• Thumbnail for ARF1
    factor 1 is a protein that in humans is encoded by the ARF1 gene. ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family...
    11 KB (1,380 words) - 05:00, 10 March 2024
  • Thumbnail for ADP ribosylation factor
    GTP but poorly or not at all to the GDP nucleotide. Structural studies of Arf1 and Arf6 have revealed that although these proteins feature the switch 1...
    8 KB (916 words) - 15:25, 28 July 2024
  • Thumbnail for COPI
    form symmetric trimers ("triads"). The curved triad structure positions the Arf1 molecules and cargo binding sites proximal to the membrane. The β′- and α-COP...
    11 KB (1,337 words) - 08:31, 15 January 2024
  • Thumbnail for Muscarinic acetylcholine receptor M3
    necessary for the pre-coupling. It has also been shown to interact with Arf6 and ARF1. Muscarinic acetylcholine receptor GRCh38: Ensembl release 89: ENSG00000133019...
    16 KB (1,761 words) - 18:13, 7 June 2024
  • Golgi membrane, it must interact with a small GTPase called ARF1 (ADP ribosylation factor). ARF1 that is bound to GDP interacts with the golgi complex membrane...
    11 KB (1,270 words) - 23:20, 5 January 2024
  • downregulate response to epinephrine AGPAT1 acyl 3 phosphoglycerol acyl transferase ARF1 ARF3 ARF4 ARF5 ARL2 RAS Superfamily CSF1 Colony stimulating factor not highly...
    48 KB (4,612 words) - 23:41, 12 December 2023
  • scission of the plasma membrane (PM) independent of dynamin, dependence on Arf1 activity, enrichment in GPI-anchored proteins, increased susceptibility to...
    2 KB (266 words) - 18:18, 12 May 2024
  • Thumbnail for Indole-3-acetic acid
    PMC 341922. PMID 14742873. Ulmasov, T; Hagen, G; Guilfoyle, TJ (1997). "ARF1, a transcription factor that binds to auxin response elements". Science....
    26 KB (2,766 words) - 00:37, 15 May 2024
  • Thumbnail for ARFGAP3
    to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation...
    5 KB (641 words) - 03:09, 1 December 2023
  • α-l-arabinofuranosidase called Arf1, which accounts for almost all the arabinofuranosidase activity in the cells. Arf1 is a trimer or tetramer of between...
    4 KB (402 words) - 08:35, 18 May 2022
  • +2-nt movement of the toeprint of the pre-termination complex. The archaeal aRF1–EF1α–GTP complex is similar. The triggering mechanism is similar to that...
    14 KB (1,728 words) - 17:55, 10 July 2024
  • Thumbnail for Ras superfamily
    cellular adhesion RAP1A; RAP1B; RAP2A; RAP2B; RAP2C Arf vesicular transport ARF1; ARF3; ARF4; ARF5; ARF6; ARL1; ARL2; ARL3; ARL4; ARL5; ARL5C; ARL6; ARL7;...
    6 KB (291 words) - 12:53, 5 November 2021
  • originally known as 'KIAA1110', under which name it was found to act as a GEF for Arf1 but not Arf6. It is related to the other Arf-GEF protein IQSEC1. "www.genenames...
    2 KB (238 words) - 04:06, 10 March 2024
  • Thumbnail for Brefeldin A
    Jackson, Catherine L. (2005-03-01). "Dynamics of GBF1, a Brefeldin A-Sensitive Arf1 Exchange Factor at the Golgi". Molecular Biology of the Cell. 16 (3): 1213–1222...
    13 KB (1,289 words) - 09:08, 24 June 2024
  • is shown here. Exomer binds to 2 molecules of ADP-ribosylation factor 1 (Arf1) as shown in this figure. A hinge region of exomer is thought to be important...
    3 KB (290 words) - 20:23, 24 September 2023
  • Thumbnail for ARF3
    family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members...
    11 KB (1,336 words) - 05:11, 24 December 2023
  • HGNC:649 P48444 915 AREG HGNC:651 P15514 916 AREL1 HGNC:20363 O15033 917 ARF1 HGNC:652 P84077 918 ARF3 HGNC:654 P61204 919 ARF4 HGNC:655 P18085 920 ARF5...
    277 KB (17 words) - 23:17, 27 April 2024
  • Thumbnail for Cryogenic electron tomography
    John A G (2017-06-16). "9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments". eLife. 6. doi:10...
    18 KB (1,939 words) - 18:20, 19 April 2024
  • Jiangsha; Yin, Weiqin; Liu, Dayong; Chen, WanJun; Hou, Steven X. (2020-01-10). "Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces...
    23 KB (2,213 words) - 18:17, 23 May 2024
  • Thumbnail for WAVE regulatory complex
    (via the CYFIP1 component of the complex) and Arf small GTPases (such as ARF1, ARF5, and ARF6 ) or the similar protein ARL1, which causes dissociation...
    4 KB (481 words) - 19:51, 23 September 2021
  • Thumbnail for ARFGAP1
    which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of...
    9 KB (1,074 words) - 18:21, 24 January 2024
  • Thumbnail for CYTH2
    sorting and membrane trafficking. CYTH2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. CYTH2 protein is 83% homologous to CYTH1. Two transcript...
    9 KB (1,129 words) - 00:39, 28 March 2024
  • Thumbnail for Arfaptin
    molecular biology, the arfaptin domain is a protein domain which interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature...
    2 KB (172 words) - 16:36, 18 May 2024
  • Thumbnail for HERC1
    The protein encoded by this gene stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein is thought to be involved in membrane transport...
    15 KB (1,525 words) - 07:36, 3 June 2024
  • Thumbnail for CYTH4
    and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are...
    5 KB (619 words) - 03:29, 3 December 2023
  • Thumbnail for Rho gtpase activating protein 21
    Chavrier P (2005). "Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics". Nat. Cell Biol. 7 (4): 353–64...
    5 KB (710 words) - 08:58, 18 August 2023
  • Thumbnail for Anne Spang
    for the uptake of cargo into transport vesicles and that the small GTPase Arf1 and COPI components play a role in mRNA transport and mRNA metabolism. Her...
    7 KB (506 words) - 08:41, 19 September 2023
  • Thumbnail for CYTH3
    ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. GRCh38: Ensembl release 89: ENSG00000008256 – Ensembl, May 2017 GRCm38:...
    8 KB (728 words) - 14:08, 13 October 2022
  • Thumbnail for Mitochondrial fission
    mitochondria-ER contact sites is from the Golgi apparatus. Golgi contain ARF1 proteins localized on their membranes, which are capable of recruiting kinases...
    12 KB (1,678 words) - 07:50, 9 February 2023
  • Thumbnail for ARF5
    family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members...
    8 KB (1,027 words) - 14:16, 27 March 2022