Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. For colon...

active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro...

which incorporates into the DNA molecule and stops synthesis; and IRI – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling...

Europe during the Cold War. Atropine has been observed to prevent or treat irinotecan induced acute diarrhea. Adverse reactions to atropine include ventricular...

effectiveness to prevent diarrhea in cancer patients who have received irinotecan. It can interfere with the absorption of some medications, and lead to...

]] [[ ]] [[ ]] [[ ]] |alt=Irinotecan Pathway edit]] The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229". Glucuronosyltransferase...

under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan. C. acuminata also contains the chemical compounds...

colorectal cancer who received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type and medically...

inhibitors. One of the first inhibitors shown to target TOP1 is irinotecan. Irinotecan is an analogue of the cytotoxic natural alkaloid camptothecin, obtained...

Romidepsin Vorinostat Zabadinostat Belotecan Camptothecin Exatecan Gimatecan Irinotecan Topotecan Etoposide Teniposide Tafluposide Bortezomib Erlotinib Gefitinib...

antineoplastic agent, which inhibits DNA repair and/or DNA synthesis; IRI – irinotecan (Camptosar), a topoisomerase inhibitor, prevents DNA from uncoiling and...

Aflibercept (Zaltrap), in combination with fluorouracil, leucovorin, and irinotecan (known as FOLFIRI), is indicated for the treatment of people with metastatic...

include a combination of chemotherapy (paclitaxel and carboplatin or irinotecan plus cisplatin) and surgical resection in ovarian clear-cell carcinoma;...

with severe diarrhea and neutropenia in patients who are treated with irinotecan, which is metabolized by UGT1A1. While paracetamol (acetaminophen) is...

which incorporates into the DNA molecule and stops DNA synthesis; IRIN – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling...

generic versions of intravenous oncology products such as Paclitaxel, Irinotecan, Oxaliplatin, Gemcitabine, Cytarabine, Carboplatin, Topotecan, Docetaxel...

nucleotides Daunorubicin, Doxorubicin, Epirubicin Enzyme inhibitors inhibit enzymes that are crucial to DNA replication Decitabine, Etoposide, Irinotecan...

a topoisomerase I inhibitor. Chemically, it consists of four units of irinotecan (a topoisomerase I inhibitor in use since the late 1990s) linked by carboxymethyl...

(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...

compare the efficacy of Abituzumab, cetuximab, and irinotecan compared to cetuximab and irinotecan in patients with KRAS (exon 2) wild-type metastatic...

for a small number of drugs that are very toxic to the intestine (e.g. irinotecan), these molecules which would not otherwise be very toxic can become so...

4 mg/kg intravenously every three weeks or physician's choice of either irinotecan or paclitaxel monotherapy. Efficacy was based on DESTINY-Breast03 (NCT03529110)...

have been approved and are used in cancer chemotherapy today: topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin has also been found...

topotecan (TPT), irinotecan, and belotecan. TPT is commonly used to treat ovarian and small cell lung cancer (SCLC) while irinotecan is known to improve...

(2004). "A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic...

(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...

chemotherapeutic – cisplatin or carboplatin – combined with either etoposide or irinotecan. This is typically combined with thoracic radiation therapy – 45 Gray...

chemotherapy is given the FOLFIRINOX regimen containing fluorouracil, irinotecan, oxaliplatin and leucovorin has been shown to extend survival beyond traditional...

such as irinotecan. This effect is derived from the microbiome-encoded β-glucuronidase enzymes which recover the active form of the irinotecan causing...

(5-FU), up to 40% get mucositis, and 10–15% get grade 3–4 oral mucositis. Irinotecan is associated with severe GI mucositis in over 20% of patients. Seventy-five...