• Thumbnail for Alternative splicing
    Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single...
    62 KB (7,809 words) - 17:56, 21 May 2024
  • Thumbnail for RNA splicing
    of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur...
    38 KB (4,641 words) - 21:25, 2 September 2024
  • Thumbnail for Primary transcript
    expression. Alternative splicing can be affected by various factors, including mutations such as chromosomal translocation. In prokaryotes, splicing is done...
    21 KB (2,624 words) - 06:00, 3 September 2024
  • Thumbnail for Protein isoform
    However, such transcripts are also produced by splicing errors in a process called "noisy splicing," and are also potentially translated into protein...
    17 KB (2,013 words) - 01:16, 4 January 2024
  • Thumbnail for Serine/arginine-rich splicing factor 1
    Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a...
    21 KB (2,574 words) - 16:59, 7 August 2024
  • Thumbnail for RNA-Seq
    multiple alternative splicing modes: exon skipping (most common splicing mode in humans and higher eukaryotes), mutually exclusive exons, alternative donor...
    103 KB (11,098 words) - 04:11, 29 July 2024
  • structure plots of alternative splicing events from .bam, .gtf, and .vcf files. SpliceR An R package for classification of alternative splicing and prediction...
    164 KB (20,376 words) - 14:18, 16 July 2024
  • Thumbnail for Spinal muscular atrophy
    due to a variation in a single nucleotide (840.C→T) – undergoes alternative splicing at the junction of intron 6 to exon 8, with only 10–20% of SMN2 transcripts...
    89 KB (9,953 words) - 10:33, 25 May 2024
  • Thumbnail for Circular RNA
    examples of alternative splicing is in the Drosophila DSCAM gene, which can give rise to approximately 30 thousand distinct alternatively spliced isoforms...
    55 KB (6,557 words) - 21:55, 24 August 2024
  • Thumbnail for Minigene
    abundance of alternative splicing, which occurs in most human genes, and the specificity in which splicing is carried out in vivo. Splicing is distinctly...
    21 KB (2,427 words) - 08:41, 10 March 2024
  • Thumbnail for SR protein
    SR protein (section Splicing)
    and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA...
    27 KB (3,445 words) - 17:16, 7 August 2024
  • Thumbnail for Alberto Kornblihtt
    is an Argentine molecular biologist who specializes in alternative ribonucleic acid splicing. During his postdoctoral training with Francisco Baralle...
    20 KB (2,229 words) - 18:14, 6 July 2024
  • Intron (category RNA splicing)
    relevant, alternative splicing and processing noise due to splicing errors. One of the central issues in the field of alternative splicing is working out the...
    47 KB (5,839 words) - 23:00, 11 July 2024
  • still remains an important challenge. As a consequence, the role of alternative splicing in molecular biology remains largely elusive. Third generation sequencing...
    33 KB (3,988 words) - 15:39, 3 April 2024
  • mRNA. Alternative splicing is a mechanism by which different proteins can be produced from a single gene by means of using alternative splicing sites...
    47 KB (5,684 words) - 02:09, 17 August 2024
  • Thumbnail for Spliceosome
    Spliceosome (category RNA splicing)
    can still be transcribed and spliced, but their splicing is less efficient compared to those closer to speckles. RNA splicing is a biochemical reaction,...
    22 KB (2,807 words) - 05:41, 3 September 2024
  • Thumbnail for Tropomyosin
    3-9. Alternative splicing can occur at exon 6, with the mutually exclusive choice of exon 6a or 6b. At the c-terminus, the transcript is spliced again...
    51 KB (6,192 words) - 22:52, 17 August 2024
  • Thumbnail for Neuroligin
    alternative splicing, and certain splice variants of neuroligins and neurexins are more selective for one another. Specific pairing of splice variants also...
    22 KB (2,569 words) - 08:15, 13 July 2024
  • Thumbnail for DNA ligase 3
    encodes several distinct DNA ligase species by alternative translation initiation and alternative splicing mechanisms that are described below. Eukaryotic...
    30 KB (3,749 words) - 18:26, 16 August 2024
  • Alternative Splicing Annotation Project (ASAP) in computational biology was a database for alternative splicing data maintained by the University of California...
    2 KB (151 words) - 22:12, 6 February 2022
  • Thumbnail for Exon
    Exon (category RNA splicing)
    RNA splicing. The term exon refers to both the DNA sequence within a gene and to the corresponding sequence in RNA transcripts. In RNA splicing, introns...
    13 KB (1,517 words) - 23:39, 2 April 2024
  • Thumbnail for Sex-lethal
    female-specific alternative splicing of the transformer (tra) pre-mRNA by binding to the tra uridine-rich polypyrimidine tract at the non-sex-specific 3' splice site...
    4 KB (459 words) - 17:48, 11 September 2022
  • Thumbnail for Immunoglobulin D
    diverse with amplifications of Cδ exons. Different splice variants exist due to alternative splicing. In humans and primates, IgD has three Cδ domains...
    17 KB (2,096 words) - 15:53, 6 April 2024
  • exclusion during splicing. These sites are referred to as exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs), intronic splicing enhancers (ISEs)...
    39 KB (4,540 words) - 18:39, 20 July 2024
  • Thumbnail for Cell nucleus
    be spliced in multiple ways to produce different mature mRNAs that encode different protein sequences. This process is known as alternative splicing, and...
    87 KB (9,882 words) - 23:43, 24 August 2024
  • Thumbnail for U11 spliceosomal RNA
    U11 spliceosomal RNA (category RNA splicing)
    RNA in the minor spliceosome protein complex, which activates the alternative splicing mechanism. The minor spliceosome is associated with similar protein...
    7 KB (722 words) - 14:49, 8 June 2022
  • to a sequence could impact splicing, this process may result in changing the identity of introns and exons; alternatively, the sequence may retain its...
    17 KB (2,076 words) - 16:50, 9 June 2024
  • SpliceInfo is a database for the four major alternative-splicing modes (exon skipping, 5'-alternative splicing, 3'-alternative splicing and intron retention)...
    2 KB (99 words) - 15:59, 22 August 2024
  • Thumbnail for RBFOX1
    The primary function is regulation of alternative splicing of associated genes. Several alternatively spliced transcript variants have been found for...
    31 KB (3,549 words) - 19:17, 19 April 2024
  • alternative splicing compared to genes that code a single isoform. This is because alternatively spliced mRNAs are enriched in METTL3 binding sites. Splicing is...
    61 KB (7,732 words) - 20:34, 13 May 2024