BC-007, whose international nonproprietary name is Rovunaptabin, is an oligonucleotide aptamer, a synthetic DNA compound designed to bind other chemicals...

various immune-modulating drugs, and the experimental aptamer compound BC-007 (Rovunaptabin). In 2021, the US National Institutes of Health started funding...

writing, over 5,000 years ago, with the earliest records going back to 3,200 BC. Prehistory covers the time from the Paleolithic (Old Stone Age) to the beginning...

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operating as BC Ferries (BCF), is a former provincial Crown corporation, now operating as an independently managed, publicly owned Canadian company. BC Ferries...

The 11th millennium BC spanned the years 11,000 BC to 10,001 BC (c. 13 ka to c. 12 ka or 12,950 BP to 11,951 BP). This millennium is during the ending...

Bronze Age was a historical period lasting from approximately 3300 to 1200 BC. It was characterized by the use of bronze, the use of writing in some areas...

Gaius Julius Caesar Augustus (born Gaius Octavius; 23 September 63 BC – 19 August AD 14), also known as Octavian (Latin: Octavianus), was the founder of...

activated caspase oligomerizer) and long COVID experimental treatment drug BC 007, and to construct a knowledge ark in space, ideally located at least in...

diagnostics. The aptamer TBA (also known as G15D, HTQ, HD1, ARC183, GS522, BC-007, or Rovunaptabin) is a 15-mer single-stranded DNA with the sequence 5'-GGTTGGTGTGGTTGG-3'...

age in the Holocene epoch. Starting around 2200 BC, it most likely lasted the entire 22nd century BC. It has been hypothesised to have caused the collapse...

cattle) 9500 BC – 9000 BC: Oldest known surviving building – Göbekli Tepe, in Turkey 9000 BC – 6000 BC: Domestication of rice in China 9000 BC: Mudbricks...

from c. 5,000 BC. The transition from Copper Age to Bronze Age in Europe occurred between the late 5th and the late 3rd millennium BC. In the Ancient...

49 (4): 482–98. Bibcode:2005JHumE..49..482L. doi:10.1016/j.jhevol.2005.05.007. PMID 16085279. Archived from the original (PDF) on 11 September 2008. Wrangham...

characteristic of elite architecture of the Neopalatial period (c. 1750-1470 BC). They are hypothesized to have been used either as shrines, baths, or as...

north, Thrace to the east and Thessaly to the south. Before the 4th century BC, Macedonia was a small kingdom outside of the area dominated by the great...

Cambridgeshire County Council, 1 December 2012, p. 17. "Placeholder for BC 007 2" and "Leases of tenement in Chain Lane (now St Edwards Passage), in parish...

accounts say he was born as Li Er in the state of Chu in the 6th century BC during China's Spring and Autumn period, served as the royal archivist for...

1900 BC, as the culmination of longer-term social and architectural trends. These initial palaces were destroyed by earthquakes around 1700 BC but were...

2500 BC in modern-day Ghana, the Nok culture from 1500 BC in modern-day Nigeria, the Daima culture around Lake Chad from 550 BC, Djenné-Djenno from 250 BC...

edible grasses is from around 21,000 BC with the Ohalo II people on the shores of the Sea of Galilee. By around 9500 BC, the eight Neolithic founder crops –...

Chinese Zhou dynasty; his reign has been reconstructed to be 827/25 – 782 BC. He worked to restore royal authority after the Gonghe Regency. He fought...

Carthage in 146 BC, a new city of the same name (Latin Carthāgō) was built on the same land by the Romans in the period from 49 to 44 BC. By the 3rd century...

Dordrecht: Springer Netherlands, pp. 1–8, doi:10.1007/978-94-007-6644-0_93-1, ISBN 978-94-007-6644-0 Thomas R.; Ellison R.A.; Goodenough K.M.; Roberts N...

the 2nd millennium BC and the use of iron tools and weapons began to displace copper alloys – in some regions, only around 1200 BC. That event is considered...

several regions, from c. 8000 BC. Thousands of years later, it was the first metal to be smelted from sulfide ores, c. 5000 BC; the first metal to be cast...

independent kingdom from the 4th century BC. Its capital Nicomedia was rebuilt on the site of ancient Astacus in 264 BC by Nicomedes I of Bithynia. Bithynia...

Bond for both the Wii game GoldenEye 007, an enhanced remake of the 1997 game for the Nintendo 64, and James Bond 007: Blood Stone. In addition to Casino...

c. 40,000 BC. The oldest gold artifacts in the world are from Bulgaria and are dating back to the 5th millennium BC (4,600 BC to 4,200 BC), such as those...

temperatures that occurred approximately 8,200 years before the present, or c. 6,200 BC, and which lasted for the next two to four centuries. It defines the start...