• Thumbnail for Myostatin
    Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. Myostatin is a myokine...
    48 KB (5,322 words) - 21:51, 13 July 2024
  • Myostatin inhibitors are a class of drugs that work by blocking the effects of myostatin, which inhibits muscle growth. In animal models and limited human...
    11 KB (1,195 words) - 00:18, 21 June 2024
  • Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. Affected individuals...
    7 KB (708 words) - 06:35, 16 November 2023
  • Thumbnail for Belgian Blue
    natural mutation in the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). Myostatin is a protein that...
    11 KB (1,224 words) - 03:41, 4 July 2024
  • Thumbnail for Sarcopenic obesity
    injury/inflammation in response to stress) are increased in sarcopenic obesity. Myostatin is also increased. In the fat, lipotoxicity and chronic inflammation are...
    30 KB (3,718 words) - 05:33, 12 August 2024
  • known mutations that limits and reduces the activity of the myostatin protein. Normally, myostatin limits the number of muscle fibers present at birth, and...
    6 KB (823 words) - 13:50, 28 March 2024
  • Myokine (section Myostatin)
    the term myokine first occurred in 2003. In 2008, the first myokine, myostatin, was identified. The gp130 receptor cytokine IL-6 (Interleukin 6) was...
    36 KB (4,573 words) - 00:48, 7 July 2024
  • Thumbnail for Limousin cattle
    identified a natural variant of the myostatin gene found in Limousins which has a significant influence on them. The myostatin gene is found in all mammals and...
    86 KB (10,454 words) - 13:47, 10 January 2024
  • Thumbnail for Piedmontese cattle
    Piedmontese cattle carry a unique gene mutation identified as an inactive myostatin allele that causes hypertrophic muscle growth, or double muscling. Purebred...
    8 KB (734 words) - 17:37, 30 December 2023
  • Thumbnail for YK-11
    PMID 23995658. Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (March 2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis"...
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  • amount of myostatin portray deficiency in muscle development and increase of fat; on the other hand, smaller than normal amounts of myostatin greatly increase...
    4 KB (383 words) - 20:49, 14 January 2024
  • Stamulumab (category Myostatin inhibitors)
    Stamulumab (MYO-029) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy (MD). Stamulumab...
    6 KB (524 words) - 13:17, 19 August 2024
  • Thumbnail for Follistatin
    Follistatin (category Myostatin inhibitors)
    its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive...
    19 KB (2,169 words) - 07:41, 4 August 2024
  • Thumbnail for North American Piedmontese
    naturally occurring gene identified as the myostatin allele mutation, or inactive myostatin gene. Myostatin prohibits muscle growth whereas an inactive...
    17 KB (1,804 words) - 04:55, 10 June 2023
  • Thumbnail for Gene doping
    small interfering RNA. Myostatin is a protein responsible for inhibiting muscle differentiation and growth. Removing the myostatin gene or otherwise limiting...
    32 KB (3,911 words) - 14:38, 6 June 2024
  • Thumbnail for Whippet
    second leading cause of mortality in Whippets. A 2007 study identified a myostatin mutation particular to Whippets that is significantly associated with...
    26 KB (2,680 words) - 01:27, 20 August 2024
  • Thumbnail for Exercise mimetic
    ; McPherron, Alexandra C. (October 2011). "Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation". Medicine and Science in...
    4 KB (392 words) - 18:19, 10 August 2024
  • receptors regulate muscle growth. Myostatin, a TGF-beta superfamily member, is a negative regulator of muscle growth. Myostatin binds to ACVR2B and to a lesser...
    6 KB (583 words) - 15:40, 29 March 2023
  • Apitegromab (category Myostatin inhibitors)
    precursor to myostatin, which limits the size of skeletal muscle tissue, as well as inactive myostatin. It does not bind to active myostatin, activin A...
    5 KB (259 words) - 10:47, 12 November 2023
  • Thumbnail for GDF11
    to myostatin, a negative regulator of muscle growth, both structurally and phylogenetically. Though GDF11 is 90% structurally similar to myostatin, GDF11's...
    34 KB (3,979 words) - 20:36, 23 June 2024
  • Thumbnail for Transforming growth factor beta
    (Drm) LTBP1 Noggin TGIF Thrombospondin 1 (THBS1) Tomoregulin 1 Antibodies: Stamulumab (against myostatin) TRC105 (against endoglin) Others: Endoglin...
    70 KB (8,486 words) - 02:10, 19 August 2024
  • Thumbnail for Spinal muscular atrophy
    monoclonal antibody that blocks the activation of the skeletal muscle protein myostatin, thereby promoting muscle tissue growth. As of 2021, the molecule showed...
    89 KB (9,953 words) - 10:33, 25 May 2024
  • Thumbnail for Decoy receptors
    binds to myostatin, it lowers the amount of myostatin that can bind to the native receptor in the membrane (ActRIIB), preventing myostatin from delivering...
    6 KB (686 words) - 02:37, 26 February 2022
  • the use of superhuman strength in fiction. Berserker Furor Teutonicus Myostatin Physical strength Hysterical strength Kumar, Rajesh (2010-09-01). "Competing...
    10 KB (1,029 words) - 06:44, 17 July 2024
  • Thumbnail for Texel sheep
    total carcass fat—especially seam fat. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206...
    10 KB (1,058 words) - 18:13, 13 September 2023
  • Thumbnail for GDF15
    (Drm) LTBP1 Noggin TGIF Thrombospondin 1 (THBS1) Tomoregulin 1 Antibodies: Stamulumab (against myostatin) TRC105 (against endoglin) Others: Endoglin...
    13 KB (1,339 words) - 17:49, 3 August 2024
  • may refer to: Kocher–Debré–Semelaigne syndrome Adrenogenital syndrome Myostatin mutation resulting in hypertrophy and increased strength This disambiguation...
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  • and Mighty Mouse Mighty mice, a genetic strain of house mouse with the myostatin gene knocked out Mighty Mouse, the first mouse with a scroll wheel jointly...
    947 bytes (158 words) - 20:23, 28 October 2022
  • Thumbnail for Meat
    its side effects can be counteracted by the administration of hormones. Myostatin has been used to produce muscle hypertrophy. Sedatives may be administered...
    115 KB (10,576 words) - 06:17, 4 August 2024
  • Eddie Hall (category People with Myostatin-related muscle hypertrophy)
    Edward Stephen Hall (born 15 January 1988) is a British media personality and retired strongman. He is best known for his world-record setting 500 kg (1...
    33 KB (2,843 words) - 14:36, 16 August 2024