Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins...
53 KB (6,263 words) - 14:38, 30 May 2024
The gene for NDM-1 is one member of a large gene family that encodes beta-lactamase enzymes called carbapenemases. Bacteria that produce carbapenemases...
29 KB (3,207 words) - 18:46, 8 March 2024
Beta-lactamases are a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. In bacterial resistance to beta-lactam antibiotics...
16 KB (1,696 words) - 15:55, 25 July 2024
acids to target different isozymes of beta-lactamases. However, in all cases where infection with β-lactamase-producing bacteria is suspected, the choice...
34 KB (3,708 words) - 13:18, 19 August 2024
production of beta- lactamases. Most beta-lactamases identified in Bacteroides, Prevotella, and Capnocytophaga belong to the Ambler class A. Several beta-lactamases...
16 KB (1,776 words) - 12:47, 23 August 2024
Staphylococcus aureus (beta-lactamase and non-beta-lactamase producing), Staphylococcus epidermidis (beta-lactamase and non-beta-lactamase producing), Staphylococcus...
21 KB (2,031 words) - 07:36, 6 May 2024
J01CR01 Ampicillin and beta-lactamase inhibitor J01CR02 Amoxicillin and beta-lactamase inhibitor J01CR03 Ticarcillin and beta-lactamase inhibitor J01CR04 Sultamicillin...
14 KB (1,151 words) - 15:36, 25 January 2024
pneumonia, especially when Pseudomonas, Acinetobacter, or extended spectrum beta-lactamase producing Enterobacteriaceae are suspected pathogens. Combination therapy...
30 KB (3,489 words) - 16:49, 6 July 2024
Klebsiella possesses beta-lactamase giving it resistance to ampicillin. Many strains have acquired an extended-spectrum beta-lactamase with additional resistance...
42 KB (4,195 words) - 12:11, 8 May 2024
Clavulanic acid (category Beta-lactamase inhibitors)
Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined...
12 KB (1,139 words) - 09:16, 16 January 2024
Acinetobacter baumannii (section Beta-lactamase)
express beta-lactamases known as Acinetobacter-derived cephalosporinases (ADCs), which are class C beta-lactamases. In addition, the beta-lactamase OXA-51...
49 KB (5,450 words) - 14:03, 30 July 2024
inactivated by β-lactamases.[citation needed] Flucloxacillin was developed in the 1960s following an increase in penicillin-resistant (beta-lactamase producing)...
23 KB (2,058 words) - 11:30, 1 July 2024
Gram-negative bacteria and reduces susceptibility to cleavage by Gram-negative beta lactamase enzymes. These properties confer activity against the important hospital...
44 KB (4,767 words) - 05:13, 3 June 2024
antibiotic resistance. Both narrow spectrum beta-lactamases (e.g. penicillinases) and extended spectrum beta-lactamases (ESBL) are common for resistance plasmids...
25 KB (2,787 words) - 06:10, 17 June 2024
susceptible (non-resistant) Gram-positive bacteria. It is active against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise...
11 KB (856 words) - 01:41, 29 March 2024
Penicillin (section β-lactamase inhibitors)
has activity against β-lactamase-producing bacteria due to an acyl side chain that protects the beta-lactam ring from β-lactamase. Penicillin has low protein...
98 KB (10,646 words) - 23:48, 3 August 2024
These beta-lactamase enzymes make many, if not all, of the penicillins and cephalosporins ineffective as therapy. Extended-spectrum beta-lactamase–producing...
54 KB (5,817 words) - 13:54, 7 July 2024
ESCAPPM or ESCHAAPPM is a mnemonic for the organisms with inducible beta-lactamase activity that is chromosomally mediated. E: Enterobacter spp. S: Serratia...
2 KB (173 words) - 05:26, 22 January 2024
"Inhibition of metallo-β-lactamase". 7456274. Alderson R, Barker D, Mitchell JB (2014). "One origin for metallo-beta-lactamase activity, or two? An investigation...
8 KB (1,060 words) - 08:40, 25 April 2024
Sulbactam/durlobactam (category Beta-lactamase inhibitors)
complex. It contains sulbactam, a beta-lactam antibacterial and beta-lactamase inhibitor; and durlobactam, a beta-lactamase inhibitor. Sulbactam/durlobactam...
7 KB (449 words) - 06:17, 10 January 2024
Sulbactam (category Beta-lactamase inhibitors)
a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin. Sulbactam itself contains a beta-lactam ring, and has weak...
6 KB (345 words) - 06:01, 12 August 2023
when a patient has hypersensitivity to penicillins, cephalosporins, beta-lactamase inhibitors or any component of the formulation. The combination is marketed...
9 KB (717 words) - 13:41, 22 August 2024
(2002). "Meropenem stability to beta-lactamase hydrolysis and comparative in vitro activity against several beta-lactamase-producing Gram-negative strains"...
30 KB (2,683 words) - 00:35, 25 May 2024
KPC (Klebsiella pneumoniae carbapenemase) and NDM (New Delhi Metallo-beta-lactamase). KPC and NDM are enzymes that break down carbapenems and make them...
69 KB (8,478 words) - 11:32, 2 May 2024
ceftriaxone is active against Citrobacter spp., Serratia marcescens, and beta-lactamase-producing strains of Haemophilus and Neisseria. However, unlike ceftazidime...
34 KB (3,176 words) - 19:47, 17 August 2024
an orally active beta-lactam antibiotic belonging to the penem group. It is resistant to some forms of extended-spectrum beta-lactamase. It is available...
6 KB (431 words) - 06:38, 3 January 2024
produces and secretes beta-lactamase containing outer-membrane vesicles that can function as an extracellular delivery system of beta-lactam resistance that...
22 KB (2,516 words) - 13:25, 3 July 2024
cover Pseudomonas aeruginosa: Certain cephalosporins, cephalosporin-beta-lactamase-inhibitor combinations, and new siderophore cephalosporins. Ceftazidime...
30 KB (747 words) - 08:06, 6 January 2024
first cephem discovered but while it was highly resistant to several beta-lactamases, as is its derivative cefoxitin, it was almost only effective against...
26 KB (2,646 words) - 22:29, 25 March 2024
although it has been proved to be active against a zinc-dependent beta-lactamase that usually confers antibiotic resistance to certain bacteria, more...
4 KB (192 words) - 16:28, 17 September 2023