transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein...

phosphorylate (add phosphate groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many...

family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in type II interferon...

proteins to interact with each other come together to form STAT1-STAT1 homodimers. The STAT1-STAT1 homodimers can then enter the cell nucleus. They then initiate...

different mechanisms. P, V, and W contain STAT1 binding domains, and act as interferon antagonists by sequestering STAT1 in the nucleus and cytoplasm. The C...

fight infection, in total there are 9 possible types of this condition. Stat1(CANDF7 mutation on Chromosome 2q32) CHR 2 Chronic mucocutaneous candidiasis...

phosphorylate IFNGR1, thereby forming a paired set of Stat1 docking sites on the ligated receptor. Two Stat1 molecules then associate with the paired docking...

mutation in a Fgf gene, causing a premature and constitutive activation of the Stat1 transcription factor. Chondrocyte cell division is prematurely terminated...

IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription...

the IL-12 signalling pathway. The trait was mapped to mutations in the STAT1 gene, which were associated with lower production of interferon-γ, IL-17...

to proliferate in the body. eVP24 disrupts the signaling pathway of STAT1. The STAT1 protein is phosphorylated by interferons in response to viral infection...

bound to its receptors on the neighbouring cell, the signalling proteins STAT1 and STAT2 are activated and move to the cell's nucleus. This triggers the...

BAG1, CAV3, MED12, MED24, NCOR1, NCOR2, NCOA2 RXRA, RUNX1, RUNX1T1, SNW1, STAT1, and ZBTB16. Click on genes, proteins and metabolites below to link to respective...

Defects in B cells activation in response to TLRs ligands Nuclear defects STAT1 Hypogammaglobulinemia, reduced number of memory and plasma cells NFKB Impaired...

different signaling pathways involved in carcinogenesis responses such as STAT1 activation, gp96-activated macrophages, and activation of NK cells. Therefore...

Butyrate also suppresses colonic inflammation by inhibiting the IFN-γ–STAT1 signaling pathways, which is mediated partially through histone deacetylase...

while greatly upregulating PD-L2. It has been shown by STAT1-deficient knock-out mice that STAT1 is mostly responsible for upregulation of PD-L1 on macrophages...

hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation". Antiviral Research. 184: 104967. doi:10.1016/j.antiviral...

Shoji, K.; Suzuki, H. (2008). "Aqueous extract of Arbutus unedo inhibits STAT1 activation in human breast cancer cell line MDA-MB-231 and human fibroblasts...

affinities of a protein to different DNA sites. STAT1 DNA association: ChIP-seq was used to study STAT1 targets in HeLa S3 cells which are clones of the...

polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells". Journal of Neuroinflammation. 14 (1): 155. doi:10...

cell subset. Th1 cells, which express IFNγ, are generated by IL-27 through STAT1 dimerization and nuclear localization which subsequently leads to the expression...

transcription activators. In response to IFN, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9) and form ISGF-3 (IFN-stimulated...

B cells, and IL-10 CD4 T cells. The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC...

negatively regulates STAT3 and inhibits other STAT proteins like STAT5 and STAT1. STAT5 is important for regulatory T cell (Treg) differentiation and function...

FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ, PIK3R1, PTPN11, PTPN6, STAT1, SOCS1, SOCS6, SRC, and TEC. Cytokine receptor List of genes mutated in...

IL12RB2, IL23R, ISG15, MCTS1, RORC, TBX21, TYK2, CYBB, JAK1, IFNGR1, IFNGR2, STAT1, USP18, IRF1, IRF8, NEMO, SPPL2A). Antiserum Antivenin Cell-mediated immunity...

EIF3F EIF4EBP1, FKBP1A, GPHN, KIAA1303, PRKCD, RHEB, RICTOR, RPS6KB1, STAT1, STAT3, Two-pore channels: TPCN1; TPCN2, and UBQLN1. GRCh38: Ensembl release...

U (July 2008). "Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations". Proceedings of the National Academy...

contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA...