U.S. Route 5 (US 5) is a north–south United States Numbered Highway running through the New England states of Connecticut, Massachusetts, and Vermont...

United States Numbered Highway System (often called U.S. Routes or U.S. Highways) is an integrated network of roads and highways numbered within a nationwide...

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International...

U.S. Route 2 or U.S. Highway 2 (US 2) is an east–west United States Numbered Highway spanning 2,571 miles (4,138 km) across the northern continental United...

U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the...

U.S. Route 99 (US 99) was a main north–south United States Numbered Highway on the West Coast of the United States until 1964, running from Calexico,...

U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England...

U.S. Route 30 or U.S. Highway 30 (US 30) is an east–west main route of the United States Numbered Highway System, with the highway traveling across the...

U.S. Route 65 (US 65) is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) was one of the original highways in the United States Numbered Highway System. It was established...

U.S. Route 70 or U.S. Highway 70 (US 70) is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central...

"north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each...

U.S. Route 191 (US 191) is a north–south highway in the Western United States and a spur of parent route U.S. Route 91 that has two segments. The southern...

U.S. Route 73 (US 73) is a north–south United States highway that runs for 113 miles (182 km) from northeast Kansas to southeast Nebraska. The highway's...

three-digit highway, it is still considered part of the double-digit U.S. Highway System. US 412 overlaps with U.S. 43, U.S. 56, US 60, U.S. 62, U.S. 63, U.S. 64...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 101, or U.S. Highway 101 (US 101), is a north–south highway that traverses the states of California, Oregon, and Washington on the West Coast...

U.S. Route 380 (US 380) is an east–west United States highway. The highway's eastern terminus is in Greenville, Texas at an intersection with Interstate...

Wyoming. The highway was not part of the original 1926 U.S. Highway system. The highway was created in the 1930s, absorbing former U.S. Route 530 and...

U.S. Route 275 (US 275) is a north–south United States highway that is a branch of US 75. It originally terminated at US 75 in Council Bluffs, Iowa. The...

U.S. Route 93 (US 93) is a major north–south 1,359-mile (2,187 km) U.S. Numbered Highway in the western United States, that connects U.S. Route 60 (US 60)...

U.S. Route 10 or U.S. Highway 10 (US 10) is an east–west United States Numbered Highway located in the Midwest and Great Lakes regions of the U.S. Despite...

U.S. Route 85 (US 85) is a 1,479-mile-long (2,380 km) north–south United States Highway that travels in the Mountain and Northern Plains states of the...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside of...

U.S. Route 49 (US 49) is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route...

U.S. Route 400 (US 400) is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada...

U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route...

U.S. Route 71 or U.S. Highway 71 (US 71) is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United...

U.S. Route 271 (US 271, US-271) is a north–south United States highway. Never a long highway, it went from bi-state route (Arkansas and Oklahoma) to a...