U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and...

U.S. Route 81 (US-81) is a north–south U.S. highway running through the central United States' Great Plains region, from Fort Worth, Texas to the U.S...

U.S. Highway 81 (US 81) is a U.S. Highway that begins at an interchange with Interstate 35W/US 287 (I-35W/US 287) in northern Fort Worth in Texas. US 81...

U.S. Route 81 (US-81) is a part of the U.S. Highway System that travels from Fort Worth, Texas to the Pembina–Emerson Border Crossing near Pembina, North...

U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route...

U.S. Route 81 has eight special routes. Three are in Texas, one in Oklahoma, two in Kansas, and two in North Dakota. There are officially three business...

to the Interstate era, US 181 traveled into Downtown San Antonio along Presa St. to an intersection with its parent route, US 81, which then ran along...

U.S. Route 177 (US-177) is a spur of U.S. Route 77. It currently runs for 233 miles (375 km) from South Haven, Kansas at US-81 to Madill, Oklahoma at US-70...

U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western...

U.S. Route 11 or U.S. Highway 11 (US 11) is a major north–south United States Numbered Highway extending 1,645 miles (2,647 km) across the eastern U.S...

U.S. Route 460 (US 460) is an auxiliary route of U.S. Route 60. It currently runs for 655 miles (1,054 km) from Norfolk, Virginia, at its parent route...

intersection of Interstate 81 (I-81) / U.S. Route 52 (US 52) in Wytheville. Despite the "1" indicating that it is a major north–south highway, US 21 only travels...

Interstate 81 (I-81) and Virginia State Route 211 (SR 211) in New Market east to US 15 Business, US 29 Business, and US 211 Business in Warrenton. US 211 connects...

U.S. Route 275 (US 275) is a north–south United States highway that is a branch of US 75. It originally terminated at US 75 in Council Bluffs, Iowa. The...

U.S. Route 277 (US 277, US-277) is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route...

U.S. Route 60 is a major east–west United States highway, traveling 2,655 miles (4,273 km) from southwestern Arizona to the Atlantic Ocean coast in Virginia...

U.S. Route 22 (US 22) is a major east–west route and one of the original United States Numbered Highways, founded in 1926. It runs from Cincinnati, Ohio...

U.S. Route 82 (US 82) is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern...

U.S. Route 136 is an east-west U.S. highway that is a spur route of U.S. Route 36. It runs from Edison, Nebraska, at U.S. Route 6 and U.S. Route 34 to...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S...

U.S. Route 377 (US 377) is a 478-mile-long (769 km) north–south United States highway. Originally formed as a short spur to connect Denton, Texas with...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 322 (US 322) is a 494-mile-long (795.0 km), east–west United States Highway, traversing Ohio, Pennsylvania, and New Jersey. The road is a spur...

spur route of I-35 that travels through the western part of Wichita. Its northern terminus is at an interchange with I-135/U.S. Highway 81 (US-81)/K-15/K-96/K-254...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

U.S. Route 58 (US 58) is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S...

U.S. Highway 57 (US 57) is a 98-mile (158 km) north–south intrastate United States highway that follows a nearly east–west route in the southwestern part...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...