The human gene SRD5A2 encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of three isozymes of 5α-reductase...
8 KB (1,048 words) - 03:21, 8 November 2023
deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2). The condition is...
39 KB (4,243 words) - 11:47, 2 January 2025
There are three isozymes of 5α-reductase encoded by the genes SRD5A1, SRD5A2, and SRD5A3. 5α-Reductases catalyze the following generalized chemical reaction:...
37 KB (4,017 words) - 02:57, 2 November 2024
(2004). "Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in boys with micropenis". J. Urol. 172 (1): 319–24...
9 KB (961 words) - 13:31, 2 January 2025
(type 1) and SRD5A2 (type 2), with the latter being the most biologically important isoenzyme. There is also third 5α-reductase: SRD5A3. SRD5A2 is most highly...
67 KB (6,840 words) - 00:18, 4 November 2024
androgen synthesis that bypasses testosterone as an intermediate product. SRD5A2 catalyzes the 5α-reduction of 11-ketotestosterone that terminates at 11-ketoandrosterone...
6 KB (541 words) - 22:33, 10 April 2024
SRD5A1 and possibly, SRD5A2 enzymes. While the role of the SRD5A1 enzyme in this reaction is well established, it is unclear whether SRD5A2 is also involved...
11 KB (1,041 words) - 11:22, 1 January 2025
Sevim (2016). "Homozygous Ala65Pro Mutation with V89L Polymorphism in SRD5A2 Deficiency". Journal of Clinical Research in Pediatric Endocrinology. 8...
51 KB (6,333 words) - 16:00, 2 January 2025
into the more potent androgen, 5α-dihydrotestosterone (DHT). The SRD5A1, SRD5A2, and SRD5A3 genes in humans all encode 5α-reductase isozymes. The 3-oxo-5α-steroid...
18 KB (2,005 words) - 10:48, 7 December 2024
adrenal cortex into 21dF or 11OHP4, respectively, 5α-reduction by SRD5A1/SRD5A2, cleavage of a side-chain (C17-C20 bond) from the steroid nucleus by 17...
79 KB (8,735 words) - 07:29, 14 October 2024
in XY newborns may hide a 5α-reductase deficiency: report of three new SRD5A2 gene mutations". International Journal of Andrology. 33 (6): 841–847. doi:10...
82 KB (8,270 words) - 11:15, 2 January 2025
progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma". BMC Cancer. 4: 27. doi:10.1186/1471-2407-4-27...
8 KB (1,053 words) - 03:42, 12 August 2024
K. (2009). "Longer (TA)n Repeat but Not A49T and V89L Polymorphisms in SRD5A2 Gene May Confer Prostate Cancer Risk in South Indian Men". Journal of Andrology...
39 KB (3,816 words) - 16:20, 16 October 2024
Q6ZRS2 15784 SRCIN1 HGNC:29506 Q9C0H9 15785 SRD5A1 HGNC:11284 P18405 15786 SRD5A2 HGNC:11285 P31213 15787 SRD5A3 HGNC:25812 Q9H8P0 15788 SREBF1 HGNC:11289...
242 KB (17 words) - 18:43, 6 October 2024
type IB; 603233; STX16 Pseudovaginal perineoscrotal hypospadias; 264600; SRD5A2 Pseudoxanthoma elasticum; 264800; ABCC6 Pseudoxanthoma elasticum, forme...
234 KB (18,877 words) - 06:16, 6 November 2024