Krüppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs...

The following human genes encode Kruppel-like factors: KLF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15,...

that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors...

induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create pluripotent (iPS) cells from adult...

group published that three Yamanaka transcription factors, Oct4, Sox2, and Klf4, when delivered together in a virus, could safely reverse the age of human...

the primed pluripotent stem cell a reprogramming factor Klf4, or Sox2 and Klf4 (SK cocktail). Klf4 alone can reset mouse primed cells, but SK is needed for...

polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9) Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4) Fibroblasts → neural...

but could in the end reduce it to four transcription factors – Sox2, Oct4, Klf4 and c-Myc. The 2012 Nobel Prize in Physiology or Medicine was awarded jointly...

ENSG00000109787 C2H2 ZF Known motif – High-throughput in vitro [468] RRCCRCGCCCH KLF4 ENSG00000136826 C2H2 ZF Known motif – High-throughput in vitro [469] VCCACRCCCH...

2006 using mouse fibroblasts and four transcription factors, Oct4, Sox2, Klf4 and c-Myc; this technique, called reprogramming, later earned Shinya Yamanaka...

used to create induced pluripotent stem cells (iPSCs), together with Sox2, Klf4, and often c-Myc (OSKM) in mice, demonstrating its capacity to induce an...

are present in about one-fourth of meningiomas. Mutations in the TRAF7, KLF4, AKT1, and SMO genes are commonly expressed in benign skull-base meningiomas...

return to a 'stem-like' state alongside transcription factors Oct4, Sox2 and Klf4. It has since been shown that it is possible to generate iPSCs without c-Myc...

cells are generated by the transcription factors Myc, Oct3/4, Sox2, and Klf4. Sophie M. Worobec (2008). "Treatment of leprosy/Hansen's disease in the...

University. They used the transcription factors Oct3/4, Sox2, c-Myc, and Klf4 to reprogram mouse fibroblast cells into pluripotent cells. Subsequent work...

studies have revealed several mechanosensitive genes, such as HoxA5, Klf3, and Klf4, whose promoters were hypermethylated by disturbed blood flow, but rescued...

B, Lee JE, Ge K (January 2017). "Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor γ in Adipogenesis"...

discovered, could be recapitulated (in mice) by defined factors (Oct4, Sox2, Klf4, and c-Myc) to generate induced pluripotent stem cells (iPSCs). Other combinations...

This retroviral expression of four transcriptional factors (Oct4, Sox2, Klf4 and c-Myc; OSKM) induces pluripotency in somatic cells. This is supported...

can be induced by the delivery of four factors (Oct3/4, Sox2, c-Myc, and Klf4) to differentiated cells. Utilizing the four genes previously listed, the...

Cherepanova OA, Salmon M, Alencar GF, Haskins RM, et al. (June 2015). "KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in...

Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression". Circulation Research. 124 (8): 1240–1252. doi:10.1161/CIRCRESAHA...

December A gene therapy based on three transcription factors, Oct4, Sox2, and Klf4 (OSK), is shown to provide sustained vision recovery in mice affected by...

downstream of the JAK-STAT signaling pathway and subsequent activation of Klf4 (a member of the family of Kruppel-like factors). Oct-4, Sox2 and Nanog positively...

AAV2-induced transient expression of the reprogramming genes Oct4, Sox2, and Klf4 (OSK) could reverse retinal aging and restore visual function in mice. Given...

stem cell-like state by the introduction of four factors (Oct3/4, Sox2, Klf4, and c-Myc). iPS cells have the ability to self-renew indefinitely and contribute...

fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4". Proceedings of the National Academy of Sciences of the United States of...

HGNC:6345 Q13351 8217 KLF2 HGNC:6347 Q9Y5W3 8218 KLF3 HGNC:16516 P57682 8219 KLF4 HGNC:6348 O43474 8220 KLF5 HGNC:6349 Q13887 8221 KLF6 HGNC:2235 Q99612 8222...

somatic cell reprogramming, can be achieved by ectopic expression of Oct4, Klf4, Sox2, and c-Myc (OKSM). Upon induction, mouse fibroblasts must undergo MET...

embryonic state, which relies on the transcription factors Oct4, Sox2, Myc, and Klf4. cellular senescence centimorgan (cM) A unit for measuring genetic linkage...