is encoded by the MRGPRX2 gene. It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes. Activation of MRGPRX2 on mast cells leads...
3 KB (356 words) - 17:16, 21 June 2024
Mast cell (section MRGPRX2 mast cell receptor)
receptor MRGPRX2 plays a key role in the recognition of pathogen associated molecular patterns (PAMPs) and initiating an antibacterial response. MRGPRX2 is...
49 KB (5,615 words) - 06:31, 19 September 2024
of mast cell receptor Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2). MRGPRX2 is a G protein-coupled receptor capable of recognizing both endogenous...
15 KB (1,411 words) - 09:18, 22 August 2024
widespread. Binding to the Mas-related G protein–coupled receptor-X2 (MRGPRX2) in cutaneous mast cell is the only proven mechanism of direct mast cell...
17 KB (2,248 words) - 16:49, 16 September 2024
the use of small novel MRGPRX2 antagonists as some cases of allergies are refractive to currently available treatments. MRGPRX2 receptors are discovered...
25 KB (2,440 words) - 12:56, 9 September 2024
mast cells. This reaction is caused by the interaction of vancomycin with MRGPRX2, a GPCR-mediating IgE-independent mast cell degranulation. Less frequently...
81 KB (8,064 words) - 08:28, 19 October 2024
Q96AM1 9781 MRGPRG HGNC:24829 Q86SM5 9782 MRGPRX1 HGNC:17962 Q96LB2 9783 MRGPRX2 HGNC:17983 Q96LB1 9784 MRGPRX3 HGNC:17980 Q96LB0 9785 MRGPRX4 HGNC:17617...
277 KB (17 words) - 18:41, 6 October 2024
expanded to human skin-derived mast cells and the G protein-coupled receptors MRGPRX2 and C5aR, in addition to the ITAM-bearing FcεRI. Antibody ligation of Siglec-6...
16 KB (2,036 words) - 16:04, 7 April 2024