Sorafenib, sold under the brand name Nexavar, is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma)...

partner at Institutional Venture Partners (an original Onyx backer). Sorafenib, co-developed and co-marketed with Bayer and sold under the trade name...

phase 3 randomized, open-label, clinical trial of Pexa-Vec plus sorafenib versus sorafenib is being conducted on patients with advanced hepatocellular carcinoma...

months. The most common side effects of Sorafenib include a hand-foot skin reaction and diarrhea. Sorafenib is thought to work by blocking growth of...

Peginterferon alfa-2b is being studied to treat plexiform neurofibromas. Sorafenib is being studied for treatment of unresectable plexiform neurofibroma...

people with hepatocellular carcinoma who have been previously treated with sorafenib. The approval was based on CELESTIAL (NCT01908426), a randomized (2:1)...

and various receptor tyrosine kinases. It is a deuterated derivative of sorafenib with improved pharmacokinetic properties. Keam SJ, Duggan S (November...

therapy (IL-2, interferon), kinase inhibitors (temsirolimus, sunitinib, sorafenib, pazopanib) and anti-angiogenic therapies (bevacizumab). "Clear cell carcinoma"...

with advanced hepatocellular carcinoma who were previously treated with sorafenib. MetastaticCRC: After the CORRECT trial, two phase 3 trials (CONSIGN,...

conformations of the kinase domain as cancer therapeutic candidates. BAY43-9006 (Sorafenib, Nexavar) is a V600E mutant B-Raf and C-Raf inhibitor approved by the...

molecules that inhibit the tyrosine kinases stimulated by VEGF: sunitinib, sorafenib, axitinib, and pazopanib (some of these therapies target VEGF receptors...

sorafenib to transition to tivozanib following progression disease but not those on the experimental arm using tivozanib to transition to sorafenib....

Other therapeutic options in this setting are pazopanib (Votrient), sorafenib (Nexavar), temsirolimus (Torisel), interleukin-2 (Proleukin), everolimus...

diastolic was reported in the first 24 hours after the first treatment with sorafenib, a VEGF pathway inhibitor.[non-primary source needed] Because these drugs...

Motesanib Nintedanib Pazopanib Radotinib Quizartinib Ripretinib Sunitinib Sorafenib Toceranib Antibodies: Olaratumab Ramucirumab Tovetumab RET (GFL) SCF (c-Kit)...

showed significantly extended progression-free survival when compared to sorafenib. In December 2011, the Oncologic Drugs Advisory Committee (ODAC) voted...

inhibited by sorafenib. Giving sorafenib in combination with rifampicin or inducers of CYP3A4 can decrease plasma concentration of sorafenib. CYP3A4 inhibitors...

metabolic changes associated with depression in metastatic breast cancer, sorafenib and thyroid cancer, pemetrexed-based chemotherapy in lung cancer, atypical...

treatment, with the most common toxicity being diarrhea. Imatinib, sunitinib, sorafenib, and pazopanib have been studied in the treatment of aggressive fibromatosis...

of liver cancer produced sorafenib, a targeted therapy drug that prevents cell proliferation and blood cell growth. Sorafenib obtained FDA approval for...

Midostaurin Nintedanib Odronextamab Pazopanib Pexidartinib Quizartinib Regorafenib Ripretinib Sorafenib Sunitinib Tebentafusp Tepotinib Vandetanib Venetoclax...

Motesanib Nintedanib Pazopanib Radotinib Quizartinib Ripretinib Sunitinib Sorafenib Toceranib Antibodies: Olaratumab Ramucirumab Tovetumab RET (GFL) SCF (c-Kit)...

Motesanib Nintedanib Pazopanib Radotinib Quizartinib Ripretinib Sunitinib Sorafenib Toceranib Antibodies: Olaratumab Ramucirumab Tovetumab RET (GFL) SCF (c-Kit)...

Assay, which is used to detect the FLT3 mutation in patients with AML. Sorafenib has been reported to show significant activity against Flt3-ITD positive...

(OSM) Thymic stromal lymphopoietin (TSLP) Additional cytokine receptor modulators: Emfilermin Lestaurtinib Midostaurin Quizartinib Sorafenib Sunitinib...

Because of this finding, erlotinib has replaced gefitinib in this setting. Sorafenib (Nexavar) Sunitinib (Sutent) Dasatinib (Sprycel) Lapatinib (Tykerb) Nilotinib...

followed by bevacizumab 15 mg/kg IV on the same day, every 3 weeks, or sorafenib orally twice daily. In July 2020, it was approved in the United States...

for clinical use, kinase inhibitors that also inhibit Raf kinases (e.g. Sorafenib) are successful antineoplastic agents against various types of cancer...

Targeted cancer therapies, especially the tyrosine kinase inhibitors sorafenib and sunitinib, have also been associated with a high incidence of acral...

N, Furuichi Y, Imai Y (2013). "Hepatocellular carcinoma treated with sorafenib: Early detection of treatment response and major adverse events by contrast-enhanced...