A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation...
10 KB (1,179 words) - 18:31, 8 August 2024
Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases...
56 KB (6,475 words) - 07:21, 26 August 2024
another inhibitor to the malfunction enzyme that causes the leukemia. This inhibitor is a highly selective Bcr-Abl tyrosine kinase inhibitor. Sunitinib...
43 KB (5,251 words) - 10:44, 24 June 2024
receptor Tyrphostins Bcr-Abl tyrosine kinase inhibitors Robinson DR, Wu YM, Lin SF (November 2000). "The protein tyrosine kinase family of the human genome"...
28 KB (3,078 words) - 07:46, 3 June 2024
and inhibits BCR-ABL's influence on the cell cycle. Second generation BCR-ABL tyrosine-kinase inhibitors are also under development to inhibit BCR-ABL mutants...
30 KB (3,502 words) - 08:07, 14 August 2024
Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in...
27 KB (2,837 words) - 12:09, 16 October 2024
Imatinib (category Non-receptor tyrosine kinase inhibitors)
treat cancer. Imatinib is a small molecule inhibitor targeting multiple tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and PDGFR-β. Specifically, it...
71 KB (6,702 words) - 05:32, 9 August 2024
Philadelphia chromosome (redirect from Bcr-abl fusion protein)
chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR - ABL tyrosine kinase, CGP 57148". Cell Death and Differentiation. 5 (8): 710–715...
29 KB (3,538 words) - 15:01, 5 December 2023
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling...
28 KB (3,166 words) - 19:57, 8 August 2024
donor, such as ATP, to tyrosine residues in proteins. Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that can transfer...
21 KB (2,716 words) - 15:11, 26 August 2023
Nilotinib (category Non-receptor tyrosine kinase inhibitors)
It is not safe for use during pregnancy. Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer...
20 KB (1,697 words) - 00:44, 27 August 2024
A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that...
23 KB (750 words) - 23:26, 13 August 2024
action as a tyrosine kinase, targeted therapies (the first of which was imatinib) that specifically inhibit the activity of the BCR-ABL protein have...
34 KB (3,877 words) - 01:25, 22 July 2024
Bosutinib (category Non-receptor tyrosine kinase inhibitors)
sold under the brand name Bosulif, is a small molecule BCR-ABL and src tyrosine kinase inhibitor used for the treatment of chronic myelogenous leukemia...
10 KB (633 words) - 12:29, 5 August 2024
Saracatinib (category Non-receptor tyrosine kinase inhibitors)
AstraZeneca. It acts as a dual kinase inhibitor, with selective actions as a Src inhibitor and a Bcr-Abl tyrosine-kinase inhibitor. It was originally under...
7 KB (592 words) - 12:43, 5 August 2024
Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK, along with ZAP70, is...
18 KB (2,083 words) - 06:18, 25 December 2023
(TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several effector molecules. Tyrosine-protein kinase CSK is involved in the following...
8 KB (977 words) - 00:09, 6 October 2021
Dasatinib (category Non-receptor tyrosine kinase inhibitors)
the baby. It is a tyrosine-kinase inhibitor and works by blocking a number of tyrosine kinases such as Bcr-Abl and the Src kinase family. Dasatinib was...
22 KB (1,994 words) - 04:41, 3 January 2024
Radotinib (category Tyrosine kinase inhibitors)
myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such as patients resistant or intolerant to imatinib. Radotinib...
5 KB (293 words) - 13:20, 24 September 2024
LYN (redirect from Lyn (Src family kinase))
receptor (BCR), CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family...
32 KB (3,807 words) - 18:24, 2 October 2024
ALL treatment. Tyrosine-kinase inhibitors (TKIs), such as imatinib, are often incorporated into the treatment plan for people with Bcr-Abl1+ (Ph+) ALL...
78 KB (7,755 words) - 17:38, 17 September 2024
KIT (gene) (redirect from Tyrosine kinase mutation)
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or...
35 KB (4,117 words) - 00:12, 6 August 2024
Axitinib (category Receptor tyrosine kinase inhibitors)
name Inlyta, is a small molecule tyrosine kinase inhibitor developed by Pfizer. It has been shown to significantly inhibit growth of breast cancer in animal...
16 KB (1,194 words) - 23:36, 16 August 2024
Fibroblast growth factor receptor 1 (category Tyrosine kinase receptors)
growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members...
44 KB (5,003 words) - 07:11, 15 October 2024
acid Dihydrofolate reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine...
12 KB (877 words) - 15:36, 25 January 2024
PTK2 (redirect from PTK2 protein tyrosine kinase 2)
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a...
41 KB (4,724 words) - 09:43, 11 December 2023
receptor antagonists Bcr-Abl tyrosine-kinase inhibitors Cannabinoid receptor antagonists CCR5 receptor antagonists Cyclooxygenase 2 inhibitors Dipeptidyl peptidase-4...
44 KB (5,022 words) - 08:47, 12 October 2024
Asciminib (category Non-receptor tyrosine kinase inhibitors)
2018). "Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1". Journal of Medicinal Chemistry. 61 (18): 8120–8135...
17 KB (1,263 words) - 09:31, 30 July 2024
Ponatinib (category Non-receptor tyrosine kinase inhibitors)
was developed by Ariad Pharmaceuticals. It is a multi-targeted tyrosine-kinase inhibitor. Some forms of chronic myeloid leukemia, those that have the T315I...
20 KB (1,623 words) - 12:42, 5 August 2024
imatinib, marketed as Gleevec, which is a kinase inhibitor with exceptional affinity for the oncofusion protein BCR-Abl which is a strong driver of tumorigenesis...
20 KB (2,234 words) - 01:21, 22 July 2024