1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene. SMAD1 belongs to the SMAD, a family of proteins...

receptors, the phosphorylated receptor complex activates SMAD1 and SMAD5. Then, the Smad2/3 or the Smad1/5 complexes form a dimer complex with SMAD4 and become...

which activates the protein. There are five receptor regulated SMADs: SMAD1, SMAD2, SMAD3, SMAD5, and SMAD9 (sometimes referred to as SMAD8). There...

R-SMADS include SMAD2 and SMAD3 from the TGF-β/Activin/Nodal branch, and SMAD1, SMAD5 and SMAD8 from the BMP/GDP branch of TGF-β signaling. In response...

participate in BMPR2 signaling. The SMAD transcription factor family, including SMAD1, SMAD4, and SMAD9 are involved in signaling pathways downstream from BMPR2...

factors that regulate the expression of certain genes. The R-Smads consist of Smad1, Smad2, Smad3, Smad5 and Smad8/9, and are involved in direct signaling from...

is one), which in turn phosphorylate a complex of SMAD proteins (chiefly SMAD1, SMAD5 and SMAD8). These bind to SMAD4 and migrate to the cell nucleus where...

Mariana, et al. (2017). "Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs". Development...

specific TF according to literature or domain structure – No motif [825] SMAD1 ENSG00000170365 SMAD Known motif – In vivo/Misc source [826] DRCAGASAGGSH...

(2002). "Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: Alternative mode for Dlx3 induction in mouse keratinocytes"....

first group of type I receptors (Alk1/2/3/6) bind and activate the R-Smads, Smad1/5/8. The second group of type I reactors (Alk4/5/7) act on the R-Smads,...

associated with pulmonary arterial hypertension. The pulmonary system relies on SMAD1, SMAD5, and SMAD 8 to regulate pulmonary vascular function. Downregulation...

decapentaplegic" named Medea. SMAD4 interacts with R-Smads, such as SMAD2, SMAD3, SMAD1, SMAD5 and SMAD8 (also called SMAD9) to form heterotrimeric complexes. Transcriptional...

homolog of the Drosophila gene "Mothers against decapentaplegic", e.g. SMAD1 a module file format for music on computers Madh Island near Mumbai, India...

and then form a complex with ACVR1. These go on to recruit the R-SMADs SMAD1, SMAD2, SMAD3 or SMAD6. Gain-of-function mutations in the gene ACVR1/ALK2...

as ACVR2A and BMPR2, it binds BMPs thereby activating the intracellular SMAD1/5/8 signalling pathway. In humans this protein is encoded by the RGMA gene...

peripheral neurons including ASCL1, ATF3, CREB1, HIF1α, JUN, KLF6, KLF7, MYC, SMAD1, SMAD2, SMAD3, SOX11, SRF, STAT3, TP53, and XBP1. Several of these can also...

patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1". Development. 124 (16): 3177–84. doi:10.1242/dev.124.16.3177. PMID 9272958...

K, Taga T (April 1999). "Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300". Science. 284 (5413): 479–82. Bibcode:1999Sci....

Q8IY92 15269 SLX4IP HGNC:16225 Q5VYV7 15270 SLX9 HGNC:15811 Q9NSI2 15271 SMAD1 HGNC:6767 Q15797 15272 SMAD2 HGNC:6768 Q15796 15273 SMAD3 HGNC:6769 P84022...

NFATC2, NPAS2, P53, PAX6, PCNA, PROX1, PTMA, PPARA, PPARG, RORA, RELA, SMAD1, SMAD2, SMAD7, SNIP1, SS18, STAT3, STAT6, TAL1, TCF3, TFAP2A, TGS1, TRERF1...

"Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal". Cell. 131 (5): 980–993. doi:10.1016/j.cell.2007.09.027. PMC 2200633...

to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway. Levels of the LRG protein are markedly elevated in acute appendicitis...

RUNX2 has been shown to interact with: AR ER-α C-Fos, C-jun, HDAC3, MYST4, SMAD1 SMAD3, and STUB1. and SMOC1. miR-133 and CyclinD1/CDK4 directly inhibits...

cell viability and the osteogenic differentiation of DFCs via the BMP2/Smad1 feedback loop ). DFCs control the proportional amount of all three periodontal...

includes Smad1 and Smad2/3, were attenuated along with Smad-dependent gene transcription. Another result in this study was that both Smad1/5/8-dependent...

alleles. BMP4 acts through its downstream intercellular transcription factors SMAD1 and SMAD5. During approximately the same time, WNT3 starts to be expressed...

osteoblast differentiation by inducing AMP-activated protein kinase as well as Smad1/5/9. Chrysophanol acts to improve renal interstitial fibrosis by downregulating...

inhibits gliogenesis by binding transcriptional co-activators like CBP/Smad1 or p300/Smad1 preventing the transcription of glialdifferentiation genes. On the...

regeneration-associated genes (RAGs), including well-known RAGs such as Atf3, Bdnf, and Smad1, that regulate the axon growth potential of neurons. Ziller MJ, Müller F...