Melanocortin 4 receptor (redirect from MC4R)
Melanocortin 4 receptor (MC4R) is a melanocortin receptor that in humans is encoded by the MC4R gene. It encodes the MC4R protein, a G protein-coupled...
33 KB (3,164 words) - 08:06, 10 March 2024
MC3R and MC4R are primarily expressed in the brain and regulate energy homeostasis. MC3R is additionally involved in immunomodulation while MC4R has a role...
12 KB (1,639 words) - 01:40, 18 December 2023
with childhood growth, accrual of lean mass and onset of puberty. MC4R. Defects in MC4R are a cause of autosomal dominant obesity, accounting for 6% of...
10 KB (1,143 words) - 18:46, 8 November 2023
ASIP appear naturally in humans and bind melanocortin receptors 4 and 1 (Mc4R and Mc1R), respectively, with nanomolar affinities. The opioid antagonists...
11 KB (1,120 words) - 05:43, 29 February 2024
include: Leptin deficiency Leptin receptor deficiency Melanocortin-4 receptor (MC4R) Proopiomelanocortin (POMC Prohormone convertase 1/3 (PC1/3) SIM1 BDNF NTRK2...
1 KB (133 words) - 12:06, 21 July 2024
P, Brychta RJ, et al. (April 2015). "RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals". The...
18 KB (1,411 words) - 16:59, 19 August 2024
David; Scott, James; Kooner, Jaspal S (2008). "Common genetic variation near MC4R is associated with waist circumference and insulin resistance". Nature Genetics...
8 KB (591 words) - 09:24, 27 August 2024
receptor Melanocortin receptor: MC1R, MC2R (a.k.a. ACTH receptor), MC3R, MC4R, MC5R Olfactory receptors, through Golf in the olfactory neurons Parathyroid...
6 KB (719 words) - 12:10, 31 July 2024
projections from the arcuate nucleus seem to exert their effect on appetite via MC4R-expressing oxytocinergic cells of the PVN. Inputs from suprachiasmatic nucleus...
13 KB (1,332 words) - 23:04, 16 September 2024
nonselectively, with the highest affinity with MC1R, then MC4R, MC3R, MC5R, and MC2R receptors. As MC4R receptors are present on neurons in the central nervous...
36 KB (3,872 words) - 15:23, 22 August 2024
include Prader-Willi syndrome and mutations of LEP (leptin gene), LEPR, POMC, MC4R, and CART. It can also result from injuries to the hypothalamus either from...
2 KB (218 words) - 00:02, 30 July 2024
melanocyte-stimulating hormone (MSH) at the melanocortin receptor (MC4R), as MC4R is responsible for regulating food intake by inhibiting appetite signals...
27 KB (3,257 words) - 21:56, 17 August 2024
associated with or responsible for obesity. These include genes such as MC4R, LEP, LEPR, and FTO. One of the lesser known gene diseases that is known...
24 KB (2,718 words) - 10:56, 11 April 2024
S1PR3 S1PR5 S1PR2 GPR6 GPR12 S1PR4 LPAR3 LPAR2 GPR3 MC3R MC5R MC2R MC1R MC4R GPR119 Discovery and development of Cannabinoid Receptor 1 Antagonists Cannabinoid...
40 KB (4,148 words) - 01:52, 18 September 2024
wide range of processes including the regulation of body weight (MC3R and MC4R), adrenal steroidogenesis (MC2R) and hair pigmentation (MC1R). Published...
23 KB (2,900 words) - 08:39, 17 August 2024
HGNC:6929 Q01726 9332 MC2R HGNC:6930 Q01718 9333 MC3R HGNC:6931 P41968 9334 MC4R HGNC:6932 P32245 9335 MC5R HGNC:6933 P33032 9336 MCAM HGNC:6934 P43121 9337...
277 KB (17 words) - 18:41, 6 October 2024
biological targets of leptin action, such as the Melanocortin 4 receptor (MC4R). Her group have also demonstrated that the central leptin-melanocortin axis...
15 KB (1,303 words) - 08:12, 8 November 2023
Source: CNR1 GPR12 GPR6 S1PR1 S1PR4 S1PR3 S1PR5 S1PR2 LPAR1 GPR3 LPAR3 LPAR2 MC4R MC5R GPR119 MC1R MC3R MC2R GRCh38: Ensembl release 89: ENSG00000188822 –...
36 KB (3,887 words) - 16:09, 22 September 2024
receptor (MC1R, MSHR) Melanocortin 3 receptor (MC3R) Melanocortin 4 receptor (MC4R) Melanocortin 5 receptor (MC5R) ACTH receptor (MC2R), ACTR) GPR3 (GPR3) GPR6...
25 KB (2,172 words) - 01:01, 29 November 2023
color in Europeans and East Asians is an example of convergent evolution. MC4R MC3R MC5R MC2R GPR6 GPR12 S1PR2 GPR3 S1PR1 LPAR1 CNR1 LPAR2 GPR119 S1PR3...
33 KB (3,769 words) - 04:57, 6 May 2024
α-MSH-induced secretion of corticosterone. Orthologs of AgRP, ASIP, MCIR, and MC4R have been found in mammalian, teleost fish, and avian genomes. This suggests...
24 KB (2,767 words) - 05:59, 16 July 2024
2006). "Understanding how a weight loss drug works: serotonin linked to MC4R". Foundation for Prader-Willi Research. Zhou, L; Williams, T; Lachey, JL;...
17 KB (1,982 words) - 04:04, 25 September 2024
proopiomelanocortin deficiency 609734 2p23.3 melanocortin-4 receptor polymorphism (MC4R) 155541 18q22 BMIQ1 7q32.3 near D7S1804 BMIQ2 13q14 near D13S257 BMIQ3 6q23-q25...
25 KB (2,298 words) - 20:34, 9 March 2024
PMID 21725307. Siljee, Jacqueline (Feb 2018). "Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic...
9 KB (947 words) - 20:42, 16 September 2024
S; Dermitzakis, E. T.; Doney, A. S.; et al. (2008). "Common variants near MC4R are associated with fat mass, weight and risk of obesity". Nature Genetics...
20 KB (1,623 words) - 08:46, 4 October 2024
Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2023-12-16. "MC4R melanocortin 4 receptor [Homo sapiens (Human)] - Gene - NCBI". "BSCL2 BSCL2...
20 KB (1,140 words) - 07:01, 12 February 2024
IGF2BP2, SLC30A8, JAZF1, HHEX, DGKB, CDKN2A, CDKN2B, KCNQ1, HNF1A, HNF1B MC4R, GIPR, HNF4A, MTNR1B, PPARG, ZBED3, SLC30A8, CDKAL1, GLIS3, GCK, GCKR, among...
19 KB (2,339 words) - 07:33, 22 June 2024
lesions progression. LPAR2 LPAR3 S1PR1 S1PR3 S1PR5 S1PR4 S1PR2 CNR1 MC3R MC5R MC4R GPR12 MC2R GPR6 CNR2 GPR3 MC1R GPR119 Lysophospholipid receptor GRCm38: Ensembl...
10 KB (1,139 words) - 21:17, 6 April 2024
unaffected patients. S1PR3 S1PR5 S1PR2 S1PR4 LPAR1 LPAR2 LPAR3 CNR1 GPR6 GPR12 MC4R MC5R CNR2 MC3R GPR3 MC2R MC1R GPR119 S1PR1 has been shown to interact with...
21 KB (2,449 words) - 19:21, 2 June 2024
monitor weight disorders, and the administration of melanocortin 4 receptor (MC4R) agonists to certain patients, an approach currently undergoing phase 3 trials...
14 KB (1,583 words) - 07:51, 13 December 2023