NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. Oxygen sensing is essential...
10 KB (1,223 words) - 00:36, 4 March 2023
isoforms of the catalytic component of the complex include NOX1, NOX2, NOX3, NOX4, NOX5, DUOX1, and DUOX2. NADPH oxidase catalyzes the production of a superoxide...
25 KB (2,841 words) - 14:26, 5 March 2024
experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1. Setanaxib is a member of the pyrazolopyridine dione chemical series...
15 KB (1,787 words) - 05:14, 27 September 2023
"Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2". American Journal of Physiology. Cell Physiology. 296 (4):...
7 KB (692 words) - 09:38, 19 May 2024
susceptibility in Japanese populations, which were HS6ST3A1/B1, KIAA0825, and NOX4. However, the linkage disequilibrium is low to moderate suggesting that linkage...
13 KB (1,514 words) - 03:07, 12 February 2024
intracrine manner, LTC4 then elicits nuclear translocation of NADPH oxidase 4 (NOX4), ROS accumulation and oxidative DNA damage. Besides being a potent lipid...
7 KB (563 words) - 02:22, 11 November 2023
HGNC:7887 Q9UNW9 10700 NOX1 HGNC:7889 Q9Y5S8 10701 NOX3 HGNC:7890 Q9HBY0 10702 NOX4 HGNC:7891 Q9NPH5 10703 NOX5 HGNC:14874 Q96PH1 10704 NOXA1 HGNC:10668 Q86UR1...
282 KB (17 words) - 07:55, 20 June 2024
"Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy". American Journal of Nephrology...
19 KB (2,367 words) - 02:26, 16 July 2024
molecular mass of 22.0 kDa. It associates with NOX2 and with NOX1, NOX3 and NOX4 in a 1:1 complex and has a ubiquitous expression. The main physiological...
37 KB (4,853 words) - 00:44, 28 March 2024
et al. (November 2013). "Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury". Journal of Molecular and Cellular...
20 KB (2,434 words) - 00:26, 3 December 2023
J (February 2013). "Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy". Circulation Research...
25 KB (2,845 words) - 00:21, 10 March 2024
identified animal coronaviruses with pandemic potential. Researchers report that NOX4 facilitates certain beneficial adaptive responses to exercise mediated by...
299 KB (39,014 words) - 13:11, 31 July 2024
(May 2001). "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5". Gene. 269 (1–2): 131–40. doi:10.1016/S0378-1119(01)00449-8. PMID 11376945...
5 KB (579 words) - 22:24, 6 April 2024
has seven members including NOX1, NOX2 (formerly known as gp91phox), NOX3, NOX4, NOX5, DUOX1 and DUOX2. This protein is known as a dual oxidase because it...
16 KB (1,901 words) - 19:21, 27 March 2024
et al. (2001). "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5". Gene. 269 (1–2): 131–40. doi:10.1016/S0378-1119(01)00449-8. PMID 11376945...
7 KB (927 words) - 02:03, 4 March 2023
Quinn MT, et al. (2004). "Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 24 (4):...
7 KB (883 words) - 22:57, 4 September 2022
has seven members including NOX1, NOX2 (formerly known as gp91phox), NOX3, NOX4, NOX5, DUOX1 (this enzyme) and DUOX2. The current model for ROS generation...
17 KB (2,137 words) - 19:23, 27 March 2024
PWR-1E cell apoptosis. The effect appears due to the loss of BLT2-induced NOX4 generation, consequential reactive oxygen species-induced NF-κB-activation...
50 KB (6,792 words) - 02:25, 22 June 2024