains, AIM2 and IFI16, assemble inflammasomes; AIM2 in the cytosol and IFI16 moves between the nucleus and cytosol functioning...

Knipe, D. M. (2012). "Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein". Proceedings...

of infected cells. Several DNA sensors, such as DAI, RNA polymerase III, IFI16, DDX41 and cGAS, can detect foreign nucleic acids. After recognizing viral...

tumor development. The IFI16 protein modulates p53 functioning and inhibits cell proliferation in the RAS/RAF signaling pathway. IFI16 has a high binding...

HGNC:24970 Q0D2I5 7423 IFFO2 HGNC:27006 Q5TF58 7424 IFI6 HGNC:4054 P09912 7425 IFI16 HGNC:5395 Q16666 7426 IFI27 HGNC:5397 P40305 7427 IFI27L1 HGNC:19754 Q96BM0...

PMID 24356306. Monroe, KM; Yang, Z; Johnson, JR; et al. (January 2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected...

nuclear phosphoprotein Humans have an ifi202 and ifi204 similar gene known as ifi16. They share some similarities in the amino acid sequence. Ifi202 is known...

Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC (January 2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected...

Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC (January 2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected...