mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene. It has a homotrimeric structure, with three blades curving into a...

Armenian descent. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian...

close homolog PIEZO2 were cloned in 2010, using an siRNA-based screen for mechanosensitive ion channels. PIEZO1 (this gene) and PIEZO2 share 47% identity...

system. Merkel cells express PIEZO2, a mechanosensitive ion channel that responds to mechanical forces. Mice in which Piezo2 is knocked-out specifically...

in the PIEZO2 gene exhibit specific deficits in joint proprioception, as well as vibration and touch discrimination, suggesting that the PIEZO2 channel...

Gordon syndrome is a rare autosomal dominant disorder caused by mutation in PIEZO2. It affects males and females equally. Fewer than 50 cases have been reported...

mechanosensitivity is hypothesised to be linked to the expression of PIEZO1 and PIEZO2 on neurons in the petrosal and nodose ganglia. Baroreceptor action potentials...

Earley T.J., Ranade S., Petrus M.J., Dubin A.E., Patapoutian A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels...

2010. Retrieved 3 January 2010.[dead link] "Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage"...

markers synaptophysin and chromogranin A. Furthermore, the ion channel Piezo2 and transcription factor Atoh1, both specific to Merkel cells, are also...

cell are independently mechanosensitive. The Merkel cell expresses the PIEZO2 mechanosensitive ion channels; mechanical activation of the channel causes...

Nobel Prize laureate known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors William W. Parmley – Former Editor of the Journal of...

activation itself in higher animals (this is now thought to be carried out by PIEZO2 instead). ENaC is present in apical cell membranes of taste receptors where...

for [i.a.] temperature and touch [the discovery/mechanics of TRPV1 and PIEZO2] Nobel Prize in Physics – Syukuro Manabe and Klaus Hasselmann (1/2) "for...

151050 PTDSS1 Lissencephaly 3 611603 TUBA1A Marden–Walker syndrome 248700 PIEZO2 MASA syndrome 303350 L1CAM Microhydranencephaly 605013 NDE1 Mowat–Wilson...

Farshid; Liedtke, Wolfgang B. (2014-11-25). "Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage"...

Q5BN46 12122 PIERCE2 HGNC:44654 H3BRN8 12123 PIEZO1 HGNC:28993 Q92508 12124 PIEZO2 HGNC:26270 Q9H5I5 12125 PIF1 HGNC:26220 Q9H611 12126 PIGA HGNC:8957 P37287...

channels and the recently cloned cation selective PIEZO family (PIEZO1 and PIEZO2). MSCs can be classified based on the type of ion to which they are permeable:...

channel in the analgesic pathway. PLD2 is upstream of Piezo2 and inhibits the channel. Piezo2 is an excitatory channel, ence PLD inhibits an excitatory...

suggests INAVA may interact with the following proteins: DNAJC5G, SLC7A13, PIEZO2, MUC19. Experimental evidence, from a yeast two hybrid screen, suggests...

Torres JM, Bee L, Dickenson AH, Gringhuis M, et al. (2013). "A role for Piezo2 in EPAC1-dependent mechanical allodynia". Nature Communications. 4: 1682...