biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino...

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allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters...

enzyme's active site. The remaining majority of the enzyme structure serves to maintain the precise orientation and dynamics of the active site. In some...

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make glucose-6-phosphate. Active site residues of hexokinase allow for stabilization of the glucose molecule in the active site and spur the onset of an...

facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult...

tissues of the body but are at the highest concentration in the liver. The active site of the aldehyde dehydrogenase enzyme is largely conserved throughout...

Mg2+ in the active site of the enzyme involves addition of an "activating" carbon dioxide molecule (CO2) to a lysine in the active site (forming a carbamate)...

repeating α-β subunits, each coupled pair of subunits has an active site, for a total of 12 active sites. It plays an essential function for survival, neutralizing...

the natural substrate ornithine from accessing the active site (Figure 1). Within the active site of ODC, eflornithine undergoes decarboxylation with...

IDH has two active sites. Each active site binds a NAD+/NADP+ molecule and a divalent metal ion (Mg2+,Mn2+). In general, each active site has a conserved...

dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified...

substrate. This is accomplished by blocking the binding site of the substrate – the active site – by some means. The Vmax indicates the maximum velocity...

ranpirnase has two extra active-site residues: Lys9 and an N-terminal pyroglutamate residue.  These additional active sites are created within the endoplasmic...

requirement for L-DOPA as cofactor. The two copper atoms within the active site of tyrosinase enzymes interact with dioxygen to form a highly reactive...

into one of several families based on their active site mechanism. Enzymes that use a metal in the active site are called "metallo-carboxypeptidases" (EC...

newer class of medication, directly inhibit thrombin by binding to its active site. Recombinant thrombin is available as a powder for reconstitution into...

bound in the active site of Caspase 3 in the crystal structure of the complex solved in 2010. The chloromethyl group reacts with the active site cysteine...

heterogeneous catalyst has active sites, which are the atoms or crystal faces where the substrate actually binds. Active sites are atoms but are often described...

while within the active site (e.g. hydrogen bonding or van der Waals forces). Specific and favorable bonding occurs within the active site until the substrate...

has two zinc atoms per subunit. One is the active site, which is involved in catalysis. In the active site, the ligands are Cys-46, Cys-174, His-67, and...

attack the C-2 cation which will leave behind a fructose molecule. The active-site carboxylate anion will take action to help keep the unequal balance of...

motifs which may covalently bind to the acetylcholinesterase enzyme's active site in several places, perhaps explaining the rapid denaturing of the enzyme...

(not shown here) in the active site. The amino acids are shown as wires, and the TPP is in ball and stick form. The active site also aids in the transfer...

acetyl-CoA. Pyruvate decarboxylase occurs as a dimer of dimers with two active sites shared between the monomers of each dimer. The enzyme contains a beta-alpha-beta...

site contains a water molecule or a dioxygen molecule. By contrast the protein myoglobin, found in muscle cells, has only one such unit. The active site...

enzyme acts upon to form the desired product. The substrate binds to the active site of the enzyme to produce an enzyme-substrate complex ES, and is transformed...

hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change...

other loops, are part of the major subdomain that surround the active site. The active site is situated in the N-terminal half of the sequence, which includes...