called P450-containing monooxygenase systems, although self-sufficient, non-monooxygenase P450s have been also described. All known P450-containing monooxygenase...
11 KB (937 words) - 05:27, 15 December 2023
enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength...
15 KB (1,669 words) - 15:00, 1 October 2024
ISBN 0-8493-2983-3. Databases Drug metabolism database Directory of P450-containing Systems University of Minnesota Biocatalysis/Biodegradation Database SPORCalc...
32 KB (3,618 words) - 16:03, 7 July 2024
Cytochrome P450 reductase (also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase...
20 KB (2,455 words) - 05:59, 2 October 2024
ISBN 0-8493-2983-3. Databases Drug metabolism database Directory of P450-containing Systems University of Minnesota Biocatalysis/Biodegradation Database Drug...
16 KB (1,932 words) - 11:58, 2 October 2024
In biochemistry, cytochrome P450 enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, and archaea, as well...
42 KB (4,497 words) - 18:55, 1 October 2024
CYP1A2 (redirect from Cytochrome P450 1A2)
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in...
30 KB (2,813 words) - 06:34, 23 September 2024
CYP3A4 (redirect from Cytochrome P450 3A4)
Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans...
80 KB (7,794 words) - 21:26, 15 July 2024
ferricytochrome b5 + H2O Cytochrome b Cytochrome b5 deficiency P450-containing systems Cytochrome b5, type A Lederer F (1994). "The cytochrome b5-fold:...
5 KB (548 words) - 23:47, 13 April 2022
This article covers protein engineering of cytochrome (CYP) P450 enzymes. P450s are involved in a range of biochemical catabolic and anabolic process....
13 KB (1,351 words) - 04:07, 27 July 2024
NADPH-cytochrome P450 reductase in the baculovirus/insect cell system". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 31 (6): 345–56...
11 KB (1,551 words) - 02:54, 2 July 2023
Flavin adenine dinucleotide (category Articles containing unverified chemical infoboxes)
heme of the P450. The P450 systems that are located in the mitochondria are dependent on two electron transfer proteins: An FAD containing adrenodoxin...
39 KB (4,310 words) - 14:35, 24 September 2024
CYP2E1 (redirect from Cytochrome P450 2E1)
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism...
26 KB (2,965 words) - 14:57, 8 November 2024
Cytochrome P450 aromatic O-demethylase is a bacterial enzyme that catalyzes the demethylation of lignin and various lignols. The net reaction follows the...
8 KB (828 words) - 14:39, 24 January 2024
Lanosterol 14 alpha-demethylase (redirect from Cytochrome P450 14a-demethylase)
cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol. The cytochrome P450 isoenzymes...
10 KB (1,066 words) - 05:53, 15 December 2023
misclassified because they share activity profiles similar to those of cytochrome P450 (CYP450), which is the major contributor to oxidative xenobiotic metabolism...
32 KB (3,764 words) - 21:13, 12 August 2023
phase 1 metabolism of amphetamine analogs is catalyzed by two systems: cytochrome P450 and flavin monooxygenase. Cashman JR, Xiong YN, Xu L, Janowsky...
23 KB (2,453 words) - 23:52, 29 October 2024
Coenzyme Q10 (redirect from List of foods containing Vitamin Q)
CoQ10 may interfere with warfarin's actions by interacting with cytochrome p450 enzymes thereby reducing the INR, a measure of blood clotting. The structure...
50 KB (4,992 words) - 21:34, 23 October 2024
Cimetidine (category Cytochrome P450 inhibitors)
responsible for its hepatotoxicity, is formed from it by the cytochrome P450 system (specifically, CYP1A2, CYP2E1, and CYP3A4). Used in cancer metastasis...
50 KB (5,133 words) - 06:08, 31 October 2024
Dextroamphetamine (redirect from Amphetamine transdermal system)
phase 1 metabolism of amphetamine analogs is catalyzed by two systems: cytochrome P450 and flavin monooxygenase. ... Amphetamine can also undergo aromatic...
63 KB (20,898 words) - 20:42, 9 November 2024
Hydrocodone/paracetamol (category Drugboxes which contain changes to verified fields)
metabolized to norhydrocodone by cytochrome P450 3A4 and to hydromorphone, also biologically active, by cytochrome P450 2D6. For individuals who have a defect...
22 KB (1,834 words) - 22:24, 2 October 2024
Metabolism (redirect from Metabolic system)
humans, these include cytochrome P450 oxidases, UDP-glucuronosyltransferases, and glutathione S-transferases. This system of enzymes acts in three stages...
113 KB (12,407 words) - 11:21, 2 November 2024
Vitamin D (redirect from List of foods containing Vitamin D)
cancer, including melanoma. Vitamin D requires activation by cytochrome P450 (CYP) enzymes to become active and bind to the VDR. Specifically, CYP27A1...
163 KB (17,774 words) - 22:30, 2 November 2024
One notable system involved in metabolic drug interactions is the enzyme system comprising the cytochrome P450 oxidases. Cytochrome P450 is a very large...
29 KB (2,971 words) - 18:21, 3 September 2024
Quercetin (category Articles containing unverified chemical infoboxes)
vitro studies show that quercetin is a strong inhibitor of the cytochrome P450 enzymes CYP3A4 and CYP2C19 and a moderate inhibitor of CYP2D6. Drugs that...
26 KB (2,467 words) - 13:46, 2 November 2024
Roxithromycin (category Drugboxes which contain changes to watched fields)
interactions than erythromycin as it has a lower affinity for cytochrome P450. Roxithromycin is not known to interact with hormonal contraceptives, prednisolone...
8 KB (428 words) - 20:57, 10 October 2024
Dextromethorphan (category Drugboxes which contain changes to verified fields)
including dextromethorphan, through the inhibition of the cytochrome P450 system in the liver, and can lead to excessive accumulation of the drug which...
51 KB (4,618 words) - 10:31, 10 November 2024
Roquefortine C (category Articles containing unverified chemical infoboxes)
Delaforge M (April 2005). "Oxidative metabolism by P450 and function coupling to efflux systems: modulation of mycotoxin toxicity". Food Additives and...
7 KB (566 words) - 20:24, 29 January 2023
Fluconazole (category General cytochrome P450 inhibitors)
glucose-galactose malabsorption Fluconazole is an inhibitor of the human cytochrome P450 system, particularly the isozyme CYP2C19 (CYP3A4 and CYP2C9 to lesser extent)...
31 KB (2,817 words) - 04:18, 27 October 2024