The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast)...

imaging technique Median raphe nucleus, area within the brain MRN complex, a protein complex involved in DNA repair Foothills Regional Airport, IATA airport...

repair pathway, the MRN complex (which consists of Mre11, Rad50 and NBS1) is attracted to the broken DNA ends and other MRN complexes to keep the broken...

and consists of an α-helix. A complex of the three proteins MRE11, RAD50 and NBS1 (XRS2 in yeast), called the MRN complex in humans, recruits ATM to double...

NBS1/hMre11/RAD50(N/M/R, more commonly referred to as MRN) double strand DNA break repair complex. This complex recognizes DNA damage and rapidly relocates to...

mutants defective in Ppmre11 or Pprad50 (that encode key proteins of the MRN complex, the principal sensor of DNA double-strand breaks) showed that these...

interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage". EMBO Rep. 9 (8): 795–801. doi:10.1038/embor...

DNA contributes to its ability to inhibit the nuclease activity of the MRN complex as well as the nuclease activity of Mre11 alone. This may explain a role...

strand breaks. The MRN complex (composed of Mre11, Rad50, and Nbs1) form immediately at the site of double strand break. This MRN complex recruits ATM to...

another MRN complex, the MDC1 protein can sense the DNA damage by binding to the γH2AX flag through its BRCT domain and brings the bound MRN complex to the...

exist in the cell as a complex, along with a third protein expressed by the hRad50 gene. This complex, known as the MRN complex, plays an important role...

first several steps. After a double-strand break occurs, the MRX complex (MRN complex in humans) binds to DNA on either side of the break. Next a resection...

a budding yeast homolog of the mammalian Mre11-Rad50-Nbs1 (MRN) DNA damage repair complex. Cells are able to accurately repair DNA double-strand breaks...

assemble on the extensive γH2AX-modified chromatin are the MRN complex (a protein complex consisting of Mre11, Rad50 and Nbs1), RAD51 and the ATM kinase...

break repair. This protein forms a complex with MRE11 and NBS1 (also known as Xrs2 in yeast). This MRN complex (MRX complex in yeast) binds to broken DNA ends...

two known substrates for this ubiquitin ligases; p53 and the MRN complex. The MRN complex, if not bound by the E1B-55K/E4orf6 ubiquitin ligase, will treat...

where this complex is called the MRX complex). Before resection can start, CtBP1-interacting protein (CtIP) needs to bind to the MRN complex so that the...

integrity. Genes Ppmre11 and Pprad50 of P. patens encode components of the MRN complex, the principal sensor of DNA double-strand breaks. These genes are necessary...

double-strand breaks (DSBs). TRRAP associates with the MRN complex and when TRRAP is removed, the complex shows reduced cDNA end-joining activity. Hence, TRRAP...

the protein mutated in AT, ATM, interacts with the MRE11/RAD50/NBS1 (MRN) complex. Other syndromes with clinical features similar to Nijmegen Breakage...

which is a mutation in the damage response kinase ATM – and BRCA1 or MRN complex mutations that play a role in responding to DNA damage. When the above...

that provide a platform to recruit proteins involved in HRR repair. The MRN complex, consisting of Mre11, Rad50 and NBS1, carries out the initial steps of...

kinase found in colorectal cancer. WDCP has also been identified in the MRN complex, which processes double-stranded breaks in DNA. WDCP is located in chromosome...

race for MRN when the field races thru the tri-oval. Dave Moody will call the action from turn 1, Mike Bagley will call the action for MRN when the field...

the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates...

which relies on DMC1, fails. MCM8 forms a complex with MCM9 that is required for DNA resection by the MRN complex (MRE11-RAD50-NBS1) at double strand breaks...

doi:10.1016/j.quascirev.2023.108162. "Lexique du substrat rocheux". dnr-mrn.gnb.ca. Retrieved 22 December 2019. "A mid-Darriwilian super volcano in northern...

the race for MRN when the field races thru the tri-oval. Dave Moody called the action from turn 1, Mike Bagley called the action for MRN when the field...

Larry McReynolds provided insight from the Fox Sports studio in Charlotte. MRN had the radio call for the race which was also simulcasted on Sirius XM NASCAR...

adjacent promoter. For AAV, the hairpins can bind to MRE11/Rad50/NBS1 (MRN) complexes and Ku70/80 heterodimers, which are involved in sensing and repairing...