Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein that in humans is encoded...
13 KB (1,603 words) - 02:15, 10 March 2024
The main inhibitor of tissue plasminogen activator and urokinase is plasminogen activator inhibitor-1 (PAI-1). Plasminogen activator inhibitor-1 is a serine...
9 KB (1,083 words) - 14:08, 27 January 2024
Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that...
23 KB (2,909 words) - 16:49, 26 July 2024
1992). "Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the...
28 KB (3,187 words) - 01:22, 14 May 2024
Urokinase (redirect from Urinary plasminogen activator)
urokinase are the serpins plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2), which inhibit the protease activity irreversibly...
20 KB (2,290 words) - 08:54, 4 May 2024
strong fibrinolytic activity and works by inactivating plasminogen activator inhibitor 1 (PAI-1). Although it should be expected to be digested and inactivated...
6 KB (633 words) - 15:51, 24 July 2024
Coagulation (redirect from Platelet activation)
shrinkage of the clot volume. Plasminogen activators, such as tissue plasminogen activator (t-PA), activate plasminogen into plasmin, which promotes lysis of...
67 KB (6,817 words) - 22:55, 7 August 2024
Protease (redirect from Protease accumulated by inhibitors)
antithrombin (which protects the body from excessive coagulation), plasminogen activator inhibitor-1 (which protects the body from inadequate coagulation by blocking...
26 KB (2,799 words) - 15:02, 30 June 2024
themselves inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2 (PAI-1 and PAI-2). In contrast, plasminogen further stimulates...
9 KB (1,060 words) - 08:01, 31 May 2024
interleukin-6 (IL-6) monocyte chemotactic protein-1 (MCP-1) plasminogen activator inhibitor-1 (PAI-1) retinol binding protein 4 (RBP4) tumor necrosis factor...
4 KB (443 words) - 07:08, 27 April 2024
imaging Plasminogen activator inhibitor-1 (PAI-1), a protein that inhibits fibrinolysis (breakdown of blood clots) Plasminogen activator inhibitor-2 (PAI-2)...
2 KB (336 words) - 08:16, 14 August 2023
Plasminogen activator Pla (EC 3.4.23.48) is an enzyme. This enzyme catalyses the following chemical reaction Converts human Glu-plasminogen to plasmin...
3 KB (400 words) - 15:28, 26 August 2023
complex antibody Livedo vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity and prothrombin G20210A heterozygosity...
25 KB (2,547 words) - 05:54, 8 March 2024
deficiency of alpha-2-antiplasmin (alpha-2-plasmin inhibitor) or plasminogen activator inhibitor type 1 (PAI-1) are very rare. The affected individuals show...
7 KB (825 words) - 02:30, 14 September 2022
to plasminogen activator inhibitor-1 (PAI-1), and stabilizes it. Thus vitronectin serves to regulate proteolysis initiated by plasminogen activation. In...
9 KB (1,057 words) - 10:46, 24 December 2023
Serpin (redirect from Serine protease inhibitor)
"Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene". Blood. 90 (1): 204–208...
137 KB (14,294 words) - 16:56, 26 July 2024
Plasmin (redirect from Plasminogen)
plasminogen activator. Urokinase plasminogen activator receptor (uPAR) is a cofactor for plasminogen activation by urokinase plasminogen activator. The conversion...
15 KB (1,821 words) - 02:15, 10 March 2024
Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic...
26 KB (2,334 words) - 20:11, 26 January 2024
Eerenberg AJ, et al. (December 1993). "Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies...
11 KB (1,096 words) - 14:00, 24 December 2023
Antithrombin (category Serine protease inhibitors)
to that of the physiologically latent conformation of plasminogen activator inhibitor-1 (PAI-1). For this reason the conformation of antithrombin in which...
45 KB (5,339 words) - 16:44, 26 July 2024
TF and plasminogen activator inhibitor-1 (PAI-1), which prevents fibrinolysis. Excess circulating thrombin results from the excess activation of the coagulation...
23 KB (2,460 words) - 16:29, 20 July 2024
and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene". Genes Dev. 12 (19): 3084–95. doi:10.1101/gad.12.19...
11 KB (1,380 words) - 22:15, 24 July 2024
Alpha 2-antiplasmin (redirect from Plasmin inhibitor)
Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is...
11 KB (1,337 words) - 00:12, 20 December 2023
demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like...
4 KB (492 words) - 14:35, 29 September 2023
which are deficient for plasminogen activator inhibitor-1 (PAI-1). PAI-1 inhibits plasminogen activators and thus plasmin activation; therefore it could be...
50 KB (5,450 words) - 01:03, 22 June 2024
SERBP1 (category Genes on human chromosome 1)
Plasminogen activator inhibitor 1 RNA-binding protein (serbp1) is a protein that in humans is encoded by the SERBP1 gene. SERBP1 has been shown to interact...
8 KB (1,034 words) - 20:03, 8 April 2022
is a drug which acts as an inhibitor of the serpin protein plasminogen activator inhibitor-1 (PAI-1). By inhibiting PAI-1, it increases activity of the...
4 KB (265 words) - 08:11, 19 July 2024
Drotrecogin alfa (redirect from Drotrecogin alfa (activated))
profibrinolytic activity by inhibiting plasminogen activator inhibitor-1 (PAI-1).[citation needed] In vitro data also suggest that activated protein C may exert...
15 KB (1,675 words) - 19:31, 20 December 2023
Urokinase receptor (redirect from Urokinase plasminogen activator receptor)
The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 (Cluster of Differentiation 87), is a protein encoded...
10 KB (1,151 words) - 09:59, 3 December 2023
cytokines that promote endothelial dysfunction, and plasminogen activator inhibitor-1, which inhibits the breakdown of clots (fibrinolysis). Often, DVT...
144 KB (14,636 words) - 14:26, 21 June 2024