• Thumbnail for Aminoacyl tRNA synthetase
    aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase, is an enzyme that attaches the appropriate amino acid onto its corresponding tRNA....
    30 KB (3,606 words) - 00:10, 30 November 2024
  • Thumbnail for Aminoacyl-tRNA
    Aminoacyl-tRNA (also aa-tRNA or charged tRNA) is tRNA to which its cognate amino acid is chemically bonded (charged). The aa-tRNA, along with particular...
    13 KB (1,630 words) - 22:05, 10 May 2024
  • The aminoacyl-tRNA synthetases catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These...
    5 KB (585 words) - 15:20, 1 October 2024
  • Thumbnail for Transfer RNA
    covalent attachment to the tRNA 3' end is catalysed by enzymes called aminoacyl tRNA synthetases. During protein synthesis, tRNAs with attached amino acids...
    67 KB (8,010 words) - 00:05, 30 November 2024
  • Aminoacyl-tRNA synthetases, class II is a family of proteins. These proteins catalyse the attachment of an amino acid to its cognate transfer RNA molecule...
    4 KB (472 words) - 15:19, 1 October 2024
  • enzyme aminoacyl tRNA synthetase catalyzes the binding of adenosine triphosphate (ATP) to a corresponding amino acid, forming a reactive aminoacyl adenylate...
    12 KB (1,608 words) - 10:31, 6 August 2024
  • Thumbnail for Cloverleaf model of tRNA
    and such reactions are often catalyzed by a specific enzymes, aminoacyl tRNA synthetase. For example, if the amino acid that attach to the end is phenylalanine...
    3 KB (296 words) - 21:22, 11 August 2024
  • Thumbnail for Wobble base pair
    seen on aminoacyl tRNA synthetase and the genomes of E. coli tRNA at the External links, Information on Aminoacyl tRNA Synthetases and Genomic tRNA Database...
    13 KB (1,455 words) - 13:19, 5 October 2024
  • Thumbnail for Expanded genetic code
    tRNA and aminoacyl tRNA synthetase are required, these are called the orthogonal set. The orthogonal set must not crosstalk with the endogenous tRNA and...
    79 KB (9,132 words) - 16:16, 17 November 2024
  • Thumbnail for Antisynthetase syndrome
    radiologic features, clinical criteria, and identification of aminoacyl tRNA synthetase antibodies. Immunosuppressive medications such as mycophenolate...
    57 KB (5,502 words) - 15:28, 3 October 2024
  • Thumbnail for Glutamine—tRNA ligase
    cognate tRNA. This enzyme participates in glutamate metabolism and aminoacyl-trna biosynthesis. The human gene for glutaminyl-tRNA synthetase is QARS...
    8 KB (775 words) - 02:36, 16 September 2024
  • aminoacyl tRNA synthetases, enzymes that catalyze the esterification of specific amino acids or their precursors to their corresponding cognate tRNAs...
    22 KB (2,169 words) - 18:47, 5 December 2024
  • Thumbnail for RARS (gene)
    Arginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the RARS gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by...
    9 KB (1,090 words) - 05:04, 13 August 2023
  • Thumbnail for Genetic code
    creating a unique codon (recoding) and a corresponding transfer-RNA:aminoacyl – tRNA-synthetase pair to encode it with diverse physicochemical and biological...
    73 KB (8,046 words) - 18:12, 31 December 2024
  • carbon-oxygen bonds in tRNA and related compounds. More specifically, it belongs to the family of the aminoacyl-tRNA synthetases. These latter enzymes...
    29 KB (3,787 words) - 23:22, 27 March 2024
  • Thumbnail for Translation (biology)
    where mRNA codons are matched through complementary base pairing to specific tRNA anticodons. Aminoacyl-tRNA synthetases that mispair tRNAs with the...
    35 KB (4,027 words) - 10:30, 24 December 2024
  • Thumbnail for Glycine—tRNA ligase
    in glycine, serine and threonine metabolism and aminoacyl-trna biosynthesis. Glycyl-tRNA synthetase has been shown to interact with EEF1D. Mutant forms...
    16 KB (1,940 words) - 22:48, 2 December 2023
  • Thumbnail for WARS (gene)
    Tryptophanyl-tRNA synthetase, cytoplasmic is an aminoacyl-tRNA synthetase enzyme that attaches the amino acid tryptophan to its cognate tRNA. In humans...
    9 KB (1,042 words) - 01:52, 4 March 2023
  • Thumbnail for Leucyl-tRNA synthetase
    member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in...
    9 KB (963 words) - 08:54, 30 January 2024
  • Thumbnail for ATyr Pharma
    2005, aTyr was founded by Paul Schimmel, and Xiang-Lei Yang, two aminoacyl tRNA synthetase scientists at The Scripps Research Institute. In 2009, Bruce Beutler...
    7 KB (784 words) - 20:22, 16 October 2024
  • Thumbnail for Pyrrolysine
    transfer RNA (tRNA) with a CUA anticodon, and the pylS gene, which encodes a class II aminoacyl-tRNA synthetase that charges the pylT-derived tRNA with pyrrolysine...
    21 KB (2,273 words) - 23:26, 10 November 2024
  • is catalyzed by aminoacyl-tRNA synthetase, and requires a molecule of ATP. The amino acid bound to the tRNA is called an aminoacyl-tRNA, and is considered...
    5 KB (566 words) - 18:25, 9 November 2024
  • Thumbnail for Charcot–Marie–Tooth disease
    glycyl-tRNA synthetase (GlyRS). Glycyl-tRNA synthetase is a class II aminoacyl-tRNA synthetase and acts as the catalyst for the synthesis of glycyl-tRNA by...
    42 KB (4,626 words) - 15:43, 7 December 2024
  • Thumbnail for Protein
    transfer RNA molecule, which carries the amino acid corresponding to the codon it recognizes. The enzyme aminoacyl tRNA synthetase "charges" the tRNA molecules...
    103 KB (10,813 words) - 10:10, 30 December 2024
  • Thumbnail for SCYE1
    Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 is a protein that in humans is encoded by the AIMP1 gene. The protein encoded...
    9 KB (1,143 words) - 01:45, 24 December 2023
  • Thumbnail for AARS1
    Alanyl—tRNA synthetase 1 (AARS1) is an enzyme that is encoded by the AARS1 gene in humans and is a member of the aminoacyl-tRNA synthetases (ARSs) family...
    4 KB (496 words) - 03:36, 9 December 2024
  • Thumbnail for Multisynthetase complex auxiliary component p38
    Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene. The JTV1 gene is located...
    8 KB (945 words) - 19:47, 3 March 2023
  • Thumbnail for FARSB
    This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta...
    6 KB (748 words) - 21:03, 3 March 2023
  • Thumbnail for MARS (gene)
    Methionyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the MARS gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs...
    6 KB (731 words) - 04:11, 14 October 2022
  • Thumbnail for D arm
    D arm (category RNA)
    it acts as a recognition site for aminoacyl-tRNA synthetase, an enzyme involved in the aminoacylation of the tRNA molecule. The D stem is also believed...
    2 KB (206 words) - 15:36, 16 April 2024