Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. Neurexins are a family of proteins that function in the vertebrate nervous...
11 KB (1,321 words) - 15:55, 7 July 2023
several genes that have been linked to individual linguistic ability. The NRXN1 gene has been linked to general language ability, and mutations of this...
18 KB (2,050 words) - 07:04, 26 August 2024
schizophrenia. In mammals, neurexin is encoded by three different genes (NRXN1, NRXN2, and NRXN3) each controlled by two different promoters, an upstream...
28 KB (2,859 words) - 09:27, 10 June 2024
(FAT1, FAT2, FAT3, FAT4), NEL-like proteins (NELL1, NELL2), neurexins (NRXN1, NRXN2, NRXN3), slit homologs (SLIT1, SLIT2, SLIT3), thrombospondins (THBS1...
31 KB (3,371 words) - 18:35, 28 September 2024
gene on the long arm of chromosome 7 (7q33-q36) and the neurexin 1 alpha (NRXN1) gene on the short arm of chromosome 2 (2p16.3). Malformations in the CNS...
18 KB (1,866 words) - 06:07, 22 September 2024
Mutation in the MET gene demonstrably raises risk of autism by 2.27 times. NRXN1 2q32 In February 2007, researchers in the Autism Genome Project (an international...
113 KB (10,805 words) - 00:35, 5 August 2024
Q8IZ57 10832 NRSN2 HGNC:16229 Q9GZP1 10833 NRTN HGNC:8007 Q99748 10834 NRXN1 HGNC:8008 P58400 Q9ULB1 10835 NRXN2 HGNC:8009 P58401 Q9P2S2 10836 NRXN3...
282 KB (17 words) - 18:42, 6 October 2024
SCN2A) ASD-associated CNVs (e.g.: 16p11.2 deletion/duplication, exonic NRXN1 deletions) Currently undefined.[clarification needed] Causes of autism Conditions...
17 KB (1,194 words) - 17:38, 1 October 2024
schizophrenia and deletions at 1q21.1, 3q29, 15q13.3, 22q11.21 en Neurexin 1 (NRXN1) and duplications at 16p11.2 are at 7.5% or higher. Common variations in...
21 KB (2,031 words) - 03:52, 15 July 2024
"Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1". BMC Med Genet. 12: 106. doi:10.1186/1471-2350-12-106. PMC 3162517. PMID 21827697...
14 KB (1,570 words) - 11:17, 29 December 2023
examined CNVs in neurexins, and found that exon-affecting deletions in the NRXN1 gene conferred risk of schizophrenia. An updated meta-analysis on CNVs for...
130 KB (14,925 words) - 19:02, 29 September 2024
several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters...
7 KB (766 words) - 00:36, 4 March 2023
schizophrenia and deletions at 1q21.1, 3q29, 15q13.3, 22q11.21 en Neurexin 1 (NRXN1) and duplications at 16p11.2 are at 7.5% or higher. Common variations in...
21 KB (2,208 words) - 12:57, 24 September 2024
several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters...
8 KB (1,125 words) - 00:27, 3 December 2023
nervous system synapses. NLGN1 has been shown to interact with NRXN1 and DLG4. Neurexins: NRXN1, NRXN2, NRXN3 GRCh38: Ensembl release 89: ENSG00000169760 –...
7 KB (887 words) - 22:18, 3 March 2023
Orrico A, Ousager LB, Collins AL, et al. (November 2009). "CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation...
12 KB (1,398 words) - 20:19, 21 January 2024
(NRXN1). Neurexins are cell adhesion molecules and often contain EGF binding domains, enhancing intracellular junction forming between cells. NRXN1 is...
20 KB (2,400 words) - 03:09, 30 March 2024
candidate genes relating to ASD in mice exposed to valproate in utero are NRXN1, NRXN2, NRXN3, NLGN1, NLGN2, and NLGN3. In the somatosensory cortex, CA1...
52 KB (6,263 words) - 12:20, 11 October 2024
NID2; NOTCH1; NOTCH2; NOTCH2NL; NOTCH3; NOTCH4; NRG1; NRG2; NRG3; NRG4; NRXN1; NRXN2; NRXN3; NTNG2; ODZ1; ODZ2; OIT3; PLAT; PP187; PROC; PROS1; PROZ;...
25 KB (3,071 words) - 16:22, 5 September 2024
chromosomal regions with large amounts of CNVs. A CNV located at the gene NRXN1, which encodes a neurexin protein involved in synaptic transmission, is...
44 KB (5,482 words) - 19:47, 29 June 2024