Cardiolipin (IUPAC name 1,3-bis(sn-3’-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial...
32 KB (3,791 words) - 18:56, 19 August 2024
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid...
5 KB (486 words) - 01:52, 12 August 2023
with anti-mitochondrial antibodies have been identified. M1 – cardiolipin (Anti-cardiolipin antibodies, ACA) M2 – branched-chain alpha-keto acid dehydrogenase...
5 KB (500 words) - 10:03, 21 October 2023
musculature and muscle weakness, growth delay, exercise intolerance, cardiolipin abnormalities, and 3-methylglutaconic aciduria. It can be associated...
16 KB (1,660 words) - 10:16, 18 May 2024
extract of ox heart (diphosphatidyl glycerol). It therefore detects anti-cardiolipin antibodies (IgG, IgM or IgA), visualized through foaming of the test...
6 KB (670 words) - 13:13, 24 January 2024
against substances released by cells when they are damaged by T. pallidum (cardiolipin and lecithin). Traditionally, syphilis serologic testing has been performed...
5 KB (532 words) - 15:02, 5 March 2024
detect lupus anticoagulant, anti-apolipoprotein antibodies, and/or anti-cardiolipin antibodies. Antiphospholipid syndrome can be primary or secondary. •...
37 KB (3,944 words) - 04:58, 16 August 2024
after an ischemia and prevent cardiolipin from being catabolized by phospholipase A2. It can also work to restore cardiolipin levels in the inner mitochondrial...
19 KB (1,857 words) - 18:39, 11 June 2024
CDP-DAG forming cardiolipin releasing CMP by the action of cardiolipin synthase.[citation needed] Two phosphatidylglycerols form cardiolipin, the constituent...
4 KB (456 words) - 08:50, 30 June 2024
phospholipid:diacylglycerol acyltransferases). It catalyzes remodeling of immature cardiolipin to its mature composition containing a predominance of tetralinoleoyl...
58 KB (6,767 words) - 17:30, 31 July 2024
MTP did indeed have cardiolipin remodeling capabilities. This suggests a possible link between mitochondrial membrane cardiolipin content and beta oxidation...
6 KB (589 words) - 15:55, 17 May 2024
reduce the production of toxic reactive oxygen species and stabilize cardiolipin. Stealth Peptides, a privately held company, was founded in 2006 to develop...
5 KB (208 words) - 04:15, 3 April 2023
mitochondrial ROS production is stimulated, and cardiolipin is oxidized by a peroxidase function of the cardiolipin–cytochrome c complex. The hemoprotein is...
33 KB (3,823 words) - 05:09, 22 July 2024
Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered in cow hearts in 1942, and...
166 KB (18,360 words) - 18:19, 4 August 2024
homodimer. This is required for activity. Dimers are connected by a cardiolipin molecule, which has been found to play a key role in stabilization of...
36 KB (3,606 words) - 08:27, 15 July 2024
particular requires the presence of cardiolipin, a unique mitochondrial lipid. In yeast mitochondria lacking cardiolipin, the number of enzymes forming respiratory...
15 KB (1,566 words) - 05:23, 4 January 2024
mitochondria and chloroplasts, and also bacterial cell membranes; and that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell...
70 KB (7,517 words) - 19:12, 17 July 2024
biosynthesis of cardiolipin in mitochondria, and its overexpression in cultured cells resulted in increased cardiolipin synthase activity. As cardiolipin is synthesized...
16 KB (1,688 words) - 00:01, 8 June 2024
anticoagulant-positive". Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis.[citation...
119 KB (13,047 words) - 02:23, 25 July 2024
Sodium oxide (NaO) Nonyl Acridine Orange, a fluorescent die. It can stain cardiolipin content of mitochondria. North Atlantic oscillation, a climatic phenomenon...
1 KB (218 words) - 20:16, 7 October 2023
monolysocardiolipin (MLCL) into cardiolipin. In 1990, biologists Michael Schlame and Bernd Rustow observed the deacylation of cardiolipin into MLCL, which was then...
6 KB (635 words) - 17:47, 7 July 2024
ATP synthases, but the FO subcomplex has many unique subunits. It uses cardiolipin. The inhibitory IF1 also binds differently, in a way shared with trypanosomatida...
33 KB (3,752 words) - 15:11, 10 June 2024
acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin". The Journal of Biological Chemistry. 278 (34): 31861–31870. doi:10...
91 KB (10,659 words) - 18:05, 21 August 2024
generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and diagnostic criteria require one clinical event (i.e....
16 KB (1,868 words) - 01:25, 2 August 2024
blood or cerebrospinal fluid is taken and introduced to the antigen – cardiolipin extracted from bovine muscle or heart. Syphilis non-specific antibodies...
6 KB (483 words) - 15:10, 24 January 2024
knee Anterior cruciate ligament injury, a common sports injury Anti-cardiolipin antibodies ATP citrate synthase, or ATP citrate lyase, an enzyme ACL...
2 KB (320 words) - 10:06, 29 July 2024
phospholipid composition. Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%. In S. cerevisiae mitochondria,...
8 KB (908 words) - 22:54, 15 February 2024
PLSCR3 (section Effect on mitochondrial cardiolipin)
that cardiolipin is a likely player in mitochondrial apoptosis. In a study done by R Lee et al., it was found that during apoptosis, cardiolipin in the...
8 KB (1,032 words) - 07:16, 3 June 2024
the APOH gene. One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure...
12 KB (1,419 words) - 19:08, 13 August 2023
erythematosus but often detected in people without the disease), anti-cardiolipin antibodies, and anti-β2-glycoprotein 1 antibodies; it is therefore regarded...
47 KB (5,604 words) - 14:51, 4 August 2024