Exo-α-sialidase (EC 3.2.1.18, sialidase, neuraminidase; systematic name acetylneuraminyl hydrolase) is a glycoside hydrolase that cleaves the glycosidic...
16 KB (1,568 words) - 17:03, 31 May 2024
Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are a commonly used antiviral drug type against influenza...
10 KB (1,048 words) - 22:22, 8 November 2023
Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. Neuraminidases...
11 KB (1,059 words) - 09:11, 30 January 2024
Oseltamivir (category Neuraminidase inhibitors)
Oseltamivir was approved for medical use in the US in 1999. It was the first neuraminidase inhibitor available by mouth. It is on the World Health Organization's...
63 KB (5,827 words) - 04:34, 19 December 2024
Zanamivir (category Neuraminidase inhibitors)
prevent influenza caused by influenza A and influenza B viruses. It is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings...
19 KB (1,929 words) - 13:03, 22 July 2024
Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast...
4 KB (366 words) - 21:21, 6 August 2023
IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. Almost all possible combinations of H (1 through 16) and...
60 KB (6,050 words) - 22:43, 7 January 2025
major glycoprotein (HA) spike is interposed irregularly by clusters of neuraminidase (NA) spikes, with a ratio of HA to NA of about 10 to 1. The viral envelope...
39 KB (4,238 words) - 21:59, 1 December 2024
Neuraminidase inhibitors inhibit enzymatic activity of the enzyme neuraminidase (sialidase). These type of inhibitors have been introduced as anti-influenza...
30 KB (4,066 words) - 17:50, 28 January 2023
Sialidosis (redirect from Alpha-neuraminidase deficiency)
disease that results from a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase). The lack of this enzyme results in an abnormal accumulation...
5 KB (547 words) - 17:37, 6 November 2024
Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its...
2 KB (97 words) - 02:46, 1 May 2024
Mumps virus (redirect from Mumps hemagglutinin-neuraminidase)
protein, small hydrophobic (SH) transmembrane protein, hemagglutinin-neuraminidase (HN), and the large (L) protein, which combines with the P protein to...
21 KB (2,850 words) - 11:40, 17 December 2024
have human susceptibility. It is the variation in hemagglutinin (and neuraminidase) subtypes that require health organizations (ex. WHO) to constantly...
19 KB (2,098 words) - 23:29, 11 December 2024
Galactosialidosis (redirect from Neuraminidase beta-galactosidase deficiency)
Galactosialidosis, also known as neuraminidase deficiency with beta-galactosidase deficiency, is a genetic lysosomal storage disease. It is caused by...
15 KB (1,712 words) - 18:41, 11 December 2024
two proteins on the surface of the viral envelope; hemagglutinin and neuraminidase. These are the major antigens of the virus against which neutralizing...
64 KB (7,173 words) - 14:34, 6 January 2025
(NP), phosphoprotein (P) and the large protein (L). The hemagglutinin–neuraminidase (HN) is involved with viral attachment and thus hemadsorption and hemagglutination...
30 KB (3,085 words) - 19:29, 4 December 2024
IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. All subtypes of IAV share a negative-sense, segmented RNA...
16 KB (1,651 words) - 20:44, 20 August 2024
Parainfluenza hemagglutinin-neuraminidase is a type of hemagglutinin-neuraminidase produced by parainfluenza. Murrell M, Porotto M, Weber T, Greengard...
1 KB (109 words) - 18:10, 29 April 2022
IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. All subtypes of IAV share a negative-sense, segmented RNA...
53 KB (5,252 words) - 12:24, 27 December 2024
filamentous. Its 500 or so surface projections are made of hemagglutinin and neuraminidase. The influenza B virus genome is 14,548 nucleotides long and consists...
28 KB (3,098 words) - 20:27, 19 December 2024
combination of the antigenic viral proteins haemagglutinin (H) and neuraminidase (N) in the viral envelope; for example, "H1N1" designates an IAV subtype...
114 KB (13,195 words) - 02:04, 6 January 2025
and routine use for treating pneumonia is not supported by evidence. Neuraminidase inhibitors may be used to treat viral pneumonia caused by influenza...
121 KB (12,755 words) - 01:28, 22 December 2024
folate-sensitive Neural tube defects X linked Neuraminidase beta-galactosidase deficiency Neuraminidase deficiency Neurasthenia Neurilemmomatosis Neuritis...
8 KB (654 words) - 05:37, 10 November 2024
utilized by S. pneumoniae, thus increasing the likelihood of colonization. Neuraminidase also increases instances of epithelial binding through its cleavage...
15 KB (1,667 words) - 20:40, 17 July 2024
results from changes occurring in neuraminidase and hemagglutinin proteins on the viral surface. Currently, neuraminidase inhibitors (NAIs) are the most...
56 KB (6,754 words) - 01:54, 18 December 2024
during the 2008–2009 flu season. The U.S. CDC guidelines recommend only neuraminidase inhibitors for influenza treatment and prophylaxis.[medical citation...
62 KB (6,065 words) - 20:15, 5 January 2025
that of swine flu viruses present in U.S. pigs since 1999, but the neuraminidase (NA) and matrix protein (M) genes resembled versions present in European...
62 KB (6,709 words) - 07:06, 14 August 2024
Antiviral drugs Adamantane derivatives Amantadine Rimantadine Neuraminidase inhibitor Oseltamivir Laninamivir Peramivir Zanamivir Peramivir (experimental)...
70 KB (6,596 words) - 01:42, 7 January 2025
infection. The main classes of antiviral drugs used against influenza are neuraminidase inhibitors, such as zanamivir and oseltamivir, polymerase acidic endonuclease...
43 KB (4,904 words) - 20:22, 5 December 2024
serotype of IAV is determined by the HA and neuraminidase (NA) proteins expressed on its surface. Neuraminidase has 11 known subtypes; hence, influenza viruses...
27 KB (3,001 words) - 21:02, 20 October 2024