The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several...

a congenital mutation in the chromosome 13 gene 13q14 (retinoblastoma protein). Retinoblastoma is the most intrusive intraocular cancer among children...

the retinoblastoma tumor suppressor protein. Alfred Knudson, a pediatrician and cancer geneticist, proposed that in order to develop retinoblastoma, two...

initiation. Another dimer present during mid G1 is composed of retinoblastoma protein (pRB) and transcription factor E2F. When pRb is bound to E2F, E2F...

play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells...

Pocket protein family consists of three proteins: RB – Retinoblastoma protein p107 – Retinoblastoma-like protein 1 p130 – Retinoblastoma-like protein 2 They...

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. The protein encoded by this gene is similar...

Cyclin D-CDK4/6 complexes in turn mono-phosphorylates the retinoblastoma susceptibility protein (Rb) to pRb. The un-phosphorylated Rb tumour suppressor...

Retinoblastoma, a childhood cancer of the eyes caused by a mutation in the retinoblastoma protein Retinoblastoma protein, a tumor suppressor protein Rubidium...

in investigations of cell cycle control mechanisms such as the retinoblastoma protein. The World Health Organization's International Agency for Research...

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been shown to interact with: BRCA1...

gene. Additionally, the sonic hedgehog protein has been shown to block activity of the retinoblastoma protein, thereby inducing cell cycle re-entry and...

upregulates the p21 protein, which blocks the formation of the cyclin D/Cdk4 complex, thereby preventing the phosphorylation of retinoblastoma protein (RB), and...

methylated protein and SAH. Known targets of these methyltransferases in humans include RCC-1 (a regulator of nuclear transport proteins) and Retinoblastoma protein...

myeloid). Cyclin D1 is composed of the following protein domains and motifs: retinoblastoma protein (pRb) binding motif; cyclin box domain for cyclin-dependent...

control cetrosome duplication during early S phase. The retinoblastoma tumor suppressor protein (Rb) plays a key regulatory role in several cellular activities...

Nuclear receptor co-repressor 2, P53, RPL11, Retinoblastoma protein, Retinoic acid receptor alpha, SIN3A, SKI protein, STAT3, Serum response factor and Small...

enzymes are responsible for phosphorylating and thus deactivating the retinoblastoma protein, which plays a role in cell cycle progression from the G1 (first...

give an overview of how these proteins modulate host cell processes. The MC007 protein sequesters retinoblastoma protein (pRb) on the mitochondria membrane...

encodes the tumor suppressor retinoblastoma protein, can be detected by cytogenetic analysis in many cases of retinoblastoma. Mutations of the RB1 locus...

cancer cells, and they act by targeting tumor suppressor proteins, such as retinoblastoma protein. The LT antigen possesses a helicase motif needed for virus...

to hyper-phosphorylation and the subsequent destabilization of retinoblastoma protein (Rb). Hypo-phosphorylated Rb, is normally bound to transcription...

In viral status, MCV large tumor antigen (LT antigen) and retinoblastoma protein (RB protein) expression correlates with more favorable prognosis, while...

Guha S, Khavari PA, Alin K, Luban J, et al. (October 1994). "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest"...

Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell...

et al. (June 1999). "Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein". Investigative Ophthalmology & Visual Science. 40 (7): 1343–50...

"A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle". The Journal of Biological...

protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which...

Buchkovich KJ, Marshak DR, Anderson CW, Harlow E (1992). "The retinoblastoma protein is phosphorylated on multiple sites by human cdc2". EMBO J. 10 (13):...

of the retinoblastoma protein. Bioessays. 1999 Nov;21(11):950-8. Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires...