• Thumbnail for Neuraminidase
    Exo-α-sialidase (EC 3.2.1.18, sialidase, neuraminidase; systematic name acetylneuraminyl hydrolase) is a glycoside hydrolase that cleaves the glycosidic...
    16 KB (1,568 words) - 17:03, 31 May 2024
  • Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are a commonly used antiviral drug type against influenza...
    10 KB (1,048 words) - 22:22, 8 November 2023
  • Thumbnail for Viral neuraminidase
    Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. Neuraminidases...
    11 KB (1,059 words) - 09:11, 30 January 2024
  • Thumbnail for Oseltamivir
    Oseltamivir (category Neuraminidase inhibitors)
    Oseltamivir was approved for medical use in the US in 1999. It was the first neuraminidase inhibitor available by mouth. It is on the World Health Organization's...
    63 KB (5,827 words) - 04:34, 19 December 2024
  • Thumbnail for Zanamivir
    Zanamivir (category Neuraminidase inhibitors)
    prevent influenza caused by influenza A and influenza B viruses. It is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings...
    19 KB (1,929 words) - 13:03, 22 July 2024
  • Thumbnail for Hemagglutinin-neuraminidase
    Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast...
    4 KB (366 words) - 21:21, 6 August 2023
  • Thumbnail for Influenza A virus
    IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. Almost all possible combinations of H (1 through 16) and...
    60 KB (6,050 words) - 22:43, 7 January 2025
  • Thumbnail for Orthomyxoviridae
    major glycoprotein (HA) spike is interposed irregularly by clusters of neuraminidase (NA) spikes, with a ratio of HA to NA of about 10 to 1. The viral envelope...
    39 KB (4,238 words) - 21:59, 1 December 2024
  • Neuraminidase inhibitors inhibit enzymatic activity of the enzyme neuraminidase (sialidase). These type of inhibitors have been introduced as anti-influenza...
    30 KB (4,066 words) - 17:50, 28 January 2023
  • Thumbnail for Sialidosis
    disease that results from a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase). The lack of this enzyme results in an abnormal accumulation...
    5 KB (547 words) - 17:37, 6 November 2024
  • Thumbnail for Bacterial neuraminidase
    Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its...
    2 KB (97 words) - 02:46, 1 May 2024
  • Thumbnail for Mumps virus
    protein, small hydrophobic (SH) transmembrane protein, hemagglutinin-neuraminidase (HN), and the large (L) protein, which combines with the P protein to...
    21 KB (2,850 words) - 11:40, 17 December 2024
  • Thumbnail for Hemagglutinin
    have human susceptibility. It is the variation in hemagglutinin (and neuraminidase) subtypes that require health organizations (ex. WHO) to constantly...
    19 KB (2,098 words) - 23:29, 11 December 2024
  • Thumbnail for Galactosialidosis
    Galactosialidosis, also known as neuraminidase deficiency with beta-galactosidase deficiency, is a genetic lysosomal storage disease. It is caused by...
    15 KB (1,712 words) - 18:41, 11 December 2024
  • Thumbnail for Avian influenza
    two proteins on the surface of the viral envelope; hemagglutinin and neuraminidase. These are the major antigens of the virus against which neutralizing...
    64 KB (7,173 words) - 14:34, 6 January 2025
  • Thumbnail for Human parainfluenza viruses
    (NP), phosphoprotein (P) and the large protein (L). The hemagglutinin–neuraminidase (HN) is involved with viral attachment and thus hemadsorption and hemagglutination...
    30 KB (3,085 words) - 19:29, 4 December 2024
  • Thumbnail for Influenza A virus subtype H3N2
    IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. All subtypes of IAV share a negative-sense, segmented RNA...
    16 KB (1,651 words) - 20:44, 20 August 2024
  • Parainfluenza hemagglutinin-neuraminidase is a type of hemagglutinin-neuraminidase produced by parainfluenza. Murrell M, Porotto M, Weber T, Greengard...
    1 KB (109 words) - 18:10, 29 April 2022
  • Thumbnail for Influenza A virus subtype H1N1
    IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. All subtypes of IAV share a negative-sense, segmented RNA...
    53 KB (5,252 words) - 12:24, 27 December 2024
  • Thumbnail for Influenza B virus
    filamentous. Its 500 or so surface projections are made of hemagglutinin and neuraminidase. The influenza B virus genome is 14,548 nucleotides long and consists...
    28 KB (3,098 words) - 20:27, 19 December 2024
  • Thumbnail for Influenza
    combination of the antigenic viral proteins haemagglutinin (H) and neuraminidase (N) in the viral envelope; for example, "H1N1" designates an IAV subtype...
    114 KB (13,195 words) - 02:04, 6 January 2025
  • Thumbnail for Pneumonia
    and routine use for treating pneumonia is not supported by evidence. Neuraminidase inhibitors may be used to treat viral pneumonia caused by influenza...
    121 KB (12,755 words) - 01:28, 22 December 2024
  • folate-sensitive Neural tube defects X linked Neuraminidase beta-galactosidase deficiency Neuraminidase deficiency Neurasthenia Neurilemmomatosis Neuritis...
    8 KB (654 words) - 05:37, 10 November 2024
  • utilized by S. pneumoniae, thus increasing the likelihood of colonization. Neuraminidase also increases instances of epithelial binding through its cleavage...
    15 KB (1,667 words) - 20:40, 17 July 2024
  • Thumbnail for Antiviral drug
    results from changes occurring in neuraminidase and hemagglutinin proteins on the viral surface. Currently, neuraminidase inhibitors (NAIs) are the most...
    56 KB (6,754 words) - 01:54, 18 December 2024
  • Thumbnail for Amantadine
    during the 2008–2009 flu season. The U.S. CDC guidelines recommend only neuraminidase inhibitors for influenza treatment and prophylaxis.[medical citation...
    62 KB (6,065 words) - 20:15, 5 January 2025
  • Thumbnail for Pandemic H1N1/09 virus
    that of swine flu viruses present in U.S. pigs since 1999, but the neuraminidase (NA) and matrix protein (M) genes resembled versions present in European...
    62 KB (6,709 words) - 07:06, 14 August 2024
  • Thumbnail for 2020–2025 H5N1 outbreak
    Antiviral drugs Adamantane derivatives Amantadine Rimantadine Neuraminidase inhibitor Oseltamivir Laninamivir Peramivir Zanamivir Peramivir (experimental)...
    70 KB (6,596 words) - 01:42, 7 January 2025
  • Thumbnail for Treatment of influenza
    infection. The main classes of antiviral drugs used against influenza are neuraminidase inhibitors, such as zanamivir and oseltamivir, polymerase acidic endonuclease...
    43 KB (4,904 words) - 20:22, 5 December 2024
  • Thumbnail for Hemagglutinin (influenza)
    serotype of IAV is determined by the HA and neuraminidase (NA) proteins expressed on its surface. Neuraminidase has 11 known subtypes; hence, influenza viruses...
    27 KB (3,001 words) - 21:02, 20 October 2024