The TIM barrel (triose-phosphate isomerase), also known as an alpha/beta barrel,: 252  is a conserved protein fold consisting of eight alpha helices (α-helices)...

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Look up Tim, tim, or TIM in Wiktionary, the free dictionary. Tim or TIM may refer to: Timothy (given name) Tim (given name) Timmy Timo Timotheus Tim, Denmark...

parallel to the barrel and the α-helix is in the outside of the barrel but does not contact the α-helices of the other repeats like in TIM barrels. The protein...

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or the immunoglobulin fold) or they can be closed β-barrels (such as the TIM barrel). β-Barrels are often described by their stagger or shear. Some open...

In protein structures, a beta barrel (β barrel) is a beta sheet (β sheet) composed of tandem repeats that twists and coils to form a closed toroidal structure...

— tryptophan synthase family Fold Type III — alanine racemase family (TIM-barrel) Fold Type IV — D-amino acid aminotransferase family Fold Type V — glycogen...

while another suggests that a stable TIM-barrel structure has evolved through convergent evolution. The TIM-barrel in pyruvate kinase is 'discontinuous'...

eight alpha/beta barrels that create an active site holding two divalent magnesium ions. Xylose isomerase enzymes exhibit a TIM barrel fold with the active...

protein subunits of both classes each have an α/β domain folded into a TIM barrel containing the active site. Several subunits are assembled into the complete...

notable structural formations, including a type of β-barrel known as a jelly roll barrel and a TIM barrel. Human β-glucuronidase is homologous to the Escherichia...

families Clans of glycoside hydrolases Hierarchical classification of the TIM-barrel type glycoside hydrolases Bourne, Yves; Henrissat, Bernard (2001). "Glycoside...

These enzymes are involved in purine metabolism. These enzymes adopt a TIM barrel structure. Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips...

αβ-barrel, or a TIM-barrel, and is by far the most commonly observed protein fold. The active site of this enzyme is in the center of the barrel. A glutamic...

site of the enzyme. The catalytic domain of Beta-galactosidases have a TIM barrel core surrounded several other largely beta domains. The sugar binding...

cysteine proteases by disrupting their structure. TIM barrel superfamily Members share a large α8β8 barrel structure. It is one of the most common protein...

triosephosphate isomerase (TIM) barrel, pleckstrin homology (PH) domain, four tandem EF hand domains, and a C2 domain. The TIM barrel contains the active site...

the proteins have from 209 to 241 amino acid residues. The enzyme has a TIM barrel structure. The systematic name of this enzyme class is D-ribulose-5-phosphate...

proteins of diverse function and diverse evolution. For example, the TIM barrel, named for the enzyme triosephosphateisomerase, is a common tertiary structure...

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the N-terminal domain has an alpha-beta fold, the central domain has a TIM barrel fold, and the C-terminal domain has an all alpha helical fold....

consists of two TIM-barrel domains that bind homocysteine and N5-MeTHF individually. The two domains adopt a face-to-face double barrel architecture, which...

antiparallel helical bundle that plugs the C terminus of the N-terminal TIM barrel domain. The communication domain is thought to play an important role...

1-60 and residues 91-358, which fold into a β/α structure of a typical TIM barrel. The loop β4 contains two highly conserved residues Asp183 and Glu184...

immunoglobulin fold. Domain III (residues 76–381 and 416–430) is homologous to a TIM barrel and is a highly conserved domain among glycoside hydrolases. Domain III...

central tunnel observed in most TIM barrel proteins, and pdxJ has three extra alpha helices compared to the classical TIM fold. These three extra helices...

the structure. Each domain I comprises a (β/α)8 - barrel structural fold, also known as a TIM barrel, and contains an active site of the enzyme. Each active...

The flavodoxin fold is a common α/β protein fold, second only to the TIM barrel fold. It has three layers, with two α-helical layers sandwiching a 5-stranded...