An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells...
22 KB (2,564 words) - 17:36, 18 September 2024
Epitope binning is a competitive immunoassay used to characterize and then sort a library of monoclonal antibodies against a target protein. Antibodies...
2 KB (261 words) - 16:41, 26 April 2024
In immunology, cryptic self epitopes are a source of autoimmunity. Self epitopes, which are found in high concentration on the surface of antigen-presenting...
1 KB (156 words) - 20:40, 2 July 2023
In immunology, epitope mapping is the process of experimentally identifying the binding site, or epitope, of an antibody on its target antigen (usually...
23 KB (2,661 words) - 04:37, 28 April 2024
In immunology, a linear epitope (also sequential epitope) is an epitope—a binding site on an antigen—that is recognized by antibodies by its linear sequence...
4 KB (408 words) - 08:07, 4 January 2023
In immunology, a conformational epitope is a sequence of sub-units (usually amino acids) composing an antigen that come in direct contact with a receptor...
3 KB (291 words) - 23:24, 26 November 2022
constitutes an epitope. Most antigens have the potential to be bound by multiple antibodies, each of which is specific to one of the antigen's epitopes. Using...
20 KB (2,435 words) - 03:32, 7 October 2024
the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually...
48 KB (4,964 words) - 23:05, 30 September 2024
Autoimmunity (redirect from Epitope spreading)
self-tolerance. Epitope spreading or epitope drift – when the immune reaction changes from targeting the primary epitope to also targeting other epitopes. In contrast...
50 KB (5,851 words) - 16:28, 29 July 2024
specific chemical constitution of each antibody. The antigenic determinant or epitope is recognized by the paratope of the antibody, situated at the variable...
19 KB (2,268 words) - 19:15, 23 November 2023
antibody recognizes on an antigen is called an epitope. Several antibodies can recognize the same epitope but differ in their binding affinity. The antibody...
21 KB (2,054 words) - 16:47, 21 April 2024
Immunogenicity (section T cell epitopes)
T cell epitope immunogenicity is the binding strength of T cell epitopes to major histocompatibility complexes (MHC or HLA) molecules. Epitopes with higher...
16 KB (1,820 words) - 12:25, 3 September 2024
antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell. In the course of normal immune response...
49 KB (5,613 words) - 10:01, 27 March 2024
expression vectors and in the production of recombinant proteins. Like other epitope tags, HA-tag is small and generally does not alter the traits of proteins...
5 KB (493 words) - 16:09, 9 August 2024
Molecular mimicry (section Epitope spreading)
these "peptide mimic" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is...
28 KB (4,099 words) - 05:30, 10 June 2024
challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope". Clin Rev Allergy Immunol (Review). 38 (2–3): 298–301. doi:10.1007/s12016-009-8160-z...
135 KB (15,557 words) - 01:34, 18 October 2024
allows it to bind to only one epitope with high affinity and as a result, each B cell can only respond to one epitope. The paratopes on B-cell receptors...
4 KB (457 words) - 23:44, 30 June 2023
reactive epitopes to the basement membranes and activate the complement cascade, leading to the death of tagged cells. A specific antibody and epitope binding...
14 KB (1,428 words) - 23:54, 3 March 2024
production of the chemical components (antibodies/immunoglobulins, toxin, epitopes of proteins like CD4, antitoxins, cytokines/chemokines, antigens) of the...
2 KB (218 words) - 18:27, 5 June 2022
FLAG-tag, or FLAG octapeptide, or FLAG epitope, is a peptide protein tag that can be added to a protein using recombinant DNA technology, having the sequence...
7 KB (846 words) - 22:41, 10 August 2024
antibody contains a paratope that specifically binds to one particular epitope on an antigen, allowing the two molecules to bind together with precision...
119 KB (13,400 words) - 17:29, 29 August 2024
displays a small peptide (a molecular fraction of a protein) called an epitope. The presented self-antigens prevent an organism's immune system from targeting...
58 KB (6,785 words) - 20:25, 21 September 2024
Western blot (section Epitope mapping)
antibody's binding sites (epitopes) on the target protein is referred to as "epitope mapping." Finding the binding epitope of an antibody is essential...
66 KB (8,077 words) - 10:16, 9 July 2024
protect from subsequent infections. These memory B cells respond to specific epitopes on the surface of viral proteins to produce antigen-specific antibodies...
12 KB (1,251 words) - 00:30, 25 December 2023
myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection...
2 KB (296 words) - 22:15, 4 April 2024
as "molecular mimicry" occurs when an infectious organism that shares epitopes from its host's afflicted tissue triggers an immune response in the host...
46 KB (5,008 words) - 12:09, 1 October 2024
less non-neutralising epitopes than recombinant monomeric gp120, which act to suppress the immune response to target epitopes. The RNA genome consists...
123 KB (14,115 words) - 13:33, 14 October 2024
unique in that they target conserved epitopes of the virus, meaning the virus may mutate, but the targeted epitopes will still exist. In contrast, non-bNAbs...
8 KB (870 words) - 11:42, 22 August 2024
Bander, N. H.; Lewis, J. S.; Grimm, J. (2011). "Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PET". The Journal...
73 KB (8,763 words) - 14:26, 28 August 2024
divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes presented on its envelope proteins, and into eight major genotypes (A–H)...
86 KB (9,464 words) - 09:28, 11 October 2024