Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol)...

agents include taxanes and epothilones, both of which prevent cancer cells from dividing by interfering with tubulin. While taxanes like Paclitaxel and...

(mBC) in patients who have been treated previously with trastuzumab and a taxane (paclitaxel or docetaxel), and who have already been treated for mBC or...

In enzymology, a taxane 10beta-hydroxylase (EC 1.14.13.76) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-yl acetate + NADPH...

In enzymology, a taxane 13alpha-hydroxylase (EC 1.14.13.77) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-ol + NADPH + H+...

paclitaxel or docetaxel. The core carbon skeleton of a normal natural product taxane (e.g., paclitaxel, docetaxel) has a 6-membered A ring, 8-membered B ring...

liver problems. Use during pregnancy may harm the baby. Docetaxel is in the taxane family of medications. It works by disrupting the normal function of microtubules...

and include important compounds such as retinol, phytol or taxadiene. Taxanes are class of diterpenoids featuring a taxadiene core. They are produced...

Taxamairin A is a non-taxane isolate of Taxus yunnanensis. Li SH, Zhan HJ, Yao P, Niu XM, Xiang W, Sun HD (2002). "Non-taxane compounds from the bark...

unresectable, and/or metastatic breast cancer who received prior trastuzumab and taxane therapy for metastatic disease or developed disease recurrence during or...

that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function...

as the plant is a source of the class of poisonous chemicals known as taxanes, which have been a focus for cancer research. T. canadensis is much more...

derivative of a natural taxoid. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.[citation needed] Cabazitaxel was developed...

molecules have generated significant interest after the introduction of the taxanes into clinical oncology and the general use of the vinca alkaloids. Examples...

showed it did not prevent CIPN and appeared to worsen the conditions in taxane therapy. Male infertility: Scientific reviews from 2016 and 2014 showed...

chemotherapeutic properties. Taxoids are usually treated as synonymous with taxanes; for example, a major medical dictionary defines the two terms with the...

permanently in a state of assembly and disassembly. Vinca alkaloids and taxanes are the two main groups of anti-microtubule agents, and although both of...

Gradishar WJ (June 2006). "Albumin-bound paclitaxel: a next-generation taxane". Expert Opinion on Pharmacotherapy. 7 (8): 1041–1053. doi:10.1517/14656566...

Tumors that evolve resistance to docetaxel may receive the second-generation taxane drug cabazitaxel. Some CRPC treatments are used only in men whose tumors...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...

Yunnanxane is a bioactive taxane diterpenoid first isolated from Taxus wallichiana. Yunnanxane was later isolated from cell cultures of Taxus cuspidata...

"Hypothyroidism as a Consequence of Intensity-Modulated Radiotherapy With Concurrent Taxane-Based Chemotherapy for Locally Advanced Head-and-Neck Cancer". International...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...

drugs that can alter microtubule dynamics include: The cancer-fighting taxane class of drugs (paclitaxel (taxol) and docetaxel) block dynamic instability...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...

concentrations, and retains activity in cases where tumor cells are insensitive to taxane type drugs. On October 16, 2007, the U.S. Food and Drug Administration approved...

breast cancer, taxane-containing chemotherapy regimens appear to improve survival and tumour shrinkage and decrease time to progression. Taxanes are associated...

Pavlakis N, Davey R (December 2007). "A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship" (PDF). Cancer...

Tesetaxel is an orally administered taxane being investigated as a chemotherapy agent for various types of cancer, including breast cancer, gastric cancer...