Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins...
53 KB (6,267 words) - 03:15, 28 September 2024
development of the class of enzyme inhibitors called beta-lactamase inhibitors. Although β-lactamase inhibitors have little antibiotic activity of their own...
16 KB (1,696 words) - 15:55, 25 July 2024
resistance to β-lactam antibiotics by synthesizing a β-lactamase, an enzyme that attacks the β-lactam ring. To overcome this resistance, β-lactam antibiotics...
34 KB (3,710 words) - 22:48, 26 September 2024
gene. Later, the journal editor apologized for allowing the name. NDM-1 β-lactamase was also found in a K. pneumoniae isolate from Croatia, and the patient...
29 KB (3,212 words) - 19:54, 11 September 2024
Penicillin (section β-lactamase inhibitors)
or tazobactam, β-lactamase inhibitors, alongside penicillin gives penicillin activity against β-lactamase-producing bacteria. β-Lactamase inhibitors irreversibly...
98 KB (10,637 words) - 21:20, 30 September 2024
Cefixime Cefotaxime Cefpodoxime Ceftazidime Ceftriaxone Cefdinir (With β-lactamase stability and enhanced activity against Gram-positive bacteria and Pseudomonas...
4 KB (175 words) - 02:53, 1 June 2024
ability to make a cell wall. It is resistant to breakdown by many kinds of β-lactamase enzymes, produced by bacteria. Meropenem was patented in 1983. It was...
33 KB (2,958 words) - 19:13, 3 October 2024
β-lactamases, a class of enzymes that break open the β-lactam ring. More than 1,800 different β-lactamase enzymes have been documented in various species of...
11 KB (1,182 words) - 19:18, 26 September 2024
supplementary β-lactam-insensitive PBP. Compared to other β-lactam antibiotics (such as penicillins), they are less susceptible to β-lactamases. Currently...
37 KB (2,502 words) - 04:47, 10 August 2024
a combination consisting of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. It is specifically used for otitis...
23 KB (2,063 words) - 17:51, 2 October 2024
Staphylococcus aureus (beta-lactamase and non-beta-lactamase producing), Staphylococcus epidermidis (beta-lactamase and non-beta-lactamase producing), Staphylococcus...
21 KB (2,031 words) - 08:16, 2 October 2024
Ceftazidime/avibactam (category Beta-lactamase inhibitors)
composed of ceftazidime, a cephalosporin antibiotic, and avibactam, a β-lactamase inhibitor. It is used to treat complicated intra-abdominal infections...
12 KB (988 words) - 10:56, 28 March 2024
Avibactam (category Beta-lactamase inhibitors)
Avibactam is a non-β-lactam β-lactamase inhibitor developed by Actavis (now Teva) jointly with AstraZeneca. A new drug application for avibactam in combination...
8 KB (618 words) - 21:51, 22 April 2024
AmpC-type β-lactamase enzyme, which breaks down penicillins, cephalosporins, and carbapenems; PER-1: encodes a PER-1 type extended-spectrum β-lactamase enzyme...
92 KB (10,021 words) - 09:56, 22 September 2024
Clavulanic acid (category Beta-lactamase inhibitors)
Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined...
23 KB (2,120 words) - 06:12, 28 September 2024
enzymes, as well as the enzyme VIM (Verona Integron-Mediated Metallo-β-lactamase) have also been reported in Pseudomonas. Carbapenem-resistant Enterobacteriaceae...
69 KB (8,479 words) - 08:22, 2 October 2024
Sulbactam (category Beta-lactamase inhibitors)
Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria...
6 KB (345 words) - 06:01, 12 August 2023
amino-benzylpenicillins and ureidopencillins work synergistically with β-lactamase inhibitors. Concurrent use or unregulated dosages of piperacillin results...
44 KB (4,767 words) - 05:13, 3 June 2024
Zhanel GG (2013). "Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella...
30 KB (3,490 words) - 06:18, 9 September 2024
urinary tract infections. It contains cefoperazone, a β-lactam antibiotic, and sulbactam, a β-lactamase inhibitor, which helps prevent bacteria from breaking...
3 KB (113 words) - 20:22, 24 April 2024
combination antibiotic consisting of ticarcillin, a β-lactam antibiotic, and clavulanic acid, a β-lactamase inhibitor. This combination results in an antibiotic...
2 KB (58 words) - 00:46, 26 October 2023
carbapenem/ β-lactamase inhibitor combination (cell wall synthesis inhibitor). FDA approved on 16 July 2019. Meropenem/vaborbactam: carbapenem/ β-lactamase inhibitor...
155 KB (14,566 words) - 19:16, 3 October 2024
The metallo-β-lactamase (MBL) superfamily constitutes a group of proteins found in all domains of life that share a characteristic αββα fold with the...
8 KB (1,060 words) - 16:54, 9 September 2024
inactivated by β-lactamases.[citation needed] Flucloxacillin was developed in the 1960s following an increase in penicillin-resistant (beta-lactamase producing)...
24 KB (2,105 words) - 06:45, 2 October 2024
brand name Emblaveo, is a combination of aztreonam, a β-lactam antibiotic, and avibactam, a β-Lactamase inhibitor, developed by AbbVie and Pfizer for aerobic...
7 KB (483 words) - 05:07, 13 June 2024
Ceftolozane/tazobactam (category Beta-lactamase inhibitors)
otherwise be resistant to ceftolozane. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, which protects ceftolozane from degradation. It...
23 KB (2,206 words) - 05:30, 15 September 2024
Tazobactam (category Beta-lactamase inhibitors)
Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly...
3 KB (144 words) - 21:30, 14 August 2023
Vaborbactam (category Beta-lactamase inhibitors)
Vaborbactam (INN) is a non-β-lactam β-lactamase inhibitor discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. While not effective...
9 KB (669 words) - 08:04, 11 October 2023
Compared to other penicillins that face antimicrobial resistance due to β-lactamase, it is less active, can be administered only parenterally, and has a...
8 KB (698 words) - 21:50, 18 September 2024
combination medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam. The combination has activity against many Gram-positive...
11 KB (965 words) - 14:55, 8 September 2024