WNT4 is a secreted protein that, in humans, is encoded by the WNT4 gene, found on chromosome 1. It promotes female sex development and represses male sex...

WNT4 deficiency is a rare genetic disorder that affects females and it results in the underdevelopment and sometimes absence of the uterus and vagina....

studies have served to rule-out genes as causative factors, but thus far, only WNT4 has been associated with Müllerian agenesis with hyperandrogenism. Reports...

[clarification needed] This disorder is caused by an implication in the WNT4 protein coding gene, which is found on the short arm (p) of chromosome 1...

encoded by the RSPO1 gene, found on chromosome 1. In humans, it interacts with WNT4 in the process of female sex development. Loss of function can cause female...

DAX1, then testes can develop in an XX individual. Mutations in SF1 and WNT4 genes have also been studied in connection with SRY-negative XX male syndrome...

Poulat, F.; Behringer, R. R.; Lovell-Badge, R.; Capel, B. (2006). "Fgf9 and Wnt4 Act as Antagonistic Signals to Regulate Mammalian Sex Determination". PLOS...

and LHX1 are decreased in people with MRKH. Mice with mutant alleles for Wnt4, Wnt5a, Wnt7a and Wnt9b display varying extents of Müllerian duct hypoplasia...

autosomal recessive disorder in XX humans. It is caused by loss of function in WNT4, a protein involved in sex development. The main outcome is female to male...

involved in ovarian development. An assortment of genes and proteins - such as WNT4, RSPO1, FOXL2, and various estrogen receptors - have been shown to prevent...

specific genes being expressed, where multiple pro-ovarian genes (including Wnt4, FoxL2, and Rsp01) and the lack of Sry gene expression are responsible. The...

determining factors. There are a number of factors that are there, like WNT4, like DAX1, whose function is to counterbalance the male pathway. In mammals...

intervention by the SRY gene. However, in the early 2000s, other genes, such as WNT4 and RSPO1, were discovered that perform the opposite function – i.e., genes...

pathway by up-regulating Wnt4 which is an essential step in ovary differentiation. Research has shown that ovaries lacking Rspo1 or Wnt4 will exhibit sex reversal...

Chromosome Gene/cytoband Gene Product Function 1 WNT4/1p36.12 Wingless-type MMTV integration site family member 4 Vital for development of the female reproductive...

association with other serious conditions. These include Fraser syndrome, WNT4 deficiency, and Bardet-Biedl syndrome, Isolated incidents of vaginal anomalies...

There are other variations in which, during embryonic development, the WNT4 gene is activated and/or the SRY gene is damaged leading to birth of an XY...

Poulat F, Behringer RR, Lovell-Badge R, Capel B (June 2006). "Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination". PLOS...

Species Wnt proteins Homo sapiens WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10A, WNT10B, WNT11...

driving the differentiation into male or female structures are SF1, WT1, and WNT4. The other genes have roles in development that are not exclusively sex-related...

MTA3-NuRD complex regulates the expression of Wnt4 in mammary epithelial cells and mice, and controls Wnt4-dependent ductal morphogenesis. In contrast to...

involved in ovarian development. An assortment of genes and proteins - such as WNT4, RSPO1, FOXL2, and various estrogen receptors - have been shown to prevent...

produced from the gonads, the Müllerian will develop thanks to the presence of Wnt4 , while the Wolffian ducts, which are responsible for male reproductive parts...

microbiotic species in the vagina Congenital vaginal defects Imperforate hymen WNT4 deficiency Vaginal adenosis Cloacal exstrophy Vaginal agenesis Vaginal hypoplasia...

signalling pathway is crucial for initiating MET, where specifically the WNT4 protein is required for induction of epithelial renal vesicles and the transition...

critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad". Molecular Endocrinology. 17 (4): 507–519...

specific Wnt family proteins that are expressed are Wnt5a, Wnt5b, Wnt7a and Wnt4. When a muscle becomes injured (thus requiring regeneration) Wnt5a, Wnt5b...

Q93097 18329 WNT3 HGNC:12782 P56703 18330 WNT3A HGNC:15983 P56704 18331 WNT4 HGNC:12783 P56705 18332 WNT5A HGNC:12784 P41221 18333 WNT5B HGNC:16265 Q9H1J7...

feedback loop upregulating SOX9, while simultaneously inactivating the female Wnt4 signaling pathway. In lung development, FGF9 is expressed in the mesothelium...

C-terminal PDZ domain-binding motif. Fz-6 is believed to be the receptor for the WNT4 ligand. Fz-6 has been shown to interact with secreted frizzled-related protein...