The following is a list of phosphodiesterase inhibitors. Adibendan Aminophylline Aminophylline dihydrate Amipizone Apremilast Arofylline Atizoram Befuraline...

other early PDE5 inhibitors. PDE5 is an enzyme that accepts cGMP and breaks it down. Sildenafil, vardenafil and tadalafil are inhibitors of this enzyme, which...

contrasted with the selective serotonin reuptake inhibitors (SSRIs) and norepinephrine reuptake inhibitors (NRIs), which act upon single neurotransmitters...

based on their unique mechanisms of action: cardiac glycosides, beta-adrenergic agonists, phosphodiesterase III inhibitors, and calcium sensitizers. It is...

(October 2013). "Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud's phenomenon: systematic review and meta-analysis of randomised trials"...

20–50% decrease in clearance. The inhibitors of CYP3A4 are the following substances. boceprevir, protease inhibitors: ritonavir, indinavir, nelfinavir...

platelets, and low white blood cells. Cilostazol is a phosphodiesterase 3 inhibitor which works by inhibiting platelet aggregation and dilating arteries. Cilostazol...

treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Xanthine...

Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known. At the site of application...

Doxofylline (also known as doxophylline) is a phosphodiesterase inhibiting bronchodilator used in the treatment of chronic respiratory diseases such as asthma...

Hou X, et al. (August 2009). "Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate...

Marques F (February 2020). "Risk of nonarteritic ischaemic optic neuropathy with phosphodiesterase type 5 inhibitors: a systematic review and meta-analysis"...

is orally active and acts as a selective phosphodiesterase-4 inhibitor. Phosphodiesterase (PDE) inhibitors, such as theophylline, have been used to treat...

the treatment of certain types of psoriasis and psoriatic arthritis. The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). It...

developmental human drugs that selectively inhibit cyclic nucleotide phosphodiesterases. His investigations on the modulation of adrenergic responses in the pineal...

2′,3′-Cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37, CNPase, systematic name nucleoside-2′,3′-cyclic-phosphate 2′-nucleotidohydrolase) is an enzyme...

pyrophosphatase/phosphodiesterase family member 1 (PC-1, CD203a) is an enzyme that in humans is encoded by the ENPP1 gene. This gene is a member of the ecto-nucleotide...

the first JAK inhibitor, ruxolitinib, to treat a skin condition. Some JAK1 inhibitors are based on a benzimidazole core. JAK3 inhibitors target the catalytic...

It is structurally related to papaverine, and is a selective inhibitor of phosphodiesterase-4, and has no anticholinergic effects. It is available in Asia...

cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene. The PDE4D gene is complex and has at least 9...

oxidase inhibitor. (DAAO is a pathway to NMDAR.) MK-8189 – phosphodiesterase 10A inhibitor. Osoresnontrine (BI-409306, SUB-166499) – phosphodiesterase 9A inhibitor...

(2002). "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors". Clin. Exp. Immunol. 128...

One treatment for erectile dysfunction is cGMP-specific phosphodiesterase type 5 inhibitors, which enable patients to resume having sex despite having...

phosphodiesterase 3 inhibitor used to manage heart failure in dogs pirlimycin – antimicrobial ponazuril – anticoccidial praziquantel – treatment of infestations...

Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2), is an enzyme that in humans is encoded by the ENPP2...

vasodilator used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease...

5-HT1A receptor antagonist Rolipram (ME-3167; ZK-62711) – phosphodiesterase 4 (PDE4) inhibitor Sabcomeline (BCI-224; CEB-242; Memric; SB-202026) – muscarinic...

pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and...

serotonin reuptake inhibitors (SSRIs) or norepinephrine reuptake inhibitors, while a person suffering from loss of energy and enjoyment of life would take...

45 (3): 201–12. doi:10.1024/0301-1526/a000526. PMID 27129065. Phosphodiesterase inhibitors (e.g., sildenafil) can also improve [Raynaud's phenomenon] symptoms...