Tofacitinib, sold under the brand Xeljanz among others, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis...
35 KB (3,270 words) - 15:33, 10 October 2024
been explored, including immunomodulatory agents such as imiquimod. Tofacitinib citrate may also have benefits. In June 2014, a 25-year-old man with...
11 KB (1,130 words) - 10:21, 11 October 2024
transcription. The first JAK inhibitor to reach clinical trials was tofacitinib. Tofacitinib is a specific inhibitor of JAK3 (IC50 = 2 nM) thereby blocking...
37 KB (3,296 words) - 02:08, 8 November 2024
colitis, myeloid metaplasia with myelofibrosis and vitiligo. Examples are tofacitinib, baricitinib, upadacitinib and filgotinib. In 2014 researchers discovered...
9 KB (974 words) - 14:46, 22 June 2024
gene expression in immunological cells. Other JAK inhibitors include tofacitinib, which is indicated for the treatment of rheumatoid arthritis, psoriatic...
43 KB (3,613 words) - 18:17, 17 November 2024
current generic equivalent available on the market. The JAK1 inhibitors tofacitinib (Xeljanz) and upadacitinib (Rinvoq) are approved for the use in active...
32 KB (3,440 words) - 01:34, 28 October 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
26 KB (2,676 words) - 02:12, 19 November 2024
The US Food and Drug Administration (FDA) requires a boxed warning for tofacitinib, baricitinib, and upadacitinib to include information about the risks...
46 KB (4,534 words) - 15:25, 4 November 2024
neratinib, eltrombopag, ibrutinib, lenvatinib, palbociclib, regorafenib, tofacitinib, and trelagliptin. BEACON Medicare Limited(BML) is the exclusive global...
5 KB (232 words) - 10:23, 8 March 2024
availability of TNF inhibitors and other agents, such as tocilizumab and tofacitinib. Penicillamine works by reducing numbers of T-lymphocytes, inhibiting...
16 KB (1,390 words) - 07:56, 12 November 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
29 KB (2,520 words) - 06:36, 16 November 2024
combination with either methotrexate or leflunomide. Biologic monotherapy or tofacitinib with methotrexate may improve ACR50, RA remission rates and function...
149 KB (16,153 words) - 04:13, 11 November 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
33 KB (2,958 words) - 00:23, 12 October 2024
vitiligo and other skin diseases. A medication for rheumatoid arthritis, tofacitinib, has been tested for the treatment of vitiligo. In October 1992, a scientific...
42 KB (4,411 words) - 16:07, 13 November 2024
tocofenoxate (INN) tocofersolan (INN) tocofibrate (INN) Today todralazine (INN) tofacitinib (USAN) tofenacin (INN) tofetridine (INN) Tofidence tofimilast (USAN)...
7 KB (373 words) - 02:05, 25 April 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
4 KB (443 words) - 07:08, 27 April 2024
surgery, hospitalization, pregnancy, the use of corticosteroids and tofacitinib, a JAK inhibitor. Osteoporosis may occur related to systemic inflammation...
142 KB (16,206 words) - 01:32, 14 November 2024
Ozanimod L04AE03 Siponimod L04AE04 Ponesimod L04AE05 Etrasimod L04AF01 Tofacitinib L04AF02 Baricitinib L04AF03 Upadacitinib L04AF04 Filgotinib L04AF05 Itacitinib...
3 KB (367 words) - 15:37, 25 January 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
23 KB (2,087 words) - 09:12, 24 August 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
33 KB (3,686 words) - 07:30, 20 May 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
26 KB (2,155 words) - 19:16, 30 October 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
13 KB (1,176 words) - 21:00, 10 July 2024
Kotb A, Christensen R, Mudano AS, et al. (May 2016). "Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or...
24 KB (2,084 words) - 05:31, 21 October 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
25 KB (2,344 words) - 01:12, 1 September 2024
foundation of targeted therapy. Janus kinase inhibitors, e.g. FDA approved tofacitinib ALK inhibitors, e.g. crizotinib Bcl-2 inhibitors (e.g. FDA approved venetoclax...
20 KB (2,234 words) - 01:21, 22 July 2024
Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P...
32 KB (2,851 words) - 23:22, 16 August 2024
with reduced side effects compared to other similar drugs. Delgocitinib Tofacitinib Roda G, Dal Buono A, Argollo M, Danese S (September 2020). "JAK selectivity:...
2 KB (153 words) - 20:24, 22 June 2024
upadacitinib.[medical citation needed] Less selective JAK inhibitors (e.g. tofacitinib and baricitinib) are already being marketed.[medical citation needed]...
24 KB (2,250 words) - 06:06, 16 July 2024
for the treatment of eczema and dermatitis. Delgocitinib Izencitinib Tofacitinib Raghuvanshi R, Bharate SB (January 2022). "Recent Developments in the...
3 KB (246 words) - 20:24, 22 June 2024
received approval from the Food and Drug Administration for Xeljanz, a tofacitinib, for rheumatoid arthritis and ulcerative colitis. The drug had sales...
168 KB (14,575 words) - 20:40, 12 November 2024