Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene. NEK2 has been shown to interact with MAPK1 and NDC80. Protein...
9 KB (1,182 words) - 11:51, 2 November 2024
Hec1/Nek2 mitotic pathway inhibitor I. INH1 controls the biological activity of Hec1/Nek2 mitotic pathway. It specifically disrupts the Hec1/Nek2 interaction...
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Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2". J Cell Biol. 141 (7): 1563–1574. doi:10.1083/jcb.141.7.1563. PMC 2133000...
24 KB (2,611 words) - 13:50, 13 September 2024
of chromosomes is achieved. NDC80 has been shown to interact with MIS12, NEK2 and PSMC2. GRCh38: Ensembl release 89: ENSG00000080986 – Ensembl, May 2017...
10 KB (1,178 words) - 15:32, 6 April 2024
position 415-421 aa. Ser/Thr residues are phosphorylated by the kinase. Two NEK2 phosphorylation sites at positions 415-420 bp and 423-428 aa. Table 1. Results...
46 KB (3,998 words) - 06:32, 20 September 2024
(2004). "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi". Exp. Cell Res. 292 (2): 393–402. doi:10.1016/j...
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HGNC:18956 Q969S2 10428 NEIL3 HGNC:24573 Q8TAT5 10429 NEK1 HGNC:7744 Q96PY6 10430 NEK2 HGNC:7745 P51955 10431 NEK3 HGNC:7746 P51956 10432 NEK4 HGNC:11399 P51957...
282 KB (17 words) - 18:42, 6 October 2024
include constituents of the ROD-ZW10 complex, p31comet, MAPK, CDK1-cyclin-B, NEK2, and PLK1. The SAC monitors the interaction between improperly connected...
73 KB (9,145 words) - 07:11, 31 August 2024
PMID 10827081. Helps NR, Luo X, Barker HM, Cohen PT (2001). "NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed...
15 KB (1,805 words) - 22:47, 2 October 2024
MUSK ; MYLK ; MYLK2 ; MYLK3 ; MYLK4 ; MYO3A ; MYO3B ; NEK1 ; NEK10 ; NEK11 ; NEK2 ; NEK3 ; NEK4 ; NEK5 ; NEK6 ; NEK7 ; NEK8 ; NEK9 ; NIM1K ; NLK ; NPR1 ; NPR2 ;...
17 KB (1,566 words) - 18:56, 22 September 2024
Casein kinase 1 (CK1) site, three Casein kinase 2 (CK2) sites, and three NEK2 sites. The exact structure of the MIPOL1 has not yet been characterized....
23 KB (1,969 words) - 08:44, 10 March 2024
Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2". J Cell Biol. 141 (7): 1563–74. doi:10.1083/jcb.141.7.1563. PMC 2133000...
6 KB (701 words) - 23:02, 25 March 2024
DUSP1, DUSP3, ELK1, FHL2, HDAC4, MAP2K1, MAP3K1 MAPK14, MKNK1, MKNK2, Myc, NEK2, PEA15, PTPN7, Phosphatidylethanolamine binding protein 1, RPS6KA1, RPS6KA2...
20 KB (2,283 words) - 00:38, 15 June 2024
Merdes A, Hayes MJ, Faragher AJ, Fry AM (April 2005). "Dynamic Recruitment of Nek2 Kinase to the Centrosome Involves Microtubules, PCM-1, and Localized Proteasomal...
17 KB (1,718 words) - 06:36, 27 May 2024
Rootletin physically interacts with. Furthermore, Rootletin is phosphorylated by Nek2 kinase. GRCh38: Ensembl release 89: ENSG00000058453 – Ensembl, May 2017 GRCm38:...
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expression of a large array of G2/M-specific genes, such as Plk1, cyclin B2, Nek2 and CENPF, and plays an important role in maintenance of chromosomal segregation...
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ALS Association providing funding raised through the Ice Bucket Challenge. NEK2 NEK3 NEK4 GRCh38: Ensembl release 89: ENSG00000137601 – Ensembl, May 2017...
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the former, it has been suggested that Aurora A cooperates with the kinase Nek2 in Xenopus to dissolve the structure tethering the cell's centrosomes together...
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2007). "Protein phosphatase-1alpha regulates centrosome splitting through Nek2". Cancer Research. 67 (3): 1082–9. doi:10.1158/0008-5472.CAN-06-3071. PMID 17283141...
31 KB (3,092 words) - 01:49, 10 March 2024
adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nature Cell Biology. 7 (10): 937–46. doi:10.1038/ncb1309...
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et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization". J. Cell Sci. 120 (Pt...
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Sutterlin C, Ried T, Nigg EA (Oct 1994). "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus...
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adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nat. Cell Biol. 7 (10): 937–46. doi:10.1038/ncb1309...
64 KB (8,012 words) - 11:54, 5 January 2024