In organic chemistry, the Mannich reaction is a three-component organic reaction that involves the amino alkylation of an acidic proton next to a carbonyl...

The ketimine Mannich reaction is an asymmetric synthetic technique using differences in starting material to push a Mannich reaction to create an enantiomeric...

The nitro-Mannich reaction (or aza-Henry reaction) is the nucleophilic addition of a nitroalkane (or the corresponding nitronate anion) to an imine, resulting...

A Mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde (or an aldehyde) and a carbon acid. The Mannich base is...

subsequent improvements exceeded 90%. This reaction is described as an intramolecular "double Mannich reaction" for obvious reasons. It is not unique in...

with a Mannich cyclization, and is the subject of much of this article. This tandem aza-Cope/Mannich reaction is characterized by its mild reaction conditions...

The Petasis reaction (alternatively called the Petasis borono–Mannich (PBM) reaction) is the multi-component reaction of an amine, a carbonyl, and a vinyl-...

and also Digitalis-glycosides. The Mannich reaction was named after his discovery of the mechanism in 1912. Mannich attended high school in Weimar and...

considered a special case of the Mannich reaction, which follows a similar reaction pathway. The driving force for this reaction is the electrophilicity of...

nucleophilic addition to the ion formed by the reaction of the amine and the carbonyl. The Mannich reaction can proceed both intermolecularly and intramolecularly:...

Imines synthesized in this fashion have been shown to undergo a one-pot Mannich reaction with 1,3-dicarbonyl compounds, such as malonate esters and 1,3-diketones...

olefination Kabachnik–Fields reaction Kharasch–Sosnovsky reaction Keck asymmetric allylation Ketimine Mannich reaction Ketone halogenation Kiliani–Fischer...

Kabachnik–Fields reaction Mannich reaction Passerini reaction Pauson–Khand reaction Petasis reaction Strecker amino acid synthesis Ugi reaction Asinger reaction A3...

α-aminobenzylphenols. The Betti reaction is a special case of the Mannich reaction. The reaction is named after the Italian chemist Mario Betti (1857-1942)....

alkene via a Wittig reaction, allowing for the key tertiary nitrogen and the pentacyclic core to be formed via an aza-Cope-Mannich reaction. Giorgio Ortar...

efficient synthesis of allylic amines with a modified Mannich reaction. In this modified Mannich reaction, they have found that vinyl boronic acids can participate...

dimerization of monomeric indole bases, in the following reactions: Mannich reaction (voacamine) Michael reaction (villalstonine) Condensation of aldehydes with...

methods such as the Mannich reaction and Petasis reaction. A classic named reaction is the Mignonac reaction (1921) involving reaction of a ketone with ammonia...

development of related reactions including the Michael addition, asymmetric aldol reaction, and the Mannich reaction. This reaction has likewise been used...

the Mannich-type condensation, while subsequent one-step addition of zinc iodide catalyzes the imino-retro-ene reaction. Mannich reaction Ene reaction Coupling...

attack. Gramine, a useful synthetic intermediate, is produced via a Mannich reaction of indole with dimethylamine and formaldehyde. It is the precursor...

using acetophenone, formaldehyde, and an amine hydrochloride in a Mannich reaction. It can be polymerized to poly(phenylvinyl ketone) via radical or anionic...

number of ways including reaction with ammonia or another amine such as an alkylation, reductive amination and the Mannich reaction. Many alkyl amines are...

"Hydrogen-mediated carbon-carbon bond formations: Applied to reductive aldol and Mannich reactions," Ph.D. dissertation, University of Texas (Austin), pp. 4 and 51....

to the N-methyl-Δ1-pyrrolinium cation. The first addition is a Mannich-like reaction with the enolate anion from acetyl-CoA acting as a nucleophile towards...

stable. They are invoked but rarely observed as intermediates in the Mannich reaction. These N,N',N''-trisubstituted hexahydro-1,3,5-triazines arise from...

substitution but will also become part of the strychnine skeleton. A Mannich reaction with formaldehyde and dimethylamine) produced gramine 4. Alkylation...

and naftifine; the latter spurred the development of Petasis' borono-Mannich reaction. Flunarizine aids in the relief of migraines while naftifine acts to...

(July 1977). "2-Methyl-3-butyn-2-ol as an acetylene precursor in the Mannich reaction. A new synthesis of suicide inactivators of monoamine oxidase". The...

rearrangement Duff reaction Mannich reaction Pictet-Spengler reaction Stephen aldehyde synthesis Stork enamine alkylation Vilsmeier-Haack reaction and Vilsmeier...